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TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038343(CHEMBL3360546)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of mouse serine racemase by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of mouse serine racemase by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10642(2-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  10nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132192(CHEMBL102871 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10635(3-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  30nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10635(3-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  100nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10634((2R)-1-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  200nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  450nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10633(3-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  800nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10638(3-{[6-(cyclopentylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  900nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10634((2R)-1-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
LigandPNGBDBM10639(3-[(6-amino-9-isopropyl-9H-purin-2-yl)amino]propan...)
Affinity DataIC50:  2.40E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10638(3-{[6-(cyclopentylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  2.40E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10633(3-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  2.50E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10641(6-(benzylamino)-9-isopropylpurine | CHEMBL85015 | ...)
Affinity DataIC50:  3.50E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10641(6-(benzylamino)-9-isopropylpurine | CHEMBL85015 | ...)
Affinity DataIC50:  4.50E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  4.60E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132199(3-{[8-Chloro-2-(1-hydroxymethyl-propylamino)-9-iso...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132196(2-(6-Benzylamino-9-isopropyl-8-methyl-9H-purin-2-y...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10636(2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  8.00E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10636(2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  9.40E+3nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10639(3-[(6-amino-9-isopropyl-9H-purin-2-yl)amino]propan...)
Affinity DataIC50:  1.00E+4nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132197(2-(6-Benzylamino-9-isopropyl-8-mercapto-9H-purin-2...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132193(2-[8-Chloro-6-(3-chloro-phenylamino)-9-isopropyl-9...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132198(CHEMBL103567 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132189(2-(6-Benzylamino-9-isopropyl-8-nitro-9H-purin-2-yl...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132190(2-(6-Benzylamino-8-chloro-9-isopropyl-9H-purin-2-y...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038343(CHEMBL3360546)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132195(6-Benzylamino-2-(1-hydroxymethyl-propylamino)-9-is...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataIC50:  6.70E+4nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132188(2-(8-Amino-6-benzylamino-9-isopropyl-9H-purin-2-yl...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038354(CHEBI:16513 | CHEMBL1794676)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132200(2-(6-Benzylamino-9-isopropyl-8-propoxy-9H-purin-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132194(2-[6-Benzylamino-8-(3-hydroxy-propylamino)-9-isopr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Palacky University

LigandPNGBDBM10640(3-{[6-(1-adamantylamino)-9-isopropyl-9H-purin-2-yl...)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10640(3-{[6-(1-adamantylamino)-9-isopropyl-9H-purin-2-yl...)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132191(2-(6-Benzylamino-8-bromo-9-isopropyl-9H-purin-2-yl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM92990(Aminomalonate)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038342(CHEMBL3360547)
Affinity DataIC50:  7.80E+5nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038341(CHEBI:30860 | METHYLMALONIC ACID)
Affinity DataIC50:  1.85E+6nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038340(CHEMBL3360548)
Affinity DataIC50:  2.16E+6nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038339(CHEMBL3360549)
Affinity DataIC50:  5.63E+6nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038338(CHEMBL3360550)
Affinity DataIC50:  7.03E+6nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mouse)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038355(CHEMBL3360551)
Affinity DataIC50:  4.06E+7nMAssay Description:Inhibition of mouse serine racemase using L-serine substrate by reversed-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed