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TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50247011(CHEMBL4080419)
Affinity DataKi:  0.0110nMAssay Description:Competitive inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate at pH 8 by stopped flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50247011(CHEMBL4080419)
Affinity DataKi:  0.0110nMAssay Description:Competitive inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate at pH 8 by stopped flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50349922(CHEMBL1814730)
Affinity DataIC50: 0.0212nMAssay Description:Inhibition of BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 0.0267nMAssay Description:Inhibition of BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM9027(3-(1H-indol-3-yl)-N-(3-{methyl[3-(1,2,3,4-tetrahyd...)
Affinity DataIC50: 0.0300nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50587056(CHEMBL5080685)
Affinity DataIC50: 0.0352nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50349923(CHEMBL1814731)
Affinity DataIC50: 0.0354nMAssay Description:Inhibition of BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599186(CHEMBL5201089)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380553(CHEMBL2019034)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50349921(CHEMBL1814729)
Affinity DataIC50: 0.0449nMAssay Description:Inhibition of BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50005193(CHEMBL3099496)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human butyrylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599186(CHEMBL5201089)
Affinity DataKd:  0.0640nMAssay Description:Binding affinity to human BChE assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50525979(CHEMBL4444855)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599167(CHEMBL5195228)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380541(CHEMBL2019032)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599186(CHEMBL5201089)
Affinity DataKi:  0.0940nMAssay Description:Inhibition of human BChE assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380542(CHEMBL2019037)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM9023(N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)ami...)
Affinity DataIC50: 0.100nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380552(CHEMBL2019035)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380551(CHEMBL2019038)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599173(CHEMBL5200785)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599172(CHEMBL5181960)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50234795(CHEMBL4089082)
Affinity DataKi:  0.131nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM13549(N-[4-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 0.139nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM13550(3-(3,4,5-Trimethoxyphenyl)-N-(6-oxo-6-(2-(1,2,3,4-...)
Affinity DataIC50: 0.141nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50525990(CHEMBL4476861)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50380537(CHEMBL2019030)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50303940(2-(Benzylaminocarbonyloxy-)5-O-Salicyloyl-1,4:3,6-...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of BuChE in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataKi:  0.163nMAssay Description:Competitive inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate at pH 8 by stopped flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50532207(CHEMBL4464964)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of recombinant human BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50587059(CHEMBL5092094)
Affinity DataIC50: 0.177nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50604405(CHEMBL5186889)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to human recombinant BChE in enzyme-inhibitor complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50604405(CHEMBL5186889)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to human recombinant BChE in enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599191(CHEMBL5184728)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM13548(N-[3-(N'-1,2,3,4-tetrahydroacridin-9-ylhydrazineca...)
Affinity DataIC50: 0.226nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM132084(US8841453, 15)
Affinity DataIC50: 0.240nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM132080(US8841453, 11)
Affinity DataIC50: 0.25nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM132071(US8841453, 1)
Affinity DataIC50: 0.25nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50464942(CHEMBL4293015)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant human serum BuChE using butyrylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599188(CHEMBL5184944)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50525991(CHEMBL4461027)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50599164(CHEMBL5201951)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide or butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50587057(CHEMBL5078555)
Affinity DataIC50: 0.265nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50189316(CHEMBL3827288)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50271323(N-{4-[(1,2,3, 4-Tetrahydroacridin-9-yl)amino]butyl...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM132083(US8841453, 14)
Affinity DataIC50: 0.280nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50189320(CHEMBL3827610)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM13543(3,4,5-trimethoxy-N-[7-(N'-1,2,3,4-tetrahydroacridi...)
Affinity DataIC50: 0.293nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changed at 412 nm and was monitored with spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM10693(CHEMBL189957 | 3-{[methyl({7-[(9-oxo-9H-xanthen-3-...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50613754(CHEMBL5282182)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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