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Found 163 with Last Name = 'vogt' and Initial = 'a'
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084504(CHEMBL3426991)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  7.30nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076135((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048961(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076130((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  55nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50472421(CHEMBL151777)
Affinity DataIC50:  87nMAssay Description:Competitive binding of 3[H]+isradipine to calcium channels of rat cardiac membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50076126((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048953(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  114nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048955((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076133((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  183nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50108076((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  203nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076131((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106505(6-Chloro-7-(indan-1-ylamino)-quinoline-5,8-dione |...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  303nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50366346(CHEMBL1790477)
Affinity DataIC50:  340nMAssay Description:In vitro inhibition of [3H]FPP incorporation into recombinant P21ras of NIH3T3 cells by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106491(5-Amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydro...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50283540((S)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-...)
Affinity DataIC50:  380nMAssay Description:In vitro inhibition of [3H]FPP incorporation into recombinant P21ras of NIH3T3 cells by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106503(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-phthalazi...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106493(7-[2-(4-Hydroxy-3-methoxy-phenyl)-ethylamino]-quin...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM80759(7-[(1-hydroxy-1-phenylpropan-2-yl)amino]quinoline-...)
Affinity DataIC50:  510nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048952(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2...)
Affinity DataIC50:  543nMAssay Description:Inhibition of pig brain farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106498(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-isoquinol...)
Affinity DataIC50:  590nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084499(CHEMBL3426986)
Affinity DataIC50:  640nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106508(7-[2-(3,5-Dibromo-4-hydroxy-phenyl)-ethylamino]-qu...)
Affinity DataIC50:  640nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106495(6-(2-Hydroxy-1-methyl-2-phenyl-ethylamino)-quinoli...)
Affinity DataIC50:  670nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048956((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)
Affinity DataIC50:  710nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084468(CHEMBL1715541)
Affinity DataIC50:  770nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084477(CHEMBL3426981)
Affinity DataIC50:  770nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106494(7-Chloro-6-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataIC50:  820nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084470(CHEMBL1522941)
Affinity DataIC50:  830nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084476(CHEMBL3426980)
Affinity DataIC50:  850nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076133((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)
Affinity DataIC50:  900nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106506(6-Chloro-7-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperaz...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048960(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)
Affinity DataIC50:  917nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106502(6-Chloro-7-(4-hexyloxy-phenylamino)-quinoline-5,8-...)
Affinity DataIC50:  930nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048954((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)
Affinity DataIC50:  1.07E+3nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106503(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-phthalazi...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory Activity against Recombinant Human VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084505(CHEMBL1453503)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084473(CHEMBL3426978)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076126((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106500(6,7-Dichloro-isoquinoline-5,8-dione | CHEMBL335110)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084478(CHEMBL3426982)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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