Compile Data Set for Download or QSAR
Report error Found 19 of affinity data for UniProtKB/TrEMBL: P48303
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250631BDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.0286nMAssay Description:Displacement of [33P]-S1P from rat S1P1 receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063864BDBM50063864(CHEMBL3403619 | US10676467, Compound TZ 50 13)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at rat S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50041983BDBM50041983(CHEMBL3359523)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50041982BDBM50041982(CHEMBL3359522)
Affinity DataEC50:  0.0720nMAssay Description:Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 197654BDBM197654(US9216972, 7)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at rat S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgamma-S binding measured after 45 mins by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50041691BDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.320nMAssay Description:Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250631BDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.772nMAssay Description:Displacement of [33P]-S1P from rat S1P1 receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357764BDBM50357764(CHEMBL1916399)
Affinity DataEC50:  1nMAssay Description:Agonist activity at rat S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357781BDBM50357781(CHEMBL1916559)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at rat S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386853BDBM50386853(CHEMBL2048287)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386853BDBM50386853(CHEMBL2048287)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364607BDBM50364607(CHEMBL1951304)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363937BDBM50363937(CHEMBL1951588)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363937BDBM50363937(CHEMBL1951588)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386859BDBM50386859(CHEMBL2048293)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386859BDBM50386859(CHEMBL2048293)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50445387BDBM50445387(CHEMBL3105479)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed