BDBM50331095 CHEMBL1289494::Tivozanib::US10464902, Tivozanib

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

InChI Key InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N

Data  1 KI  20 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 50331095   

LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of ERK1 phosphorylation in VEGF-stimulated serum-starved human HUVEC cells by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of VEGFR-2 phosphorylation in serum starved human HUVEC cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ERK2 phosphorylation in VEGF-stimulated serum-starved human HUVEC cells by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of VEGFR-1 phosphorylation in serum starved mouse NIH3T3 cells transfected with Flt1 incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of VEGFR-3 phosphorylation in serum starved human HUVEC cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of insulin-R (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of ErbB2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of Flt3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of Jak2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of IGF-1R (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of ErbB4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetFocal adhesion kinase 1(Human)TBA
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of Fak (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR-4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR-3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of c-Kit phosphorylation in serum starved human KU812 cell line incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PDGFR-beta phosphorylation in serum starved human NHDF cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 3.38nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataKi:  6.5nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGFR-3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetEphrin type-B receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant EphB2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 24nMAssay Description:Inhibition of EphB2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetEphrin type-B receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant EphB2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 40nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 42.4nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 49nMAssay Description:Inhibition of PDGFR-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 70nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human MCF7 cells membrane mediated [125I]iodoarylazidoprazosin photolabelling for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 78nMAssay Description:Inhibition of c-Kit (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAngiopoietin-1 receptor(Human)TBA
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 78nMAssay Description:Inhibition of Tie2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetFibroblast growth factor 2(Human)
Nanjing University

LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 114nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 124nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataKd:  259nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 299nMAssay Description:Inhibition of FGFR1 phosphorylation in serum starved human NHDF cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 2(Human)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 340nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 422nMAssay Description:Inhibition of Flt3 phosphorylation in serum starved human EOL1 cells incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
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