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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 55 hits in this display   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  12.3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  24.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  114nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  234nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  353nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  736nMMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  2.14E+3nMMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  2.46E+3nMAssay Description:Inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  2.46E+3nMAssay Description:Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  4.84E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  6.40E+3nMAssay Description:Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  6.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  8.32E+3nMAssay Description:Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Nih

Curated by PDSP Ki Database
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  2.45E+4nMAssay Description:Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  8.01E+4nMAssay Description:Displacement of [3H]DTBZ from VMAT2 in rat whole brain by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  1.01E+5nMAssay Description:Displacement of [125I]DOI from human 5HT2A receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  2.70E+5nMAssay Description:Competitive inhibition of Rat liver Monoamine Oxidase B at 37 degree C (pH= 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataKi:  3.46E+5nMAssay Description:Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Bos taurus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataKi:  5.50E+5nMAssay Description:Inhibitory activity against Monoamine Oxidase B of Bovine liver in competitive inhibition assay at 25 degree C (pH=7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataKi:  5.50E+5nMAssay Description:Competitive inhibition of Rat liver Monoamine Oxidase B at 37 degree C (pH= 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Bos taurus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataKi:  8.00E+5nMAssay Description:Inhibitory activity against Monoamine Oxidase B of Bovine liver in competitive inhibition assay at 25 degree C (pH=7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Mus musculus)
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataIC50:  2.74E+3nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50009057((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Affinity DataIC50:  3.62E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 3(Rattus norvegicus)
Medical College Of Georgia

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataIC50:  2.48E+5nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  2.04E+3nMAssay Description:Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  843nMAssay Description:Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  126nMAssay Description:Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  330nMAssay Description:Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  1.82E+3nMAssay Description:Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  133nMAssay Description:Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  233nMAssay Description:Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  279nMAssay Description:Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  18nMAssay Description:Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  202nMAssay Description:Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  1.11E+3nMAssay Description:Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  70nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  2.44E+3nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  920nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  1.60E+3nMAssay Description:Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  890nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Macaca mulatta)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  2.50E+3nMAssay Description:Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Macaca mulatta)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  5.30E+3nMAssay Description:Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate readerMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  3.30E+3nMAssay Description:Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499((S)Methamphetamine | METHAMPHETAMINE)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359500((R)Methamphetamine | CHEMBL1927030)
Affinity DataEC50:  1.19E+3nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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