Compile Data Set for Download or QSAR
Report error Found 3316 Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1'
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50513279(CHEMBL4554455)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590475(CHEMBL5170906)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590490(CHEMBL5198068)
Affinity DataIC50: 0.108nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590479(CHEMBL5196177)
Affinity DataIC50: 0.117nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590489(CHEMBL5176233)
Affinity DataIC50: 0.124nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590488(CHEMBL5206909)
Affinity DataIC50: 0.153nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590483(CHEMBL5187385)
Affinity DataIC50: 0.161nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590484(CHEMBL5190968)
Affinity DataIC50: 0.192nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590485(CHEMBL5177776)
Affinity DataIC50: 0.194nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Mouse)
Cancer Therapeutics Crc

US Patent
LigandPNGBDBM176589(US9120761, 3)
Affinity DataKd:  0.210nMpH: 7.4Assay Description:In running buffer (0.01 M HEPES pH 7.4, 0.15 M NaCl, 0.005% Surfactant P20, mM MgCl2, and 1% DMSO)N-terminally GST-fused purified FAK enzyme was capt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590474(CHEMBL5176990)
Affinity DataIC50: 0.213nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50554439(CHEMBL4752642)
Affinity DataKi:  0.230nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590477(CHEMBL5204729)
Affinity DataIC50: 0.275nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Mouse)
Cancer Therapeutics Crc

US Patent
LigandPNGBDBM176587(US9120761, 1)
Affinity DataKd:  0.290nMpH: 7.4Assay Description:In running buffer (0.01 M HEPES pH 7.4, 0.15 M NaCl, 0.005% Surfactant P20, mM MgCl2, and 1% DMSO)N-terminally GST-fused purified FAK enzyme was capt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590482(CHEMBL5186801)
Affinity DataIC50: 0.296nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155552(US9012461, 28)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590487(CHEMBL5199835)
Affinity DataIC50: 0.315nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590476(CHEMBL5178369)
Affinity DataIC50: 0.315nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418652(4-{[4-({3- [methyl(methylsulfonyl)amino]benzyl} am...)
Affinity DataIC50: 0.380nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155547(US9012461, 23)
Affinity DataIC50: 0.390nMpH: 7.4Assay Description:A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM755771(US20250214967, Compound A6)
Affinity DataIC50: 0.390nMAssay Description:The inhibitory activity of a compound against FAK was determined in a buffer containing 5 mM HEPES, pH 7.5, 0.01% Triton, 0.5 mM EGTA, and 0.01% BRIJ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM755769(N-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoiso...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of a compound against FAK was determined in a buffer containing 5 mM HEPES, pH 7.5, 0.01% Triton, 0.5 mM EGTA, and 0.01% BRIJ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50554449(CHEMBL4750273)
Affinity DataKi:  0.400nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155545(US9012461, 21)
Affinity DataKd:  0.440nMpH: 7.4 T: 2°CAssay Description:Binding parameters of compounds were determined using a Biacore S51 sensor. An anti-GST antibody was immobilized onto a CM5 chip by primary amine-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155537(US9012461, 13)
Affinity DataKd:  0.470nMpH: 7.4 T: 2°CAssay Description:Binding parameters of compounds were determined using a Biacore S51 sensor. An anti-GST antibody was immobilized onto a CM5 chip by primary amine-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50554448(CHEMBL4783568)
Affinity DataKi:  0.470nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM755772(US20250214967, Compound A7)
Affinity DataIC50: 0.470nMAssay Description:The inhibitory activity of a compound against FAK was determined in a buffer containing 5 mM HEPES, pH 7.5, 0.01% Triton, 0.5 mM EGTA, and 0.01% BRIJ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155560(US9012461, 36)
Affinity DataKd:  0.480nMpH: 7.4 T: 2°CAssay Description:Binding parameters of compounds were determined using a Biacore S51 sensor. An anti-GST antibody was immobilized onto a CM5 chip by primary amine-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155525(US9012461, 1)
Affinity DataKd:  0.490nMpH: 7.4 T: 2°CAssay Description:Binding parameters of compounds were determined using a Biacore S51 sensor. An anti-GST antibody was immobilized onto a CM5 chip by primary amine-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM418817(US10450297, Example 317 | US10450297, Example 318 ...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant FAK (unknown origin) by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50246239(N-methyl-N-(2-((2-(1-oxoisoindolin-5-ylamino)-5-(t...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50207359(CHEMBL3892377)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50592745(CHEMBL5188373)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50207351(CHEMBL3965256)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590486(CHEMBL5177168)
Affinity DataIC50: 0.514nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM155529(US9012461, 7 | US9012461, 5)
Affinity DataKd:  0.570nMpH: 7.4 T: 2°CAssay Description:Binding parameters of compounds were determined using a Biacore S51 sensor. An anti-GST antibody was immobilized onto a CM5 chip by primary amine-cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50590473(CHEMBL5192604)
Affinity DataIC50: 0.579nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418649(N-methyl-4-{[4-({2- [methyl(methylsulfonyl)amino]b...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418650(N-ethyl-4-({4-[({3- [methyl(methylsulfonyl)amino]p...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418651(ethyl [4-({4-[({2- [methyl(methylsulfonyl)amino]py...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418609(N-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418610(N-methyl-4-({4-[({6-methyl-2- [methyl(methylsulfon...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418604(3-methoxy-4-({4-[({2- [methyl(methylsuffonyl)amino...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418605(3-methoxy-4-({4-[({6-methyl-2- [methyl(methylsulfo...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418606(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418607(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418634(N-[5-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418603(3-methoxy-4-{[4-{[3- (methylsulfonyl)benzyl]amino}...)
Affinity DataIC50: 0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

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