Compile Data Set for Download or QSAR
Report error Found 539 for UniProtKB: P25024
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50503347(CHEMBL4442431)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CXCR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50169045((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50169045((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...)
Affinity DataIC50: 1nMAssay Description:Displacement of 125I-IL-8 from CXCR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetC-X-C chemokine receptor type 1/2(Human)
Domp£

Curated by ChEMBL
LigandPNGBDBM50475205(CHEMBL190899)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211458((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)propy...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50200878((R)-3-(2-(1-(furan-2-yl)propylamino)-3,4-dioxocycl...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to human CXCR1 assessed as dissociation constant incubated for 6 to 24 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50200880(2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran...)
Affinity DataIC50: 3.90nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248336(3-(2-((1S,2S)-2-fluoro-1-(4-methylfuran-2-yl)propy...)
Affinity DataKi:  5nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1/2(Human)
Domp£

Curated by ChEMBL
LigandPNGBDBM50169045((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248400((S)-3-(2-(2,2-difluoro-1-(5-methylfuran-2-yl)propy...)
Affinity DataKi:  6nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248401((S)-3-(2-(2,2-difluoro-1-(4-methylfuran-2-yl)propy...)
Affinity DataKi:  6nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248279((S)-3-(3,4-dioxo-2-(2,2,2-trifluoro-1-(furan-2-yl)...)
Affinity DataKi:  6nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50236053((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211454((R)-3-(2-(1-(4-ethylfuran-2-yl)propylamino)-3,4-di...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211458((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)propy...)
Affinity DataIC50: 7.30nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248084((R)-2-hydroxy-N,N-dimethyl-3-(4-(1-(5-methylfuran-...)
Affinity DataKi:  7.5nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211457(3-(2-((R)-1-(4-sec-butylfuran-2-yl)propylamino)-3,...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248545((S)-3-(2-(1-(benzo[d][1,3]dioxol-5-yl)-2,2,2-trifl...)
Affinity DataKi:  8nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211464((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(4-methylfuran-...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248280((S)-3-(3,4-dioxo-2-(2,2,2-trifluoro-1-(5-methylfur...)
Affinity DataKi:  9nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248456((S)-3-(3,4-dioxo-2-(2,2,3,3,3-pentafluoro-1-(5-met...)
Affinity DataKi:  10nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211455((R)-3-(2-(1-(4-tert-butylfuran-2-yl)propylamino)-3...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211462((R)-3-(2-(cyclopropyl(4-isopropylfuran-2-yl)methyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50200882((R)-3-(2-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211452((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)-2-me...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248113((R)-N-(2-cyanoethyl)-3-(4-(2,2-dimethyl-1-(5-methy...)
Affinity DataKi:  13nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50247950((R)-2-hydroxy-N,N-dimethyl-3-(4-(1-(5-methylfuran-...)
Affinity DataKi:  13nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248082((R)-2-hydroxy-N,N-dimethyl-3-(4-(2-methyl-1-(5-met...)
Affinity DataKi:  14nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248115((R)-N-(2-cyanoethyl)-3-(4-(1-(furan-2-yl)-2,2-dime...)
Affinity DataKi:  14nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211448((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)-2,2-...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211461((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(4-(4-morpholin...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248038((R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataKi:  14nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50187003(CHEMBL214047 | CHEMBL218964 | 3-(3,4-dioxo-2-(pent...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248037((R)-2-hydroxy-N,N-dimethyl-3-(4-(2-methyl-1-(5-met...)
Affinity DataKi:  15nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248039((R)-3-(4-(1-(furan-2-yl)-2,2-dimethylpropylamino)-...)
Affinity DataKi:  15nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248335(3-(2-((1S,2S)-2-fluoro-1-(5-methylfuran-2-yl)propy...)
Affinity DataKi:  16nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50211463((S)-3-(3,4-dioxo-2-(2,2,2-trifluoro-1-(4-isopropyl...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248591((R)-3-(4-(cyclopropyl(phenyl)methylamino)-1,2,5-th...)
Affinity DataKi:  16nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50200880(2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248083((R)-(3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)prop...)
Affinity DataKi:  18nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM385540(3-{4-Chloro-2-hydroxy-3-methane[(N-methyl)sulfoxim...)
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM385541(US10287278, Example 3 | US10647706, Example 3)
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248590((R)-3-(4-(1-(3,5-difluorophenyl)propylamino)-1,2,5...)
Affinity DataKi:  20nMAssay Description:Displacement of IL8 from CXCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM441948(US10647706, Example 1)
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM291181(6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfu...)
Affinity DataIC50: 20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
US Patent

TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM385548(US10287278, Example 10 | US10647706, Example 10)
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetC-X-C chemokine receptor type 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248502((S)-3-(2-(1-(4-chlorofuran-2-yl)-2,2,2-trifluoroet...)
Affinity DataKi:  20nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Displayed 1 to 50 (of 539 total ) | Next | Last >>
Jump to: