Compile Data Set for Download or QSAR
Report error Found 313 of affinity data for UniProtKB/TrEMBL: P00378
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  0.5nMAssay Description:Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with chicken dihydrofolate reductase using equation 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  0.600nMAssay Description:Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with chicken dihydrofolate reductase using equation 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405088(CHEMBL31004)
Affinity DataKi:  6.80nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 19nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405093(CHEMBL33066)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405055(CHEMBL283173)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50226274(CHEMBL3349020)
Affinity DataIC50: 19nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405399(CHEMBL2051989)
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405399(CHEMBL2051989)
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405065(CHEMBL286571)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291768(6,6-Dimethyl-1-(3-phenylselanylmethyl-phenyl)-1,6-...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50004544(2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...)
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405401(CHEMBL2051990)
Affinity DataIC50: 22nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291778(N-{3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazi...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405041(CHEMBL33633)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291782(3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291807(1-[3-(4-Chloro-benzylsulfanyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405038(CHEMBL33697)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291805(6,6-Dimethyl-1-{3-[4-(3-trifluoromethyl-phenoxy)-b...)
Affinity DataKi:  29nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405043(CHEMBL7191 | 1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291804(1-(3-Benzylsulfanyl-phenyl)-6,6-dimethyl-1,6-dihyd...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405070(CHEMBL30681)
Affinity DataKi:  32nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405095(CHEMBL433045)
Affinity DataKi:  32nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50025007(2-{4-[2-(2,4-Diamino-7,8-dihydro-pteridin-6-yl)-et...)
Affinity DataIC50: 34nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291794(6,6-Dimethyl-1-(3-phenylsulfanylmethyl-phenyl)-1,6...)
Affinity DataKi:  34nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50025008(2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6...)
Affinity DataIC50: 34nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291766(1-[3-(3-Isopropyl-phenoxymethyl)-phenyl]-6,6-dimet...)
Affinity DataKi:  34nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291771({3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-...)
Affinity DataKi:  35nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405089(CHEMBL268414)
Affinity DataKi:  36nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405052(CHEMBL283916)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405036(CHEMBL33179)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405046(CHEMBL6962)
Affinity DataKi:  42nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405102(CHEMBL30475)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50090054(1-(3-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  44nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405066(CHEMBL268088)
Affinity DataKi:  45nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405072(CHEMBL33010)
Affinity DataKi:  45nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405040(CHEMBL30594)
Affinity DataKi:  47nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405074(CHEMBL34627)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405398(CHEMBL2051991)
Affinity DataIC50: 50nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405398(CHEMBL2051991)
Affinity DataIC50: 50nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291783(1-[3-(3-Methoxy-phenoxymethyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  51nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405042(CHEMBL282754)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291802(1-[3-(3-Ethyl-phenoxymethyl)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  54nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405037(CHEMBL33558)
Affinity DataKi:  58nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405099(CHEMBL33750)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405085(CHEMBL6771)
Affinity DataKi:  63nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405068(CHEMBL34274)
Affinity DataKi:  65nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291789(1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  66nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50291792(4-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  66nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50405092(CHEMBL266025)
Affinity DataKi:  71nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
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