BDBM405274 1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)methyl)-5-(6-methoxypyridazin-3-yl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)phenyl)-3-methoxyurea::US10344034, Example 11::US10633388, Example 11

SMILES CONC(=O)Nc1ccc(cc1)-n1nc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nn3)c(=O)c2c1CN(C)C

InChI Key InChIKey=IMJPTZZFUZNJLV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 405274   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  4.95nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin releasing hormone receptor(Macaca fascicularis (Crab-eating macaque) (Cynomol...)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  78.6nMAssay Description:Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Rabbit)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.570nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  4.95nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin-releasing hormone II receptor(Green monkey)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.570nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Oryctolagus cuniculus (Rabbit))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.570nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
In DepthDetails US Patent