Target (4)
Compound (14)
Article Title (2)
Article Author (350)
Assay (6)
asparaginyl endopeptidase (ae) hiv-1 protease ae pretherapy isolated ae protease mutant (v82f) hiv-1 protease ae-p (v3i, l10i, i13v, l33i, e35d, m36i, s37n, r41k, i54v, l63h, h69k, v82f, l89m)
Inoue, Y; Omodani, T; Shiratake, R; Okazaki, H; Kuromiya, A; Kubo, T; Sato, F Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem 17: 7477 -86 (2009) Björklund, C; Adolfsson, H; Jansson, K; Lindberg, J; Vrang, L; Hallberg, A; Rosenquist, S; Samuelsson, B Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bioorg Med Chem 18: 1711 -23 (2010)
Ibrahim, MK; Eissa, IH; Abdallah, AE; Metwaly, AM; Radwan, MM; ElSohly, MA Bioorg Med Chem 25: 1496 -1513 (2017) Adang, AE; Lucas, H; de Man, AP; Engh, RA; Grootenhuis, PD Bioorg Med Chem Lett 8: 3603 -8 (1999) Katayama, S; Ae, N; Kodo, T; Masumoto, S; Hourai, S; Tamamura, C; Tanaka, H; Nagata, R J Med Chem 46: 691 -701 (2003) Ahmed, AE; Hanna, PE; Grund, VR J Med Chem 19: 117 -22 (1976) Fisher, MJ; Arfstan, AE; Giese, U; Gunn, BP; Harms, CS; Khau, V; Kinnick, MD; Lindstrom, TD; Martinelli, MJ; Mest, HJ; Mohr, M; Morin, JM; Mullaney, JT; Nunes, A; Paal, M; Rapp, A; Rühter, G; Ruterbories, KJ; Sall, DJ; Scarborough, RM; Schotten, T; Sommer, B; Stenzel, W; Towner, RD; Um, SL J Med Chem 42: 4875 -89 (1999) Zhang, P; Huang, W; Wang, L; Bao, L; Jia, ZJ; Bauer, SM; Goldman, EA; Probst, GD; Song, Y; Su, T; Fan, J; Wu, Y; Li, W; Woolfrey, J; Sinha, U; Wong, PW; Edwards, ST; Arfsten, AE; Clizbe, LA; Kanter, J; Pandey, A; Park, G; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Bioorg Med Chem Lett 19: 2179 -85 (2009) Gubiani, JR; Wijeratne, EM; Shi, T; Araujo, AR; Arnold, AE; Chapman, E; Gunatilaka, AA Bioorg Med Chem 25: 1860 -1866 (2017) Alafeefy, AM; Isik, S; Abdel-Aziz, HA; Ashour, AE; Vullo, D; Al-Jaber, NA; Supuran, CT Bioorg Med Chem 21: 1396 -403 (2013) Gopalsamy, A; Aulabaugh, AE; Barakat, A; Beaumont, KC; Cabral, S; Canterbury, DP; Casimiro-Garcia, A; Chang, JS; Chen, MZ; Choi, C; Dow, RL; Fadeyi, OO; Feng, X; France, SP; Howard, RM; Janz, JM; Jasti, J; Jasuja, R; Jones, LH; King-Ahmad, A; Knee, KM; Kohrt, JT; Limberakis, C; Liras, S; Martinez, CA; McClure, KF; Narayanan, A; Narula, J; Novak, JJ; O'Connell, TN; Parikh, MD; Piotrowski, DW; Plotnikova, O; Robinson, RP; Sahasrabudhe, PV; Sharma, R; Thuma, BA; Vasa, D; Wei, L; Wenzel, AZ; Withka, JM; Xiao, J; Yayla, HG J Med Chem 64: 326 -342 (2021) Bilodeau, MT; Balitza, AE; Koester, TJ; Manley, PJ; Rodman, LD; Buser-Doepner, C; Coll, KE; Fernandes, C; Gibbs, JB; Heimbrook, DC; Huckle, WR; Kohl, N; Lynch, JJ; Mao, X; McFall, RC; McLoughlin, D; Miller-Stein, CM; Rickert, KW; Sepp-Lorenzino, L; Shipman, JM; Subramanian, R; Thomas, KA; Wong, BK; Yu, S; Hartman, GD