Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50193974
Substrate
n/a
Meas. Tech.
ChEMBL_424261 (CHEMBL908413)
IC50
9±n/a nM
Citation
Nie, H; Widdowson, KL; Palovich, MR; Fu, W; Elliott, JD; Bryan, DL; Burman, M; Schmidt, DB; Foley, JJ; Sarau, HM; Busch-Petersen, J N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors. Bioorg Med Chem Lett 16:5513-6 (2006) [PubMed] Article
More Info.:
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Human
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
Inhibitor
Name:
BDBM50193974
Synonyms:
6-chloro-3-({(cyanoimino)[(2-fluorophenyl)amino]methyl}amino)-2-hydroxy-N,N-dimethylbenzenesulfonamide | CHEMBL220797
Type:
Small organic molecule
Emp. Form.:
C16H15ClFN5O3S
Mol. Mass.:
411.838
SMILES:
CN(C)S(=O)(=O)c1c(Cl)ccc(N=C(NC#N)Nc2ccccc2F)c1O |w:12.11|