Reaction Details
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Target
Tyrosine-protein kinase JAK3
Ligand
BDBM325506
Substrate
n/a
Meas. Tech.
JAK3 Inhibition Assay
IC50
5500±n/a nM
Citation
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More Info.:
Target
Name:
Tyrosine-protein kinase JAK3
Synonyms:
JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase
Type:
Protein
Mol. Mass.:
125111.08
Organism:
Homo sapiens (Human)
Description:
P52333
Residue:
1124
Sequence:
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Inhibitor
Name:
BDBM325506
Synonyms:
(1s,3s)-3-(4-(4-(1-(pentan- 3-yl)-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyrazin- 6-yl)-1H-pyrazol-1- yl)cyclobutanecarboxamide | US10189845, Example 168 | US10730880, Example 168 | US11028093, Example 168
Type:
Small organic molecule
Emp. Form.:
C22H26N8O
Mol. Mass.:
418.4948
SMILES:
CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(N)=O |r,wU:26.32,(.75,4.49,;-.33,3.4,;-1.82,3.8,;-2.22,5.29,;-1.13,6.38,;-2.91,2.71,;-2.43,1.25,;-3.68,.34,;-4.93,1.25,;-4.45,2.71,;-3.68,-1.2,;-2.35,-1.97,;-2.35,-3.51,;-3.68,-4.28,;-5.01,-3.51,;-6.48,-3.98,;-7.38,-2.74,;-6.48,-1.49,;-5.01,-1.97,;-1.01,-4.28,;-1.01,-5.82,;.45,-6.29,;1.36,-5.05,;.45,-3.8,;2.9,-5.05,;3.99,-6.13,;5.07,-5.05,;3.99,-3.96,;6.61,-5.05,;7.38,-6.38,;7.38,-3.71,)|