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TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117772(CHEMBL10921 | N-(2-Diethylamino-ethyl)-2-[2-(4-flu...)
Affinity DataKi:  0.0300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237067(CHEMBL429125 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372562(CHEMBL255739)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237075(CHEMBL253317 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237065(2-(3-(aminomethyl)phenoxy)-N-(6-(3,5-dimethyl-1H-p...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237078(CHEMBL256123 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237083(CHEMBL256124 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237083(CHEMBL256124 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237078(CHEMBL256123 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237082(CHEMBL404863 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237064(CHEMBL401895 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237076(CHEMBL256331 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237084(CHEMBL403846 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237094(CHEMBL256332 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50232154(CHEMBL401321 | N-(2-(furan-2-yl)-6-(1H-pyrazol-1-y...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237065(2-(3-(aminomethyl)phenoxy)-N-(6-(3,5-dimethyl-1H-p...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237072(CHEMBL253528 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372561(CHEMBL255951)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237068(CHEMBL429850 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21174(CHEMBL398272 | N-[2-(furan-2-yl)-6-(1,3-thiazol-2-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21174(CHEMBL398272 | N-[2-(furan-2-yl)-6-(1,3-thiazol-2-...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372571(CHEMBL270654)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372576(CHEMBL402071)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372575(CHEMBL256382)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM128311(US8796284, 93)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 25°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237085(CHEMBL256547 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372574(CHEMBL403525)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372573(CHEMBL270655)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237088(CHEMBL256548 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237074(CHEMBL256755 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237095(CHEMBL256125 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237086(CHEMBL256327 | N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21195(N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfur...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50232156(CHEMBL252345 | N-(2-furan-2-yl-6-pyrazol-1-yl-pyri...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  1.60nMAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50237090(2-(3-cyanophenoxy)-N-(2-(pyridin-2-yl)-6-(thiazol-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50118337(1-(benzo[b]thiophen-3-yl)-3-(4-(3,4-dihydro-2H-ben...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21175(CHEMBL252171 | N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50176050(8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-1H-pu...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM241385 from rat recombinant adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372569(CHEMBL257670)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372570(CHEMBL404193)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Guinea pig)
UnitÉ

Curated by PDSP Ki Database
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50372563(CHEMBL402398)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21175(CHEMBL252171 | N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHrh3 protein(Rat)
UnitÉ

Curated by PDSP Ki Database
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21210(N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfur...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21211(N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfur...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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