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Target
Transporter
Ligand
BDBM50198233
Substrate
n/a
Meas. Tech.
ChEMBL_453325 (CHEMBL901477)
Ki
15.4±n/a nM
Citation
 Tamagnan, GD; Brenner, E; Alagille, D; Staley, JK; Haile, C; Koren, A; Early, M; Baldwin, RM; Tarazi, FI; Baldessarini, RJ; Jarkas, N; Goodman, MM; Seibyl, JP Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett 17:533-7 (2007) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50198233
Synonyms:
2-((3-iodophenyl)(2-methoxyphenoxy)methyl)morpholine | CHEMBL247687
Type:
Small organic molecule
Emp. Form.:
C18H20INO3
Mol. Mass.:
425.2608
SMILES:
COc1ccccc1OC(C1CNCCO1)c1cccc(I)c1 |w:10.11,9.9|
Structure:
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