Compile Data Set for Download or QSAR
Report error Found 483 of affinity data for UniProtKB/TrEMBL: P29350
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 0.335nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 16nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 18nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50: 30nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162441((4S)-4-amino-4-[({[(1S)-1-{[(7R,10R,13S,16S)-7-{[(...)
Affinity DataKd:  110nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162435(H-Glu-Gly-Leu-Asn-pTyr-Nle-Val-Phe-NH2 | CHEMBL274...)
Affinity DataKd:  120nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50: 130nMAssay Description:Inhibition of PTPN6 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162437((4S)-4-amino-4-[({[(1S)-1-{[(8R,11R,14S,17S)-8-{[(...)
Affinity DataKd:  210nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM680881(US20240199525, Compound BPDA6)
Affinity DataIC50: 216nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM680881(US20240199525, Compound BPDA6)
Affinity DataIC50: 216nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162436((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  230nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162443(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2 | C...)
Affinity DataKd:  250nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162439(H-Glu-Gly-Leu-Asn-pTyr-Hfe-Val-Leu-NH2 | CHEMBL439...)
Affinity DataKd:  270nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50594492(CHEMBL3322530)
Affinity DataIC50: 290nMAssay Description:Inhibition of human SHP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162448(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(betaPh)-NH2 | C...)
Affinity DataKd:  290nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50335865(6-Hydroxy-2-(4-methoxyphenyl)-3-(1-(4-(naphthalen-...)
Affinity DataIC50: 335nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM152210(US8987474, NSC-87877)
Affinity DataIC50: 355nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 355nMAssay Description:Inhibition of recombinant GST-fused human SHP1 (205 to 597 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 360nMAssay Description:Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 360nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50335867(3-(1-(4-(4-Chloronaphthalen-1-ylamino)-4-oxobutyl)...)
Affinity DataIC50: 378nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50335868(6-Hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataIC50: 408nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50335870(6-Hydroxy-3-(1-(4-(6-methoxybenzo[d]thiazol-2-ylam...)
Affinity DataIC50: 486nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162449(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-NH2 | CHEMBL269...)
Affinity DataKd:  530nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162444(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-NH2 | CHEMBL273...)
Affinity DataKd:  690nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50246668(3-(benzo[d][1,3]dioxol-5-yl)-2-(5-((4aR,6aS,6bR,8a...)
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50425815(CHEMBL2316908)
Affinity DataIC50: 760nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50290925(CHEMBL4175748)
Affinity DataIC50: 850nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50246745(3-(4-Carboxy-benzyloxy)-28-[4-butyric ((S)-1-carbo...)
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162446((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  900nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50436358(CHEMBL2396718)
Affinity DataIC50: 910nMAssay Description:Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162442(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-NH2 | CHEMBL386...)
Affinity DataKd:  1.00E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50: 1.00E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162445(H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-Val-leu-NH2 | C...)
Affinity DataKd:  1.08E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50290909(CHEMBL4164960)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Vanadates | Sodium orthovanadate (S...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50054344(US9522881, 11a-1 L97M74 | CHEMBL3319356 | US984453...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50162440(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-NH2 | CHEMBL371...)
Affinity DataKd:  1.44E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50054344(US9522881, 11a-1 L97M74 | CHEMBL3319356 | US984453...)
Affinity DataIC50: 1.44E+3nMAssay Description:For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50512277(CHEMBL4445615)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM681986(US20240199525, Compound BPDA10)
Affinity DataIC50: 1.80E+3nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546233(CHEMBL4757579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP1 (222 to 535 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50: 1.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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