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Found 517 with Last Name = 'diaz' and Initial = 'jl'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26236(CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-d...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26250(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(pyrrolid...)
Affinity DataKi:  0.260nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252721(1-(Cyclohexylmethyl)-6-methoxy-6,7-dihydrospiro[pi...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252946(1-Benzyl-6-methoxy-6,7-dihydrospiro[piperidine-4,4...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26256(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methox...)
Affinity DataKi:  0.440nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26255(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(3-methox...)
Affinity DataKi:  0.470nM ΔG°:  -52.7kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26251(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(piperidi...)
Affinity DataKi:  0.560nM ΔG°:  -52.3kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26235(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-fluoro-3-...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26249(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(dimethyl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252759(1-(4-Fluorobenzyl)-6-methoxy-6,7-dihydrospiro[pipe...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26253(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methyl...)
Affinity DataKi:  0.710nM ΔG°:  -51.7kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26254(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-{6-[(2-metho...)
Affinity DataKi:  0.720nM ΔG°:  -51.7kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26247(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(morpholi...)
Affinity DataKi:  0.830nM ΔG°:  -51.3kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26234(CHEMBL486950 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.920nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252761(6-Methoxy-1-(3-methylbut-2-enyl)-6,7-dihydrospiro[...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252722(6-Methoxy-1-(3-methylbutyl)-6,7-dihydrospiro[piper...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50108653(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252763(6-Methoxy-1-pentyl-6,7-dihydrospiro[piperidine-4,4...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26241(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypy...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26257(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-hydrox...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252760(6'-methoxy-1-(thien-2-ylmethyl)-6',7'-dihydrospiro...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252758(3'-methoxy-1-[(4-methoxyphenyl)methyl]-3',4'-dihyd...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26252(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(1,4-oxaz...)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26237(CHEMBL458242 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252724(3-Methoxy-1-(3-phenylpropyl)-6,7-dihydrospiro[pipe...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26238(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-hydroxypy...)
Affinity DataKi:  2.90nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26245(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(morpholi...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26239(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(2-methox...)
Affinity DataKi:  3.10nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26240(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypy...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252762(1-Butyl-6-methoxy-6,7-dihydrospiro[piperidine-4,4-...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252948(6-Methoxy-1-octyl-6,7-dihydrospiro[piperidine-4,4-...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252947(6-Methoxy-1-(2-phenylethyl)-6,7-dihydrospiro[piper...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287137(1-(1-(2-(azepan- 1-yl)ethyl)-1H- pyrazolo[3,4- d]p...)
Affinity DataKi:  6.70nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133876((S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity of the compound was tested against caspase-3 (Csp-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26250(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(pyrrolid...)
Affinity DataKi:  7.20nMAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26242(methyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-me...)
Affinity DataKi:  7.40nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM50252725(3-Methoxy-1-(4-phenylbutyl)-6,7-dihydrospiro[piper...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26243(ethyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-met...)
Affinity DataKi:  7.80nM ΔG°:  -45.8kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26248(N-[6-(6-aminopyridin-2-yl)-2-(3,5-dimethyl-1H-pyra...)
Affinity DataKi:  7.90nM ΔG°:  -45.8kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287138(1-(1-(2-(azepan- 1-yl)ethyl)-1H- pyrazolo[3,4- d]p...)
Affinity DataKi:  9.20nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287087(N-(1-(2-(azepan-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataKi:  9.20nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287101(N-(1-(2-(Azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataKi:  9.40nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287111(N-(1-(2-(azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataKi:  11.1nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Bioscience

LigandPNGBDBM26246(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[2-(morpholi...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287140(N-(1-(2-(4-tert- butylpiperidin-1-yl)ethyl)- 1H-py...)
Affinity DataKi:  12.2nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287088(N-(1-[2-(Piperidin-1- yl)ethyl]-1H-pyrazolo[3,4- d...)
Affinity DataKi:  12.7nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287135(1-(1-(2-(azepan-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataKi:  12.8nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287097(N-(1-(2-(Azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataKi:  13.1nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster

Curated by ChEMBL
LigandPNGBDBM287136(1-(1-(2-(azepan- 1-yl)ethyl)-1H- pyrazolo[3,4- d]p...)
Affinity DataKi:  14.9nMpH: 7.4Assay Description:Brain membrane preparation and binding assays for the σ1-receptor were performed as described (DeHaven-Hudkins, D. L., L. C. Fleissner, and F. Y...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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