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Report error Found 1877 Enz. Inhib. hit(s) with Target = 'Urokinase-type plasminogen activator'
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity towards urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147093(6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENY...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of uPA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147093(6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENY...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards Urokinase-type plasminogen activator (urokinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147093(6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENY...)
Affinity DataKi:  0.631nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034582(Peptide boronate | CHEMBL2448441)
Affinity DataKi:  0.848nMAssay Description:Binding affinity against Urokinase plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM92292(uPa_17)
Affinity DataKi:  0.892nMAssay Description:Photometric_Method1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM92292(uPa_17)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/molepH: 7.4 T: 2°CAssay Description:Abbott uPA__Urokinase Human - Ki(uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16171(2-[4-chloro-7-({1-[(4-methylpiperazin-1-yl)carbony...)
Affinity DataKi:  1.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194745(diphenyl 1-[(N-2-thiophenesulfonyl-D-seryl)-L-alan...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16170(2-(4-chloro-7-{[1-(morpholin-4-ylcarbonyl)cyclopen...)
Affinity DataKi:  1.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414129(CHEMBL562412)
Affinity DataKi:  1.60nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147096(6-Carbamimidoyl-4-(pyrimidin-2-ylamino)-naphthalen...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards Urokinase-type plasminogen activator (urokinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147095(6-Carbamimidoyl-4-(5-ethanesulfonyl-furan-3-yl)-na...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards Urokinase-type plasminogen activator (urokinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14352(2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)
Affinity DataKi:  2.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50531924(CHEMBL4464577)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to mouse uPA by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14351(2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)
Affinity DataKi:  2.60nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16165(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  2.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194741(diphenyl 1-[(N-benzenesulfonyl-D-seryl)-L-alanyl]a...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088982(CHEMBL160253 | CHEMBL367004 | N-[1-(1-Carbamimidoy...)
Affinity DataIC50: 3.10nMAssay Description:The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228418(methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinopheny...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14354(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-(di...)
Affinity DataKi:  3.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228412(methyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4g...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228425(di-(4-acetamidophenyl) 1-(methylsulfonylamino)-2-(...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194743(diphenyl 1-[(N-alpha-toluenesulfonyl-D-seryl)-L-al...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194743(diphenyl 1-[(N-alpha-toluenesulfonyl-D-seryl)-L-al...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM92479(Tannic Acid, A | Tannic acid)
Affinity DataIC50: 4.10nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228420(di-(4-acetamidophenyl) 1-(benzyloxycarbonylamino)-...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034585(Peptide boronate | CHEMBL285285)
Affinity DataKi: >4.30nMAssay Description:Binding affinity against Urokinase plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145689([1-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-hydroxy-...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194737(diphenyl 1-[(N-o-methylbenzoyl-D-seryl)-L-alanyl]a...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50157087(6-(2-phenylcyclopropyl)-8-(pyrimidin-2-ylamino)-2-...)
Affinity DataKi:  5nMAssay Description:Binding affinity value against urokinase plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194746(diphenyl 1-[(N-o-methylbenzoyl-D-seryl)-L-alanyl]a...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194742(diphenyl 1-[(N-benzyl-D-seryl)-L-alanyl]amino-2-(4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50157087(6-(2-phenylcyclopropyl)-8-(pyrimidin-2-ylamino)-2-...)
Affinity DataKi:  5nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088978(N-[1-(1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarb...)
Affinity DataIC50: 5.10nMAssay Description:The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194734(diphenyl 1-[(N-p-methoxybenzenesulfonyl-D-seryl)-L...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194744(diphenyl 1-[(N-naphthalenesulfonyl-D-seryl)-L-alan...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16154(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  5.80nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194736(diphenyl 1-[(N-o,o-dimethylbenzoyl-D-seryl)-L-alan...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194735(diphenyl 1-[(N-p-cyanobenzenesulfonyl-D-seryl)-L-a...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50138673(6-carbamimidoyl-N-(4-ethyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50138673(6-carbamimidoyl-N-(4-ethyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to human urokinase-type plasminogen activator (microPa).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228421(diphenyl 1-(methylsulfonylamino)-2-(4-guanidinophe...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194738(diphenyl 1-[(N-p-bromobenzenesulfonyl-D-seryl)-L-a...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM92479(Tannic Acid, A | Tannic acid)
Affinity DataIC50: 6.60nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194732(di-(4-acetamidophenyl) 1-[(N-benzyloxycarbonyl-D-s...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50531924(CHEMBL4464577)
Affinity DataKi:  6.80nMAssay Description:Inhibition of mouse uPA preincubated for 15 mins followed by chromogenic substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194739(diphenyl 1-[(N-2-thienyl-D-seryl)-L-alanyl]amino-2...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228410(diphenyl 1-(benzyloxycarbonylamino)-2-(4-guanidino...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50194740(diphenyl 1-[(N-p-methylbenzoyl-D-seryl)-L-alanyl]a...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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