Compile Data Set for Download or QSAR
Report error Found 415 for UniProtKB: D3DT47
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235149(CHEMBL4066780)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235153(CHEBI:67985 | CHEMBL510111)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240379(cid_640180 | (1E,4E)-1,5-Diphenyl-penta-1,4-dien-3...)
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235152(CHEBI:4747 | CHEMBL230128)
Affinity DataIC50: 0.0540nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235142(CHEMBL4070749)
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.0780nMAssay Description:Binding affinity for factor VIIa/TFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235147(Vitalboside A)
Affinity DataIC50: 0.0950nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189445(US9174974, Example 31)
Affinity DataKi:  0.160nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189445(US9174974, Example 31)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human TF-factor 7a (366 to 11 residues) using factor 10 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192767(CHEMBL3984725)
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50234590(CHEMBL4092579)
Affinity DataIC50: 0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346613(Oleanonic Acid | CHEMBL470029)
Affinity DataIC50: 0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)
Affinity DataIC50: 0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189441(US9174974, Example 26)
Affinity DataKi:  0.230nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50205841(CHEMBL3898956)
Affinity DataKi:  0.240nMAssay Description:Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 mins at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240380(2,6-Bis-(benzylidene)-cyclohexanone | 2,6-Bis-[1-p...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50191346(CHEMBL3978562)
Affinity DataKi:  0.280nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235150(CHEBI:67947 | CHEMBL1910843)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  0.430nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192771(CHEMBL3898371)
Affinity DataKi:  0.550nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189429(US9174974, Example 14)
Affinity DataKi:  0.570nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189427(US9174974, Example 12)
Affinity DataKi:  0.610nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235151(CHEMBL4064877)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50098596(CHEMBL3594313)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant TF/F7a complex using S2288 as substrate preincubated for 15 mins followed by protein addition measured for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192766(CHEMBL3967204)
Affinity DataKi:  0.720nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235148(CHEMBL4062123)
Affinity DataIC50: 0.801nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50068224((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 4,4'-di...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50191351(CHEMBL3909009)
Affinity DataKi:  1nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50181921(2-[5-(5-carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to factor7a/TF complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50189939(5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydrox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235154(CHEMBL4080417)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50440849(CHEMBL2431588)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50172757(CHEMBL3808801)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50172786(CHEMBL3809909)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50326044((2S,5S,8R,11S,14S,17S,20S,23S,26R,29S,32S,35S,38S,...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to tissue factor/factor 7aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50098595(CHEMBL3594314)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human Tissue factor/factor 7aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50098595(CHEMBL3594314)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant TF/F7a complex using S2288 as substrate preincubated for 15 mins followed by protein addition measured for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50201268(CHEMBL3919296)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192769(CHEMBL3976650)
Affinity DataKi:  2nMAssay Description:Inhibition of human TF-factor 7a (366 to 11 residues) using factor 10 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50181916([5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-fluo...)
Affinity DataKi:  2nMAssay Description:Binding affinity to factor7a/TF complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50180400(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to F7a/TF complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50191344(CHEMBL3951940)
Affinity DataKi:  2.20nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189416(US9174974, Example 1)
Affinity DataKi:  2.5nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-o...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50189938(2-{5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-3'-[3...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50440822(CHEMBL2431602)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human recombinant soluble tissue factor-factor 7a using H-D-Ile-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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