BDBM16173 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride::3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide::Amiloride::Amipramidin::CHEMBL945

SMILES c1(c(nc(c(n1)Cl)N)N)C(=O)NC(=N)N

InChI Key InChIKey=XSDQTOBWRPYKKA-UHFFFAOYSA-N

Data  45 KI  33 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 16173   

TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 776nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Parion Sciences

US Patent
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 781nMAssay Description:One assay used to assess mechanism of action and/or potency of the compounds of the present invention involves the determination of lumenal drug inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Bovine)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Tokushima University

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 2.08E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of mouse uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  2.31E+3nMAssay Description:Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human kidney uPA using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  2.43E+3nMAssay Description:Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  2.51E+3nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  3.28E+3nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSolute carrier family 22 member 2(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  4.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 4.74E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  5.30E+3nM ΔG°:  -7.19kcal/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 6.63E+3nMAssay Description:The PKD HTS assay was developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) as part of the Molecular Library Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 6.88E+3nMpH: 7.2 T: 2°CAssay Description:The PKD HTS assay was developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) as part of the Molecular Library Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetSolute carrier family 22 member 1(Rat)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  6.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of urokinase-type plasminogen activator using Glt-Gly-Arg-AMC as substrate by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of uPA (unknown origin) using L-pyroglutamyl-glycyl-L-arginine-p-nitro-anilide as susbtrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of uPA (unknown origin) using L-pyroglutamyl-glycyl-L-arginine-p-nitroanilide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-1 adrenergic receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetVoltage-dependent calcium channel gamma-1 subunit(Human)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetCalcium release-activated calcium channel protein 1(Human)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetMembrane primary amine oxidase(Rat)
University of Technology

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory activity against porcine kidney amine oxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetGlycine amidinotransferase, mitochondrial(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine 1D receptor(Bovine)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Pig)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Center For Bio-Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2011
Entry Details Article
PubMed
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