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Found 17 Enz. Inhib. hit(s) with all data for entry = 9749
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  150nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Dog)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50:  210nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Dog)
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  590nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  730nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.50E+3nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >1.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Pfizer

US Patent
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent