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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
55
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 12.3nM
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 24.5nM
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 48nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: 114nM
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 234nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 353nM
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: 600nM
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: 736nM
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3D Structure (crystal)
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: 2.14E+3nM
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3D Structure (crystal)
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 2.46E+3nM
Assay Description:
Inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles by liquid scintillation spectrometry
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 2.46E+3nM
Assay Description:
Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopy
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.84E+3nM
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 6.40E+3nM
Assay Description:
Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 6.70E+3nM
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 8.32E+3nM
Assay Description:
Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligand
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
Ki: 2.45E+4nM
Assay Description:
Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 8.01E+4nM
Assay Description:
Displacement of [3H]DTBZ from VMAT2 in rat whole brain by liquid scintillation spectrometry
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 1.01E+5nM
Assay Description:
Displacement of [125I]DOI from human 5HT2A receptor expressed in HEK293 cell membranes
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Target
Amine oxidase [flavin-containing] B
(Rattus norvegicus (rat))
Syntex Research
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 2.70E+5nM
Assay Description:
Competitive inhibition of Rat liver Monoamine Oxidase B at 37 degree C (pH= 7.4)
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
Ki: 3.46E+5nM
Assay Description:
Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting method
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Target
Amine oxidase [flavin-containing] B
(Bos taurus)
Syntex Research
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
Ki: 5.50E+5nM
Assay Description:
Inhibitory activity against Monoamine Oxidase B of Bovine liver in competitive inhibition assay at 25 degree C (pH=7.4)
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Target
Amine oxidase [flavin-containing] B
(Rattus norvegicus (rat))
Syntex Research
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
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Affinity Data
Ki: 5.50E+5nM
Assay Description:
Competitive inhibition of Rat liver Monoamine Oxidase B at 37 degree C (pH= 7.4)
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Target
Amine oxidase [flavin-containing] B
(Bos taurus)
Syntex Research
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
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Affinity Data
Ki: 8.00E+5nM
Assay Description:
Inhibitory activity against Monoamine Oxidase B of Bovine liver in competitive inhibition assay at 25 degree C (pH=7.4)
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Target
Synaptic vesicular amine transporter
(Mus musculus)
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
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Affinity Data
IC50: 2.74E+3nM
Assay Description:
Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50009057
((R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAM...)
Copy SMILES
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Affinity Data
IC50: 3.62E+3nM
Assay Description:
Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...
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Target
Solute carrier family 22 member 3
(Rattus norvegicus)
Medical College Of Georgia
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
IC50: 2.48E+5nM
Assay Description:
TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cells
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
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Affinity Data
EC50: 2.04E+3nM
Assay Description:
Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
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Affinity Data
EC50: 843nM
Assay Description:
Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 126nM
Assay Description:
Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...
More data for this Ligand-Target Pair
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
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Affinity Data
EC50: 330nM
Assay Description:
Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...
More data for this Ligand-Target Pair
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.82E+3nM
Assay Description:
Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 133nM
Assay Description:
Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 233nM
Assay Description:
Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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CHEMBL
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 279nM
Assay Description:
Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 18nM
Assay Description:
Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 202nM
Assay Description:
Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.11E+3nM
Assay Description:
Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...
More data for this Ligand-Target Pair
Target Info
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
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Affinity Data
EC50: 1.30E+3nM
Assay Description:
Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay
More data for this Ligand-Target Pair
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 70nM
Assay Description:
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins
More data for this Ligand-Target Pair
Target Info
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KEGG
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2.44E+3nM
Assay Description:
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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CHEMBL
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 920nM
Assay Description:
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Ligand Info
Purchase
ChEBI
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.60E+3nM
Assay Description:
Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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CHEMBL
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 890nM
Assay Description:
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Trace amine-associated receptor 1
(Macaca mulatta)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
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Affinity Data
EC50: 2.50E+3nM
Assay Description:
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Trace amine-associated receptor 1
(Macaca mulatta)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 5.30E+3nM
Assay Description:
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
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Affinity Data
EC50: 3.30E+3nM
Assay Description:
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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antibodypedia
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CHEMBL
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Copy BDB DOI
Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50359499
((S)Methamphetamine | METHAMPHETAMINE)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.50E+3nM
Assay Description:
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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KEGG
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In Depth
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PubMed
DrugBank
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3D Structure (crystal)
Copy BDB DOI
Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by
ChEMBL
Ligand
BDBM50359500
((R)Methamphetamine | CHEMBL1927030)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.19E+3nM
Assay Description:
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
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