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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50395274
Substrate
n/a
Meas. Tech.
ChEMBL_860361 (CHEMBL2166144)
IC50
5000±n/a nM
Citation
 Kosugi, T; Mitchell, DR; Fujino, A; Imai, M; Kambe, M; Kobayashi, S; Makino, H; Matsueda, Y; Oue, Y; Komatsu, K; Imaizumi, K; Sakai, Y; Sugiura, S; Takenouchi, O; Unoki, G; Yamakoshi, Y; Cunliffe, V; Frearson, J; Gordon, R; Harris, CJ; Kalloo-Hosein, H; Le, J; Patel, G; Simpson, DJ; Sherborne, B; Thomas, PS; Suzuki, N; Takimoto-Kamimura, M; Kataoka, K Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem 55:6700-15 (2012) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAPK2_MOUSE | Mapkapk2 | Rps6kc1
Type:
PROTEIN
Mol. Mass.:
44061.05
Organism:
Mouse
Description:
ChEMBL_860361
Residue:
386
Sequence:
MLSGSPGQTPPAPFPSPPPPAPAQPPPPFPQFHVKSGLQIRKNAITDDYKVTSQVLGLGINGKVLRIFDKRTQQKFALKMLQDCPKARREVELHWRASQCPHIVHIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARAVEDAALAH
  
Inhibitor
Name:
BDBM50395274
Synonyms:
CHEMBL1235213
Type:
Small organic molecule
Emp. Form.:
C20H26N6O
Mol. Mass.:
366.46
SMILES:
CCOc1ccc(Nc2c(C)c(N[C@H]3CCCNC3)nc3ccnn23)cc1 |r|
Structure:
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