Compile Data Set for Download or QSAR
Report error Found 219 Enz. Inhib. hit(s) with all data for entry = 11193
TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598601BDBM598601(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598664BDBM598664(US11613531, Example 342 | Ethyl 2-(3,8-diazabicycl...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598596BDBM598596(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598584BDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598630BDBM598630(US11613531, Example 301 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598602BDBM598602(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598581BDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50: 0.900nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598603BDBM598603(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598647BDBM598647(US11613531, Example 319 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 1.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598604BDBM598604(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598655BDBM598655(US11613531, Example 332 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598584BDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598562BDBM598562(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598666BDBM598666(US11613531, Example 344 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598652BDBM598652(US11613531, Example 329 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598631BDBM598631(US11613531, Example 302 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 2.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598606BDBM598606(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3,8-diazabicyclo[...)
Affinity DataIC50: 2.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598636BDBM598636(US11613531, Example 307 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 2.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598581BDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50: 2.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598517BDBM598517(US11613531, Example 228 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 3nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598577BDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50: 3.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598659BDBM598659(US11613531, Example 336 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 3.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598579BDBM598579(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluorop...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598597BDBM598597(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598639BDBM598639(US11613531, Example 310 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 3.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598517BDBM598517(US11613531, Example 228 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 4nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598586BDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50: 4.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598594BDBM598594(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-chloro...)
Affinity DataIC50: 4.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598586BDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598570BDBM598570(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598569BDBM598569(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-6-methylp...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598665BDBM598665(US11613531, Example 343 | 4-((1H-indazol-5-yl)amin...)
Affinity DataIC50: 5.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598663BDBM598663(US11613531, Example 341 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 5.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598577BDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598654BDBM598654(US11613531, Example 331 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598571BDBM598571(N-(2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorop...)
Affinity DataIC50: 6nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598598BDBM598598(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 6.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598648BDBM598648(US11613531, Example 321 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 8nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598649BDBM598649(US11613531, Example 320 | 6-((1H-indazol-5-yl)amin...)
Affinity DataIC50: 8.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598616BDBM598616(N-(6-methyl-2-(3-(piperidin-3-yl)indolin-1-yl)pyri...)
Affinity DataIC50: 9.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598593BDBM598593(N-(2-(3,7-diazabicyclo[4.2.0]octan-3-yl)-6-methylp...)
Affinity DataIC50: 9.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598592BDBM598592(N-(2-(3,6-diazabicyclo[3.2.0]heptan-3-yl)-6-methyl...)
Affinity DataIC50: 11nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598653BDBM598653(US11613531, Example 330 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 11nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598588BDBM598588(N-(2-((1R,6S)-3,7-diazabicyclo[4.2.0]octan-3-yl)py...)
Affinity DataIC50: 12nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598570BDBM598570(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...)
Affinity DataIC50: 12nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598642BDBM598642(US11613531, Example 313 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 14nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598567BDBM598567(N-(6-methyl-2-(2-methyl-1,4-diazepan-1-yl)pyrimidi...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598609BDBM598609(N-(2-(1,4-diazepan-1-yl)pyrimidin-4-yl)-1H-indazol...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598637BDBM598637(US11613531, Example 308 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598617BDBM598617(8-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-8-aza...)
Affinity DataIC50: 15.8nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

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