Compile Data Set for Download or QSAR
Report error Found 890 Enz. Inhib. hit(s) with Target = 'Ephrin type-A receptor 2'
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538252(CHEMBL4642167)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human EPHA2 using poly[Glu:Tyr] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.800nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.850nMAssay Description:Binding constant for EPHA2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.850nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.850nMAssay Description:Binding constant for EPHA2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 1nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.30nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538266(CHEMBL4649686)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 1.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 2nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538258(CHEMBL4641389)
Affinity DataKi:  2nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of EphA2 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538238(CHEMBL4642849)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538270(CHEMBL4634220)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  2.80nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538273(CHEMBL4634551)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to recombinant human EPHA2 (D596 to G900 residues) expressed in insect cells incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHA2 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  3.60nMAssay Description:Binding constant for EPHA2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for EPHA2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataIC50: 4nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50311316(LDN-211904 | N-(2-chlorophenyl)-6-(piperidin-4-yl)...)
Affinity DataIC50: 4.10nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50: 4.40nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHA2 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538264(CHEMBL4636597)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209861(TAK-901 | 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N...)
Affinity DataIC50: 4.80nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538274(CHEMBL4637644)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538260(CHEMBL4643355)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50588613(CHEMBL5180264)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of EPHA2 (unknown origin) by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538267(CHEMBL4634880)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538272(CHEMBL4636032)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human EPHA2 using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538239(CHEMBL4640044)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538271(CHEMBL4648601)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to human EPHA2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50588611(CHEMBL5180519)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of EPHA2 (unknown origin) by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538263(CHEMBL4643893)
Affinity DataKi:  6.80nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataKd:  6.90nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50588612(CHEMBL5178807)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of EPHA2 (unknown origin) by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataIC50: 7.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50538259(CHEMBL4637500)
Affinity DataKi:  9nMAssay Description:Binding affinity to 6x-His-tagged human EphA2 ecto-domain residues (Lys27 to Asn529 residues) expressed in HEK293 cells incubated for 60 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataKd:  9nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50588607(CHEMBL5177810)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of EPHA2 (unknown origin) by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50240781(CHEMBL4105329)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant EPH-A2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EphA2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50240780(CHEMBL4062877)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant EPH-A2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Bicycletx

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EphA2 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
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