Compile Data Set for Download or QSAR
Report error Found 418 of affinity data for UniProtKB/TrEMBL: Q05940
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611952(US11718618, Compound 4-119 | (2R,3R,11bR)-9- (cycl...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611939(US11718618, Compound 4-90 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611867(US11718618, Compound 4-23 | 1-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  0.410nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611873(US11718618, Compound 4-28 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.480nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611905(US11718618, Compound 4-56 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.520nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611877(US11718618, Compound 4-32 | (2R,3R,11bR)-9-cyclobu...)
Affinity DataKi:  0.590nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611937(US11718618, Compound 4-88 | (2R,3R,11bR)-9- (cyclo...)
Affinity DataKi:  0.680nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611954(US11718618, Compound 4-121 | (2R,3R,11bR)-9-[(2,2-...)
Affinity DataKi:  0.820nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611906(US11718618, Compound 4-57 | (2R,3R,11bR)-9-{[1- (d...)
Affinity DataKi:  0.930nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611872(US11718618, Compound 4-27 | (2R,3R,11bR)-9-cyclopr...)
Affinity DataKi:  1nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611856(US11718618, Compound 4-15 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611900(US11718618, Compound 4-55 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611895(US11718618, Compound 4-50 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611953(US11718618, Compound 4-120 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611908(US11718618, Compound 4-59 | 5-({[(2R,3R,11bR)-3-(2...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611876(US11718618, Compound 4-31 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611950(US11718618, Compound 4-117 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611854(US11718618, Compound 4-13 | (2R,3R,11bR)-9-(2,2- d...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611889(US11718618, Compound 4-44 | 2-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611842(US11718618, Compound 4-1 | (2R,3R,11bR)-3-(2,2- di...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611897((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(methoxy- d...)
Affinity DataKi:  2.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611855(US11718618, Compound 4-14 | (2R,3R,11bR)-9-(2,2- d...)
Affinity DataKi:  2.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611909(US11718618, Compound 4-60 | (2R,3R,11bR)-9-(benzyl...)
Affinity DataKi:  3.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611853(US11718618, Compound 4-12 | (2S,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  3.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611910(US11718618, Compound 4-61 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  3.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611911(US11718618, Compound 4-62 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  3.70nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611883(US11718618, Compound 4-38 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  3.70nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611912(US11718618, Compound 4-63 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  4.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611900(US11718618, Compound 4-55 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  4.80nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611888(US11718618, Compound 4-43 | 2-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  4.80nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM516376(US11053242, Compound 1-1)
Affinity DataKi:  5.20nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611913(US11718618, Compound 4-64 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  5.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611860(US11718618, Compound 4-18 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  5.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611869(US11718618, Compound 4-25 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  5.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611948(US11718618, Compound 4-115 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  6.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611897((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(methoxy- d...)
Affinity DataKi:  6.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611890(US11718618, Compound 4-45 | 1-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  7.30nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611861(US11718618, Compound 4-19 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  8.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611914(US11718618, Compound 4-65 | (2R,3R,11bR)-9-(2-chlo...)
Affinity DataKi:  8.70nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611896(US11718618, Compound 4-51 | (2R,3R,11bR)-9-(3,3-di...)
Affinity DataKi:  9.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM516505(US11053242, Compound 5-50)
Affinity DataKi: <10nMAssay Description:The human Ki's for the compounds listed in Table 11 were determined using a slightly modified procedure shown below (see data in column under the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetSynaptic vesicular amine transporter(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM516511(US11053242, Compound 6-1)
Affinity DataKi: <10nMAssay Description:The human Ki's for the compounds listed in Table 11 were determined using a slightly modified procedure shown below (see data in column under the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

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