BDBM50366824 Avelox::MOXIFLOXACIN::Moxifl-oxacin

SMILES COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1

InChI Key InChIKey=FABPRXSRWADJSP-MEDUHNTESA-N

Data  1 KI  43 IC50

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50366824   

TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataKi:  2.49E+5nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute Of Technology

LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  810nMpH: 7.5Assay Description:Initially, equimolar quantities of about 0.5µM each of E. coli gyraseA and S. aureus gyraseB were incubated for a period of 45 min with salmon sperm ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Mycobacterium smegmatis GyrB ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS cells after 100 mins by inorganic phosphate...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  3.98E+4nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  2.51E+5nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of 6-His-tagged Mycobacterium smegmatis GyrB expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 100 mins in presence of AT...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  3.98E+5nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  7.94E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  3.98E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells transfected with KCNQ1 / Kv1.7 / KvLQT1 and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  3.98E+5nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.58E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.69E+5nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in ATPase activity incu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.17E+5nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.17E+5nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.73E+5nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of supercoiling activity using relaxed pBR322 plasmid as substrate after 3...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  4.98E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB assessed as reduction of enzyme supercoiling activity using relaxed pBR322 DNA substrat...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  2.27E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase gyrA S84L mutant supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to super...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  2.75E+4nMAssay Description:Inhibition of Staphylococcus aureus wild-type DNA gyrase supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to supercoiled ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of Staphylococcus aureus wild type DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >1.27E+6nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrBMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli)
Universit£

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase GyrA/GyrBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyraseMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of Staphylococcus aureus ATTC 25923 DNA gyraseMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in mammalian cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed