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TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035236(3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propi...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50: 0.25nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50303326((S)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035239(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50084905({1-[2-Dibenzofuran-3-yl-1-(1H-tetrazol-5-yl)-ethyl...)
Affinity DataIC50: 2.60nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50084905({1-[2-Dibenzofuran-3-yl-1-(1H-tetrazol-5-yl)-ethyl...)
Affinity DataIC50: 2.60nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035251(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-succi...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50084903({[2-Dibenzofuran-3-yl-1-(1H-tetrazol-5-yl)-ethylam...)
Affinity DataIC50: 6nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50084897(3-Dibenzofuran-3-yl-2-[3-dibenzofuran-3-yl-2-(phos...)
Affinity DataIC50: 6.40nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035240((2-Hydroxycarbamoyl-3-methyl-butyrylamino)-acetic ...)
Affinity DataIC50: 6.80nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50159366((2S,4R)-4-Acetylsulfanyl-2-(2,4,5-trifluoro-benzyl...)
Affinity DataIC50: 6.90nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50303328((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1{[(benzyloxy)c...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50064110(CHEMBL147847 | 2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2...)
Affinity DataIC50: 8nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50303323((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  8nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50119751(2-{[1-(2-Mercapto-4-methyl-pentanoylamino)-cyclope...)
Affinity DataIC50: 9.5nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50119742(2-{[1-(2-Mercapto-4-methyl-pentanoylamino)-cyclope...)
Affinity DataIC50: 9.80nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50119742(2-{[1-(2-Mercapto-4-methyl-pentanoylamino)-cyclope...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of Homo sapiens (human) endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115848((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((S)-5-m...)
Affinity DataKi:  10nMAssay Description:Inhibition constant against endothelin converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115846((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of endothelin converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50159365((3R,5S)-5-{[(2,5-difluorobenzyl)amino]methyl}-1-(5...)
Affinity DataIC50: 10.4nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21643([3-(naphthalen-1-yl)-1-{[(1S)-2-(4-phenylphenyl)-1...)
Affinity DataKi:  10.8nMAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50488983(CHEMBL2297552)
Affinity DataIC50: 11nMAssay Description:Inhibition of Homo sapiens (human) endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50091882(3-Biphenyl-4-yl-2-{[1-(2-mercapto-pentanoylamino)-...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50488971(CHEMBL2297562)
Affinity DataIC50: 11nMAssay Description:Inhibition of Homo sapiens (human) endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50091882(3-Biphenyl-4-yl-2-{[1-(2-mercapto-pentanoylamino)-...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50091882(3-Biphenyl-4-yl-2-{[1-(2-mercapto-pentanoylamino)-...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity was tested against Endothelin converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50091878((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-3-methox...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50064114((S)-3-Biphenyl-4-yl-2-[(S)-5-(2-fluoro-phenyl)-2-(...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50084898(2-[3-Dibenzofuran-3-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50: 13nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50303322((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  14nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50064125((S)-3-Cyclohexyl-2-[(S)-5-(2,4-difluoro-phenyl)-2-...)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  14nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50159364(isopropyl (2S,4R)-2-{[(2,5-difluorobenzyl)amino]me...)
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035237(2-(2-Hydroxycarbamoylmethyl-3-methyl-butyrylamino)...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant ECE1 by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50291561({1-[(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethyl...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition against recombinant human Endothelin converting enzyme 1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50064109({1-[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamin...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50064109({1-[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamin...)
Affinity DataIC50: 17nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035237(2-(2-Hydroxycarbamoylmethyl-3-methyl-butyrylamino)...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115843((2S)-2-[(2R)-2-[(1R)-5-bromo-2,3-dihydro-1H-inden-...)
Affinity DataKi:  18nMAssay Description:In vitro inhibition of endothelin converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50488990(CHEMBL2297556)
Affinity DataIC50: 19nMAssay Description:Inhibition of Homo sapiens (human) endothelin converting enzyme-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50091888((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-4-methyl...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115841(3-(1H-Indol-3-yl)-2-[3-mercapto-2-(5-methoxy-indan...)
Affinity DataKi:  22nMAssay Description:In vitro inhibition of endothelin converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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