J Med Chem 47: 6363 -72 (2004) Bergquist, BL; Jefferson, KG; Kintz, HN; Barber, AE; Yeagley, AA ACS Med Chem Lett 9: 51 -55 (2018) Pribut, N; Basson, AE; van Otterlo, WAL; Liotta, DC; Pelly, SC ACS Med Chem Lett 10: 196 -202 (2019) Rogers, JP; Beuscher, AE; Flajolet, M; McAvoy, T; Nairn, AC; Olson, AJ; Greengard, P J Med Chem 49: 1658 -67 (2006) Van Dort, ME; Hong, H; Wang, H; Nino, CA; Lombardi, RL; Blanks, AE; Galbán, S; Ross, BD J Med Chem 59: 2512 -22 (2016) Li, J; Bronk, BS; Dirlam, JP; Blize, AE; Bertinato, P; Jaynes, BH; Hickman, A; Miskell, C; Pillai, UA; Tibbitts, JS; Haven, ML; Kolosko, NL; Barry, CJ; Manion, TB Bioorg Med Chem Lett 17: 1996 -9 (2007) Geurink, PP; van der Linden, WA; Mirabella, AC; Gallastegui, N; de Bruin, G; Blom, AE; Voges, MJ; Mock, ED; Florea, BI; van der Marel, GA; Driessen, C; van der Stelt, M; Groll, M; Overkleeft, HS; Kisselev, AF J Med Chem 56: 1262 -75 (2013) Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; von der Saal, W; Limberg, A; Georges, G; Engh, RA; Goller, B; Rueger, P; Rueth, M J Med Chem 54: 312 -9 (2011) Tamura, SY; Weinhouse, MI; Roberts, CA; Goldman, EA; Masukawa, K; Anderson, SM; Cohen, CR; Bradbury, AE; Bernardino, VT; Dixon, SA; Ma, MG; Nolan, TG; Brunck, TK Bioorg Med Chem Lett 10: 983 -7 (2000) Shirey, JK; Xiang, Z; Orton, D; Brady, AE; Johnson, KA; Williams, R; Ayala, JE; Rodriguez, AL; Wess, J; Weaver, D; Niswender, CM; Conn, PJ Nat Chem Biol 4: 42 -50 (2007) Reggio, PH; Wang, T; Brown, AE; Fleming, DN; Seltzman, HH; Griffin, G; Pertwee, RG; Compton, DR; Abood, ME; Martin, BR J Med Chem 40: 3312 -8 (1997) Naiman, N; Lyon, RA; Bullock, AE; Rydelek, LT; Titeler, M; Glennon, RA J Med Chem 32: 253 -6 (1989) Busch, AE; Karbach, U; Miska, D; Gorboulev, V; Akhoundova, A; Volk, C; Arndt, P; Ulzheimer, JC; Sonders, MS; Baumann, C; Waldegger, S; Lang, F; Koepsell, H Mol Pharmacol 54: 342 -52 (1998) Downs, RP; Xiao, Z; Ikedionwu, MO; Cleveland, JW; Lin Chin, A; Cafferty, AE; Darryl Quarles, L; Carrick, JD Bioorg Med Chem 29: (2021) Neves, BJ; Dantas, RF; Senger, MR; Melo-Filho, CC; Valente, WC; de Almeida, AC; Rezende-Neto, JM; Lima, EF; Paveley, R; Furnham, N; Muratov, E; Kamentsky, L; Carpenter, AE; Braga, RC; Silva-Junior, FP; Andrade, CH J Med Chem 59: 7075 -88 (2016) Grunewald, GL; Carter, AE; Sall, DJ; Monn, JA J Med Chem 31: 60 -5 (1988) Kim, M; Wei, JD; Harmalkar, DS; Goo, JI; Lee, K; Choi, Y; Kim, JH; Cho, AE ACS Med Chem Lett 11: 1529 -1534 (2020) Rouse, MB; Seefeld, MA; Leber, JD; McNulty, KC; Sun, L; Miller, WH; Zhang, S; Minthorn, EA; Concha, NO; Choudhry, AE; Schaber, MD; Heerding, DA Bioorg Med Chem Lett 19: 1508 -11 (2009) Langham, JJ; Cleves, AE; Spitzer, R; Kirshner, D; Jain, AN J Med Chem 52: 6107 -25 (2009) Hansen, MR; Jakobsen, TH; Bang, CG; Cohrt, AE; Hansen, CL; Clausen, JW; Le Quement, ST; Tolker-Nielsen, T; Givskov, M; Nielsen, TE Bioorg Med Chem 23: 1638 -50 (2015) Weber, AE; Steiner, MG; Krieter, PA; Colletti, AE; Tata, JR; Halgren, TA; Ball, RG; Doyle, JJ; Schorn, TW; Stearns, RA J Med Chem 35: 3755 -73 (1992) Lowe, JD; Sanderson, HS; Cooke, AE; Ostovar, M; Tsisanova, E; Withey, SL; Chavkin, C; Husbands, SM; Kelly, E; Henderson, G; Bailey, CP Mol Pharmacol 88: 347 -56 Cumming, JG; Brown, SJ; Cooper, AE; Faull, AW; Flynn, AP; Grime, K; Oldfield, J; Shaw, JS; Shepherd, E; Tucker, H; Whittaker, D Bioorg Med Chem Lett 16: 3533 -6 (2006) Belliotti, TR; Wustrow, DJ; Brink, WA; Zoski, KT; Shih, YH; Whetzel, SZ; Georgic, LM; Corbin, AE; Akunne, HC; Heffner, TG; Pugsley, TA; Wise, LD J Med Chem 42: 5181 -7 (2000) Durcik, M; Cotman, AE; Toplak, Ž; Možina, Š; Skok, Ž; Szili, PE; Czikkely, M; Maharramov, E; Vu, TH; Piras, MV; Zidar, N; Ilaš, J; Zega, A; Trontelj, J; Pardo, LA; Hughes, D; Huseby, D; Berruga-Fernández, T; Cao, S; Simoff, I; Svensson, R; Korol, SV; Jin, Z; Vicente, F; Ramos, MC; Mundy, JEA; Maxwell, A; Stevenson, CEM; Lawson, DM; Glinghammar, B; Sjöström, E; Bohlin, M; Oreskär, J; Alvér, S; Janssen, GV; Sterk, GJ; Kikelj, D; Pal, C; Tomašič, T; Peterlin Mašič, L J Med Chem 66: 3968 -3994 (2023) D., AE; W., AS; Jean, BC; R., CK; C., IT; KOLAKOWSKI, KG; Manoj, K; A., ME; L., MM; Alexander, MJ; Tiphaine, M; J., MM; Dino, PT; Alexander, PM; Marta, P WIPO WO2022098970 (2022) Huang, W; Ojo, KK; Zhang, Z; Rivas, K; Vidadala, RS; Scheele, S; DeRocher, AE; Choi, R; Hulverson, MA; Barrett, LK; Bruzual, I; Siddaramaiah, LK; Kerchner, KM; Kurnick, MD; Freiberg, GM; Kempf, D; Hol, WG; Merritt, EA; Neckermann, G; de Hostos, EL; Isoherranen, N; Maly, DJ; Parsons, M; Doggett, JS; Van Voorhis, WC; Fan, E ACS Med Chem Lett 6: 1184 -1189 (2015) Machonkin, TE; Doerner, AE Biochemistry 50: 8899 -913 (2011) Leeson, PD; Williams, BJ; Rowley, M; Moore, KW; Baker, R; Kemp, JA; Priestley, T; Foster, AC; Donald, AE Bioorg Med Chem Lett 3: 71 -76 (1993) Hart, AC; Abell, L; Guo, J; Mertzman, ME; Padmanabha, R; Macor, JE; Chaudhry, C; Lu, H; O'Malley, K; Shaw, PJ; Weigelt, C; Pokross, M; Kish, K; Kim, KS; Cornelius, L; Douglas, AE; Calambur, D; Zhang, P; Carpenter, B; Pitts, WJ ACS Med Chem Lett 11: 266 -271 (2020) Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA ACS Med Chem Lett 6: 655 -9 (2015) McDonnell, ME; Zhang, SP; Nasser, N; Dubin, AE; Dax, SL Bioorg Med Chem Lett 14: 531 -4 (2003) Xiao, J; Free, RB; Barnaeva, E; Conroy, JL; Doyle, T; Miller, B; Bryant-Genevier, M; Taylor, MK; Hu, X; Dulcey, AE; Southall, N; Ferrer, M; Titus, S; Zheng, W; Sibley, DR; Marugan, JJ J Med Chem 57: 3450 -63 (2014) Sherer, BA; Hull, K; Green, O; Basarab, G; Hauck, S; Hill, P; Loch, JT; Mullen, G; Bist, S; Bryant, J; Boriack-Sjodin, A; Read, J; DeGrace, N; Uria-Nickelsen, M; Illingworth, RN; Eakin, AE Bioorg Med Chem Lett 21: 7416 -20 (2011) King, D; Iwuagwu, C; Cook, J; McDonald, IM; Mate, R; Zusi, FC; Hill, MD; Fang, H; Zhao, R; Wang, B; Easton, AE; Miller, R; Post-Munson, D; Knox, RJ; Gallagher, L; Westphal, R; Molski, T; Fan, J; Clarke, W; Benitex, Y; Lentz, KA; Denton, R; Morgan, D; Zaczek, R; Lodge, NJ; Bristow, LJ; Macor, JE; Olson, RE ACS Med Chem Lett 8: 366 -371 (2017) Lampa, A; Alogheli, H; Ehrenberg, AE; Åkerblom, E; Svensson, R; Artursson, P; Danielson, UH; Karlén, A; Sandström, A Bioorg Med Chem 22: 6595 -615 (2015) Elsawi, AE; Elbadawi, MM; Nocentini, A; Almahli, H; Giovannuzzi, S; Shaldam, M; Salem, R; Ibrahim, TM; Abdel-Aziz, HA; Supuran, CT; Eldehna, WM J Med Chem 66: 10558 -10578 (2023) Evren, AE; Nuha, D; Dawbaa, S; Sağlık, BN; Yurttaş, L Eur J Med Chem 229: (2022) Ibrahim, NM; Fahim, SH; Hassan, M; Farag, AE; Georgey, HH Eur J Med Chem 228: (2022) Fenwick, AE; Garnier, B; Gribble, AD; Ife, RJ; Rawlings, AD; Witherington, J Bioorg Med Chem Lett 11: 195 -8 (2001) Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS US Patent US9745328 (2017) Showell, GA; Bourrain, S; Fletcher, SR; Neduvelil, JG; Fletcher, AE; Freedman, SB; Patel, S; Smith, AJ; Marshall, GR; Graham, MI; Sohal, B; Matassa, VG Bioorg Med Chem Lett 5: 3023 -3026 (1995) Wang, Z; Zhang, Y; Pinkas, DM; Fox, AE; Luo, J; Huang, H; Cui, S; Xiang, Q; Xu, T; Xun, Q; Zhu, D; Tu, Z; Ren, X; Brekken, RA; Bullock, AN; Liang, G; Ding, K; Lu, X J Med Chem 61: 7977 -7990 (2018) Balsera, B; Mulet, J; Fernández-Carvajal, A; de la Torre-Martínez, R; Ferrer-Montiel, A; Hernández-Jiménez, JG; Estévez-Herrera, J; Borges, R; Freitas, AE; López, MG; García-López, MT; González-Muñiz, R; Pérez de Vega, MJ; Valor, LM; Svobodová, L; Sala, S; Sala, F; Criado, M Eur J Med Chem 86: 724 -39 (2014) Katz, JD; Jewell, JP; Guerin, DJ; Lim, J; Dinsmore, CJ; Deshmukh, SV; Pan, BS; Marshall, CG; Lu, W; Altman, MD; Dahlberg, WK; Davis, L; Falcone, D; Gabarda, AE; Hang, G; Hatch, H; Holmes, R; Kunii, K; Lumb, KJ; Lutterbach, B; Mathvink, R; Nazef, N; Patel, SB; Qu, X; Reilly, JF; Rickert, KW; Rosenstein, C; Soisson, SM; Spencer, KB; Szewczak, AA; Walker, D; Wang, W; Young, J; Zeng, Q J Med Chem 54: 4092 -108 (2011) Schwehm, C; Kellam, B; Garces, AE; Hill, SJ; Kindon, ND; Bradshaw, TD; Li, J; Macdonald, SJ; Rowedder, JE; Stoddart, LA; Stocks, MJ J Med Chem 60: 1534 -1554 (2017) Forbes, IT; Douglas, S; Gribble, AD; Ife, RJ; Lightfoot, AP; Garner, AE; Riley, GJ; Jeffrey, P; Stevens, AJ; Stean, TO; Thomas, DR Bioorg Med Chem Lett 12: 3341 -4 (2002) Shtyrlin, NV; Kayumov, AR; Agafonova, MN; Garipov, MR; Gatina, AE; Pugachev, MV; Bulatova, ES; Grishaev, DY; Iksanova, AG; Khaziev, RM; Ganiev, IM; Aimaletdinov, AM; Gnezdilov, OI; Shtyrlin, YG Eur J Med Chem 261: Smith, EW; Nevins, AM; Qiao, Z; Liu, Y; Getschman, AE; Vankayala, SL; Kemp, MT; Peterson, FC; Li, R; Volkman, BF; Chen, Y J Med Chem 59: 4342 -51 (2016) Ghonim, AE; Ligresti, A; Rabbito, A; Mahmoud, AM; Di Marzo, V; Osman, NA; Abadi, AH Eur J Med Chem 180: 154 -170 (2019) Mesguiche, V; Parsons, RJ; Arris, CE; Bentley, J; Boyle, FT; Curtin, NJ; Davies, TG; Endicott, JA; Gibson, AE; Golding, BT; Griffin, RJ; Jewsbury, P; Johnson, LN; Newell, DR; Noble, ME; Wang, LZ; Hardcastle, IR Bioorg Med Chem Lett 13: 217 -22 (2003) Madariaga-Mazón, A; González-Andrade, M; González, Mdel C; Glenn, AE; Cerda-García-Rojas, CM; Mata, R J Nat Prod 76: 1454 -60 (2013) Stefanowicz, J; Słowiński, T; Wróbel, MZ; Herold, F; Gomółka, AE; Wesołowska, A; Jastrzębska-Więsek, M; Partyka, A; Andres-Mach, M; Czuczwar, SJ; Łuszczki, JJ; Zagaja, M; Siwek, A; Nowak, G; Żołnierek, M; Bączek, T; Ulenberg, S; Belka, M; Turło, J Bioorg Med Chem 24: 3994 -4007 (2016) de Souza, MM; Andreolla, MC; Ribeiro, TC; Gonçalves, AE; Medeiros, AR; de Souza, AS; Ferreira, LLG; Andricopulo, AD; Yunes, RA; de Oliveira, AS RSC Med Chem 11: 307 -316 (2020) Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L US Patent US10865208 (2020) Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Buson, A; Greco, AE US Patent US12178791 (2024) Sivendran, S; Jones, V; Sun, D; Wang, Y; Grzegorzewicz, AE; Scherman, MS; Napper, AD; McCammon, JA; Lee, RE; Diamond, SL; McNeil, M Bioorg Med Chem 18: 896 -908 (2010) Magee, TV; Ripp, SL; Li, B; Buzon, RA; Chupak, L; Dougherty, TJ; Finegan, SM; Girard, D; Hagen, AE; Falcone, MJ; Farley, KA; Granskog, K; Hardink, JR; Huband, MD; Kamicker, BJ; Kaneko, T; Knickerbocker, MJ; Liras, JL; Marra, A; Medina, I; Nguyen, TT; Noe, MC; Obach, RS; O'Donnell, JP; Penzien, JB; Reilly, UD; Schafer, JR; Shen, Y; Stone, GG; Strelevitz, TJ; Sun, J; Tait-Kamradt, A; Vaz, AD; Whipple, DA; Widlicka, DW; Wishka, DG; Wolkowski, JP; Flanagan, ME