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Found 178 with Last Name = 'gur' and Initial = 't'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101410((trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101411(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101413(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101412(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.400nMAssay Description:Inhibition constant of compound on ligand binding to aggregates of Amyloid beta was measured by comparing with [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100130(4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...)
Affinity DataKi:  0.900nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100130(4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...)
Affinity DataKi:  0.900nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100132(6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...)
Affinity DataKi:  1.60nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100132(6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...)
Affinity DataKi:  1.60nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100133(CHEMBL55401 | [4-(6-Bromo-benzothiazol-2-yl)-pheny...)
Affinity DataKi:  1.90nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100133(CHEMBL55401 | [4-(6-Bromo-benzothiazol-2-yl)-pheny...)
Affinity DataKi:  1.90nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100136(6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...)
Affinity DataKi:  5.40nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100136(6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...)
Affinity DataKi:  5.40nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi:  116nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi:  116nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition constant for amyloid beta compared to [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM26193(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)
Affinity DataKi: >1.80E+3nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100130(4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100133(CHEMBL55401 | [4-(6-Bromo-benzothiazol-2-yl)-pheny...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100133(CHEMBL55401 | [4-(6-Bromo-benzothiazol-2-yl)-pheny...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100130(4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant of compound on ligand binding to aggregates of Amyloid beta was measured by comparing with [125I]-TZDMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100132(6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100132(6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100136(6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100134(2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...)
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130714(1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-car...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from bovine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488058(N-(4-(4-(2- Methoxyethyl)piperazin- 1-yl)phenyl)-4...)
Affinity DataIC50:  1.30nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488080(N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4- yl)...)
Affinity DataIC50:  2.70nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488104(N-(4-(4-Amino-4- ethylpiperidin-1- yl)phenyl)-4-(1...)
Affinity DataIC50:  3nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488104(N-(4-(4-Amino-4- ethylpiperidin-1- yl)phenyl)-4-(1...)
Affinity DataIC50:  3.5nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM92330(Steroid, 10b)
Affinity DataIC50:  4.90nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50:  5.40nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488032(4-(1-Ethyl-3-(pyridin- 3-yl)-1H-pyrazol-4- yl)-N-(...)
Affinity DataIC50:  5.5nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488094(2-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50:  5.60nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488089(4-(1-(2,2- Difluoroethyl)-3- (pyridin-3-yl)-1H- py...)
Affinity DataIC50:  5.60nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488039(N-(4-(4- (Cyclopropylmethyl) piperazin-1-yl)phenyl...)
Affinity DataIC50:  5.70nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50:  6.10nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488038(N-(4-(4- Cyclopropylpiperazin- 1-yl)phenyl)-4-(1- ...)
Affinity DataIC50:  6.10nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488039(N-(4-(4- (Cyclopropylmethyl) piperazin-1-yl)phenyl...)
Affinity DataIC50:  6.10nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488079((4-((4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4- y...)
Affinity DataIC50:  6.30nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488032(4-(1-Ethyl-3-(pyridin- 3-yl)-1H-pyrazol-4- yl)-N-(...)
Affinity DataIC50:  6.60nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488054(2-Methyl-1-(4-(2-((2- methyl-1,2,3,4- tetrahydrois...)
Affinity DataIC50:  6.70nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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