Report error Found 321 Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-I'
Affinity DataEC50: 0.200nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 72 hr by scintillation cou...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 0.900nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 1 hr by scintillation coun...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Affinity DataEC50: 23nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Binding affinity to human EIF4A1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-MycMore data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulinMore data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair





3D Structure (crystal)

























