BindingDB BDBM50021574 BMS-907351::CABOZANTINIB::CHEBI:72317::Cabometyx::Cometriq::US10183928, Cabozantinib::US10202365, Compound Cabozantinib::US10227329, Compound Cabozantinib::US10273211, Compound Cabozantinib::US10464902, Cabozantinib::US10774070, Compound Cabozantinib::US11279688, Compound Cabozantinib::XL-184::cabozantinib s-malate

BDBM50021574 BMS-907351::CABOZANTINIB::CHEBI:72317::Cabometyx::Cometriq::US10183928, Cabozantinib::US10202365, Compound Cabozantinib::US10227329, Compound Cabozantinib::US10273211, Compound Cabozantinib::US10464902, Cabozantinib::US10774070, Compound Cabozantinib::US11279688, Compound Cabozantinib::XL-184::cabozantinib s-malate

SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC

InChI Key InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N

Data 1 KI 155 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50021574

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)

IC50: 0.600nMAssay Description:Inhibition of FLT3 (unknown origin) phosphorylationMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid Similars

Details PubMed

Filter my 157 hits

Targets 23▿
- Proto-oncogene tyrosine-protein kinase receptor Ret 37
- Hepatocyte growth factor receptor 31
- Vascular endothelial growth factor receptor 2 27
- Receptor-type tyrosine-protein kinase FLT3 10
- Mast/stem cell growth factor receptor Kit 9
- Tyrosine-protein kinase receptor UFO 9
- Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] 6
- Angiopoietin-1 receptor 5
- Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] 3
- Epidermal growth factor receptor 3
- Vascular endothelial growth factor receptor 1 3
- Fibroblast growth factor receptor 1 2
- Vascular endothelial growth factor receptor 3 2
- Coiled-coil domain-containing protein 6 1
- Macrophage-stimulating protein receptor 1
- Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Ferrochelatase, mitochondrial [R115L] 1
- Insulin-like growth factor 1 receptor 1
- Proto-oncogene tyrosine-protein kinase Src 1
- SAFB-like transcription modulator 1
- High affinity nerve growth factor receptor 1
- Potassium voltage-gated channel subfamily H member 2 1
- Platelet-derived growth factor receptor alpha 1
- ...
Publications 45▿
- J Med Chem 64: 11747-11773 (2021) 12
- Eur J Med Chem 108: 495-504 (2016) 12
- Eur J Med Chem 146: 368-380 (2018) 9
- Eur J Med Chem 212: (2021) 9
- J Med Chem 59: 8712-8756 (2016) 9
- Bioorg Med Chem 25: 3195-3205 (2017) 9
- Eur J Med Chem 158: 814-831 (2018) 8
- Eur J Med Chem 138: 942-951 (2017) 7
- US Patent US10273211 (2019) 6
- J Med Chem 59: 358-73 (2016) 6
- Eur J Med Chem 112: 20-32 (2016) 4
- Bioorg Med Chem Lett 24: 3351-5 (2014) 4
- Bioorg Med Chem 24: 3353-8 (2016) 4
- US Patent US10774070 (2020) 3
- Eur J Med Chem 143: 1148-1164 (2018) 3
- US Patent US10227329 (2019) 3
- Eur J Med Chem 208: (2020) 3
- US Patent US10202365 (2019) 3
- J Med Chem 65: 15374-15390 (2022) 3
- US Patent US11279688 (2022) 2
- Bioorg Med Chem 25: 6674-6679 (2017) 2
- US Patent US10183928 (2019) 2
- Eur J Med Chem 179: 916-935 (2019) 2
- Eur J Med Chem 83: 581-93 (2014) 2
- Eur J Med Chem 223: (2021) 2
- ACS Med Chem Lett 11: 497-505 (2020) 2
- Eur J Med Chem 118: 244-9 (2016) 2
- US Patent US10584114 (2020) 2
- Bioorg Chem 72: 116-122 (2017) 2
- Eur J Med Chem 135: 370-381 (2017) 2
- Eur J Med Chem 234: (2022) 1
- Eur J Med Chem 204: (2020) 1
- Eur J Med Chem 224: (2021) 1
- J Med Chem 58: 3672-81 (2015) 1
- ACS Chem Biol 11: 1245-54 (2016) 1
- Bioorg Med Chem Lett 29: 1565-1571 (2019) 1
- Bioorg Med Chem Lett 30: (2020) 1
- US Patent US10464902 (2019) 1
- Bioorg Med Chem Lett 29: (2019) 1
- J Med Chem 64: 2878-2900 (2021) 1
- Bioorg Med Chem 27: 2127-2139 (2019) 1
- Eur J Med Chem 192: (2020) 1
- Bioorg Med Chem Lett 30: (2020) 1
- Bioorg Med Chem Lett 27: 3231-3237 (2017) 1
- Bioorg Med Chem 23: 564-78 (2015) 1
Institutions 27▿
- China Pharmaceutical University 26
- Shenyang Pharmaceutical University 15
- Blueprint Medicines 15
- University Of Arkansas For Medical Sciences 12
- Zhuhai Campus Of Zunyi Medical University 10
- Hangzhou Xixi Hospital 9
- St. John'S University 9
- Sun Yat-Sen University 9
- Central China Normal University 7
- University Of Manchester 6
- Exelixis 6
- Korea Institute Of Science And Technology (Kist) 6
- Sichuan University/Collaborative Innovation Center Of Biotherapy 3
- Jinan University 3
- Fuzhou University 2
- Fudan University 2
- Chinese Academy Of Sciences 2
- Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University) 2
- Hebei University Of Science And Technology 2
- Ontogenesis 1
- Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif) 1
- Technical University of Munich 1
- Nankai University 1
- National Health Research Institutes 1
- University Of Gothenburg 1
- Punjabi University 1
- Shanghai Institute Of Technology 1
Affinity: 0.035 to 4.2E+4 nM▿
- Ki 1
- IC50 155
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1