J Med Chem 52: 7446 -57 (2009) Wang, JL; Aston, K; Limburg, D; Ludwig, C; Hallinan, AE; Koszyk, F; Hamper, B; Brown, D; Graneto, M; Talley, J; Maziasz, T; Masferrer, J; Carter, J Bioorg Med Chem Lett 20: 7164 -8 (2010) Huckvale, R; Harnden, AC; Cheung, KJ; Pierrat, OA; Talbot, R; Box, GM; Henley, AT; de Haven Brandon, AK; Hallsworth, AE; Bright, MD; Akpinar, HA; Miller, DSJ; Tarantino, D; Gowan, S; Hayes, A; Gunnell, EA; Brennan, A; Davis, OA; Johnson, LD; de Klerk, S; McAndrew, C; Le Bihan, YV; Meniconi, M; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Bellenie, BR; Hoelder, S J Med Chem 65: 8191 -8207 (2022) Pechulis, AD; Beck, JP; Curry, MA; Wolf, MA; Harms, AE; Xi, N; Opalka, C; Sweet, MP; Yang, Z; Vellekoop, AS; Klos, AM; Crocker, PJ; Hassler, C; Laws, M; Kitchen, DB; Smith, MA; Olson, RE; Liu, S; Molino, BF Bioorg Med Chem Lett 22: 7219 -22 (2012) Villalta-Romero, F; Gortat, A; Herrera, AE; Arguedas, R; Quesada, J; de Melo, RL; Calvete, JJ; Montero, M; Murillo, R; Rucavado, A; Gutiérrez, JM; Pérez-Payá, E ACS Med Chem Lett 3: 540 -543 (2012) Poutiainen, PK; Palvimo, JJ; Hinkkanen, AE; Valkonen, A; Väisänen, TK; Laatikainen, R; Pulkkinen, JT J Med Chem 56: 1064 -73 (2013) Schnute, ME; Wennerstål, M; Alley, J; Bengtsson, M; Blinn, JR; Bolten, CW; Braden, T; Bonn, T; Carlsson, B; Caspers, N; Chen, M; Choi, C; Collis, LP; Crouse, K; Färnegårdh, M; Fennell, KF; Fish, S; Flick, AC; Goos-Nilsson, A; Gullberg, H; Harris, PK; Heasley, SE; Hegen, M; Hromockyj, AE; Hu, X; Husman, B; Janosik, T; Jones, P; Kaila, N; Kallin, E; Kauppi, B; Kiefer, JR; Knafels, J; Koehler, K; Kruger, L; Kurumbail, RG; Kyne, RE; Li, W; Löfstedt, J; Long, SA; Menard, CA; Mente, S; Messing, D; Meyers, MJ; Napierata, L; Nöteberg, D; Nuhant, P; Pelc, MJ; Prinsen, MJ; Rhönnstad, P; Backström-Rydin, E; Sandberg, J; Sandström, M; Shah, F; Sjöberg, M; Sundell, A; Taylor, AP; Thorarensen, A; Trujillo, JI; Trzupek, JD; Unwalla, R; Vajdos, FF; Weinberg, RA; Wood, DC; Xing, L; Zamaratski, E; Zapf, CW; Zhao, Y; Wilhelmsson, A; Berstein, G J Med Chem 61: 10415 -10439 (2018) Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H US Patent US10988451 (2021) Glennon, RA; Ismaiel, AE; McCarthy, BG; Peroutka, SJ Eur J Pharmacol 168: 387 -92 (1989) Coop, A; Jacobson, AE Bioorg Med Chem Lett 9: 357 -62 (1999) Kwiatkowski, J; Liu, B; Pang, S; Ahmad, NHB; Wang, G; Poulsen, A; Yang, H; Poh, YR; Tee, DHY; Ong, E; Retna, P; Dinie, N; Kwek, P; Wee, JLK; Manoharan, V; Low, CB; Seah, PG; Pendharkar, V; Sangthongpitag, K; Joy, J; Baburajendran, N; Jansson, AE; Nacro, K; Hill, J; Keller, TH; Hung, AW