Compile Data Set for Download or QSAR
Report error Found 198 Enz. Inhib. hit(s) with Target = 'Melanin-concentrating hormone receptor 2'
LigandPNGBDBM50360702(CHEMBL1934121)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360704(CHEMBL1934123)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM85789([Phe13,Tyr19]MCH)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50360683(CHEMBL1934130)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360708(CHEMBL1934127)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM85788(hMCH | MCH)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50295693(CHEMBL557629)
Affinity DataKi:  1.60nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM85951(hAc-MCH(6-16)-NH2)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85788(hMCH | MCH)
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50172440(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50360691(CHEMBL1934109)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360694(CHEMBL1934112)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50172432(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Affinity DataIC50: 4.5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172425(N-[2-(4-Amino-piperidin-1-yl)-4-methyl-quinolin-6-...)
Affinity DataIC50: 4.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM85956(N-Me-Arg11)
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50172418(N-[4-Methyl-2-(4-pyrrolidin-1-yl-piperidin-1-yl)-q...)
Affinity DataIC50: 6.30nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172441((E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl...)
Affinity DataIC50: 6.40nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172416(N-[2-(2,5-Diaza-bicyclo[2.2.1]hept-2-yl)-4-methyl-...)
Affinity DataIC50: 6.80nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172413(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Affinity DataIC50: 6.80nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172427(N-[2-(3-Dimethylamino-propylamino)-4-methyl-quinol...)
Affinity DataIC50: 7.10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50360706(CHEMBL1934125)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50172442((E)-N-[2-(2-Dimethylamino-ethylamino)-4-methyl-qui...)
Affinity DataIC50: 8.40nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50: 8.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172434(Acetic acid 2-({6-[2-(3,4-dichloro-phenoxy)-acetyl...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50150709(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50360697(CHEMBL1934116)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50301708((Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human MCH2RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50360707(CHEMBL1934126)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360709(CHEMBL1934128)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50172438(N-{2-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-4-met...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50360683(CHEMBL1934130)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360703(CHEMBL1934122)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM85976(N-Me-Nle8)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85972(Gva6,desLeu9,Ava14,15)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85950(D-Cys7,Ava14,15)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85953(D-Arg6,Ava9,10)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85949(Gva6,D-Cys7,Ava14,15)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50360696(CHEMBL1934114)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM85974(Gva6,Ala8,Ava14,15)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85947(Gva6,betaAla14,15 | Gva6,Ava14,15)
Affinity DataKi:  34nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85971(Gva6,Ala12,Ava14,15)
Affinity DataKi:  35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85961(N-Me-Gly10)
Affinity DataKi:  37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85969(Ala8,Ava14,15)
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85968(Gva6,Ava14,15, OH)
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85963(Gva6,Ava9,10,Ava14,15)
Affinity DataKi:  40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85973(Gpr6,Ava14,15)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
LigandPNGBDBM85966(Gva6,Gly14,15)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2012
Entry Details Article
PubMed
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