BDBM50021574 BMS-907351::CABOZANTINIB::CHEBI:72317::Cabometyx::Cometriq::US10183928, Cabozantinib::US10202365, Compound Cabozantinib::US10227329, Compound Cabozantinib::US10273211, Compound Cabozantinib::US10464902, Cabozantinib::US10774070, Compound Cabozantinib::US11279688, Compound Cabozantinib::XL-184::cabozantinib s-malate
SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
InChI Key InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50021574
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of recombinant human full length VEGFR2 using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length FLT3 using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human full length c-MET using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human full length KIT using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human full length RET using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human full length TIE2 using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length AXL using poly (Glu, Tyr) as substrate by alpha screen assayMore data for this Ligand-Target Pair