PMID

Data

Article Title

Organization

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.

Chang Gung Memorial Hospital

Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1).

University of Bonn

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.

University of Regensburg

Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.

The Hong Kong Polytechnic University

Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4.

Radboud University Nijmegen Medical Centre

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.

Universit£

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

Universit£

Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.

Institute of Organic Synthesis

Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).

University of Bonn

Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.

University of Bonn

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.

Universit£

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.

Universit£

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.

Universit£

Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.

Academic Hospital Vrije Universiteit

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

Deutsches Krebsforschungszentrum

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

Deutsches Krebsforschungszentrum

Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids.

Queen'S University

ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.

Queen'S University

Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.

Wake Forest University School of Medicine

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).

Laboratoire De Pharmacologie-Toxicologie Inra

Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.

Eli Lilly

4-Substituted-2-phenylquinazolines as inhibitors of BCRP.

University of Bonn

Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

Gilead Sciences

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein.

Cnrs/Universit£

A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.

University of Bonn

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.

Universit£

Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors.

Kakatiya University

Interaction potential of etravirine with drug transporters assessed in vitro.

University Hospital Heidelberg

Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

University of Bonn

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.

Universita Degli Studi Di Torino

Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).

University of Bonn

Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

The Hong Kong Polytechnic University

Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.

University of Bonn

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1.

Institut De Biologie Et Chimie Des ProtéInes

Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).

Eli Lilly

Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine.

M.D. University

Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.

Hong Kong Polytechnic University

Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.

Xenova

Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance.

Xenova

Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).

Hong Kong Polytechnic University

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Athenex

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.

University of Bonn

Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities.

Umm Al-Qura University

Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists.

Rheinische Friedrich-Wilhelms-University Bonn

Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.

Rheinische Friedrich-Wilhelms-University of Bonn

Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).

University of Regensburg

Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.

Xenova

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Pfizer

Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.

Taipei Chang Gung Memorial Hospital

Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).

University of Bonn

Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.

Rheinische Friedrich-Wilhelms-University of Bonn

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.

Universit£

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.

University of Florence

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.

University of Florence

Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach.

Rheinische Friedrich-Wilhelms-University of Bonn

Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.

University of Bonn

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

Universit£

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Hong Kong Polytechnic University

Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1.

Zhejiang University

ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1.

University Hospital Groningen

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Deutsches Krebsforschungszentrum

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.

Deutsches Krebsforschungszentrum

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

Queen'S University

Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump.

University of Texas M. D. Anderson Cancer Center

Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".

Hong Kong Polytechnic University

Monoterpene indole alkaloid azine derivatives as MDR reversal agents.

Universidade De Lisboa

Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).

University of Bonn

4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).

University of Bonn