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TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50137279(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50086884(N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50272470((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50072583((2R,3S)-2,N*1*-Dihydroxy-N*4*-[(S)-1-(1H-indole-3-...)
Affinity DataIC50: 0.260nMAssay Description:In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50: 0.300nMAssay Description:Activity against Matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant pro-MMP1 by spectrofluorimeterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.400nMAssay Description:Activity against Matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082537((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-thi...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082543((S)-4-(4-bromo-2-methylphenylsulfonyl)-N-hydroxy-2...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50290085((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human collagenase (MMP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50069218((2R,3R)-2,N*1*-Dihydroxy-3-isobutyl-N*4*-[(S)-2-(4...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity was evaluated against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082541((S)-4-(4-bromophenylsulfonyl)-N-hydroxy-2,2-dimeth...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataIC50: 0.780nMAssay Description:In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50272468((8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydrox...)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50064340((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-met...)
Affinity DataKi:  0.870nMAssay Description:Inhibition of MMP-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082991((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.880nMAssay Description:Inhibitory activity against MMP-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50109629((4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataKi:  0.970nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50076991((2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-...)
Affinity DataKi: <1nMAssay Description:Inhibition of MMP-1 (human fibroblast collagenase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50076993(CHEMBL542068 | CHEMBL88220 | (2S,11S,12R)-12-Isobu...)
Affinity DataKi: <1nMAssay Description:Inhibition of MMP-1 (human fibroblast collagenase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  1nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082550((S)-4-(4-Methoxy-benzenesulfonyl)-6-methoxymethoxy...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50216802((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50286335((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-(3-...)
Affinity DataKi:  1nMAssay Description:Evaluated for inhibitory activity against Human fibroblast collagenase (HFC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50622040(CHEMBL5394834)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50622041(CHEMBL4859817)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50622039(CHEMBL5400739)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50102750(CHEMBL3359091)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50622045(CHEMBL5412452)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50286344(5-[(S)-2-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pe...)
Affinity DataKi:  1nMAssay Description:Evaluated for inhibitory activity against Human fibroblast collagenase (HFC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50076991((2S,11S,12R)-7-Benzenesulfonyl-12-isobutyl-13-oxo-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50622047(CHEMBL5400294)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant MMP-1 incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50102630(11-Isobutyl-3-methyl-2,10-dioxo-1-oxa-3,9-diaza-cy...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
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