BDBM50021574 BMS-907351::CABOZANTINIB::CHEBI:72317::Cabometyx::Cometriq::US10183928, Cabozantinib::US10202365, Compound Cabozantinib::US10227329, Compound Cabozantinib::US10273211, Compound Cabozantinib::US10464902, Cabozantinib::US10774070, Compound Cabozantinib::US11279688, Compound Cabozantinib::XL-184::cabozantinib s-malate
SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
InChI Key InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50021574
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant MET kinase domain (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant VEGFR2 kinase domain (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of recombinant MET kinase domain (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of MET in human MKN-45 cells assessed as reduction in HGF-mediated autophosphorylationMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Central China Normal University
Curated by ChEMBL
Central China Normal University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant VEGFR2 kinase domain (unknown origin)More data for this Ligand-Target Pair