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Report error Found 6332 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 6'
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34155(indenylsulfonamide, 26)
Affinity DatapH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34157(indenylsulfonamide, 29)
Affinity DatapH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34160(isomeric mixture (70% 7-indenyl, 30% 4-indenyl) | ...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at serotonin 5-HT6R receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50499310(CHEMBL3736433)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50499311(CHEMBL3736156)
Affinity DataEC50: <5.01E+3nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human 5HT6 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34148(CHEMBL371292 | piperidinylindole, 7)
Affinity DataEC50:  36nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172262(1-(5-Chloro-3-methyl-pyrazol-1-ylmethanesulfonyl)-...)
Affinity DataEC50:  89.5nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172281(1-(2-Fluoro-benzenesulfonyl)-3-(1,2,5,6-tetrahydro...)
Affinity DataEC50:  51nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34148(CHEMBL371292 | piperidinylindole, 7)
Affinity DataEC50:  36nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172278(1-(5-Bromo-thiophene-2-sulfonyl)-3-((R)-1-methyl-p...)
Affinity DataEC50:  103nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172298(1-(3-Fluoro-benzenesulfonyl)-3-(1,2,5,6-tetrahydro...)
Affinity DataEC50:  270nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172302(1-(3,4-Difluoro-benzenesulfonyl)-3-piperidin-3-yl-...)
Affinity DataEC50:  66nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34148(CHEMBL371292 | piperidinylindole, 7)
Affinity DataEC50:  36nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172313(1-(5-Chloro-thiophene-2-sulfonyl)-3-piperidin-3-yl...)
Affinity DataEC50:  58.5nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172296(1-Benzenesulfonyl-3-(1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataEC50:  159nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50172301(1-(4-Fluoro-benzenesulfonyl)-3-(1,2,5,6-tetrahydro...)
Affinity DataEC50:  345nMAssay Description:Effective concentration for cAMP production in HeLa cells expressing human 5-HT6 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataEC50:  1nMAssay Description:Partial agonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217880(3-(3-chloro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hp...)
Affinity DataEC50:  1.68E+3nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217883(3-[(5-chlorothien-2-yl)sulfonyl]-1-piperidin-3-yl-...)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217884(3-[(3-fluorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpy...)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217888(3-(phenylsulfonyl)sulfonyl]-1-piperidin-3-yl-1Hpyr...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217894(1-(1-ethylpiperidin-3-yl)-3-[(3,5-dichlorophenyl)-...)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217885(3-{[3-(trifluoromethyl)phenyl]sulfonyl}-1-piperidi...)
Affinity DataEC50:  273nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217895(1-(1-ethylpiperidin-3-yl)-3-[(3-fluorophenyl)sulfo...)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217899(3-[(3-bromophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyr...)
Affinity DataEC50:  72nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217896(3-[(3-fluorophenyl)sulfonyl]-1-(1-isopropylpiperid...)
Affinity DataEC50:  172nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217901(1-(1-ethylpiperidin-3-yl)-3-[(5-chlorothien-2-yl)-...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217902(3-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfon...)
Affinity DataEC50:  66nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217906(3-benzenesulfonyl-1-(1-methyl-pyrrolidin-3-yl)-1Hp...)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217887(3-[(2-chlorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpy...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217903(3-{[3-(trifluoromethyl)phenyl]sulfonyl}-1-(1-methy...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217917(3-(4-fluoro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hp...)
Affinity DataEC50:  1.65E+3nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217921(3-[(3,5-dichlorophenyl)sulfonyl]-1-piperidin-3-yl-...)
Affinity DataEC50:  297nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217916(3-[(3-chlorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpy...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217893(1-pyrrolidin-3-yl-3-(3-trifluoromethyl-benzenesulf...)
Affinity DataEC50:  520nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217892(3-[(3,5-dichlorophenyl)sulfonyl]-1-(1-methylpiperi...)
Affinity DataEC50:  38.7nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217922(3-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfon...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217925(3-(3-fluoro-benzenesulfonyl)-1-(1-methyl-pyrrolidi...)
Affinity DataEC50:  231nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217890(3-[(5-chlorothien-2-yl)sulfonyl]-1-(1-methylpiperi...)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217900(3-(6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl)-1-p...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217898(3-[(3-fluorophenyl)sulfonyl]-1-(1-methylpiperidin-...)
Affinity DataEC50:  306nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217927(3-[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfon...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217920(3-(3-bromo-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpy...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217926(3-(3-fluoro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hp...)
Affinity DataEC50:  278nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50217897(3-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperidi...)
Affinity DataEC50:  414nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT6 receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
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