J Med Chem 63: 621 -637 (2020) Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, L; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT ACS Med Chem Lett 11: 56 -64 (2020) Swahn, BM; Wensbo, D; Sandell, J; Sohn, D; Slivo, C; Pyring, D; Malmström, J; Arzel, E; Vallin, M; Bergh, M; Jeppsson, F; Johnson, AE; Juréus, A; Neelissen, J; Svensson, S Bioorg Med Chem Lett 20: 1976 -80 (2010) Procopiou, PA; Barrett, VJ; Biggadike, K; Butchers, PR; Craven, A; Ford, AJ; Guntrip, SB; Holmes, DS; Hughes, SC; Jones, AE; Looker, BE; Mutch, PJ; Ruston, M; Needham, D; Smith, CE J Med Chem 57: 159 -70 (2014) Godínez, LA; Patel, S; Criss, CM; Kaifer, AE J Phys Chem 99: 17449 -55 (1995) Ahmed, EM; Kassab, AE; El-Malah, AA; Hassan, MSA Eur J Med Chem 171: 25 -37 (2019) Collado, I; Pedregal, C; Bueno, AB; Marcos, A; González, R; Blanco-Urgoiti, J; Pérez-Castells, J; Schoepp, DD; Wright, RA; Johnson, BG; Kingston, AE; Moher, ED; Hoard, DW; Griffey, KI; Tizzano, JP J Med Chem 47: 456 -66 (2004) Machrouhi, F; Ouhamou, N; Laderoute, K; Calaoagan, J; Bukhtiyarova, M; Ehrlich, PJ; Klon, AE Bioorg Med Chem Lett 20: 6394 -9 (2010) Seitzberg, JG; Knapp, AE; Lund, BW; Mandrup Bertozzi, S; Currier, EA; Ma, JN; Sherbukhin, V; Burstein, ES; Olsson, R J Med Chem 51: 5490 -3 (2008) Ispikoudi, M; Amvrazis, M; Kontogiorgis, C; Koumbis, AE; Litinas, KE; Hadjipavlou-Litina, D; Fylaktakidou, KC Eur J Med Chem 45: 5635 -45 (2010) Chilmonczyk, Z; Les, A; Wozniakowska, A; Cybulski, J; Koziol, AE; Gdaniec, M J Med Chem 38: 1701 -10 (1995) Ślifirski, G; Król, M; Kleps, J; Ulenberg, S; Belka, M; Bączek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozioł, AE; Turło, J; Herold, F Eur J Med Chem 166: 144 -158 (2019) Ledneczki, I; Tapolcsányi, P; Gábor, E; Visegrády, A; Vass, M; Éles, J; Holm, P; Horváth, A; Pocsai, A; Mahó, S; Greiner, I; Krámos, B; Béni, Z; Kóti, J; Káncz, AE; Thán, M; Kolok, S; Laszy, J; Balázs, O; Bugovits, G; Nagy, J; Vastag, M; Szájli, Á; Bozó, É; Lévay, G; Lendvai, B; Némethy, Z Eur J Med Chem 214: (2021) Ferreira, FB; Pereira, TM; Souza, DLN; Lopes, DS; Freitas, V; Ávila, VMR; Kümmerle, AE; Sant'Anna, CMR ACS Med Chem Lett 8: 1136 -1141 (2017) Zähringer, S; Rumpf, T; Melesina, J; Lang, AE; Aktories, K; Sippl, W; Jung, M; Wagner, GK Bioorg Med Chem 68: (2022) Solbak, SMØ; Zang, J; Narayanan, D; Høj, LJ; Bucciarelli, S; Softley, C; Meier, S; Langkilde, AE; Gotfredsen, CH; Sattler, M; Bach, A J Med Chem 63: 1156 -1177 (2020) Levinson, AM; Houang, E; Igawa, H; Hirst, KL; Kim, B; Leffler, AE; Palomero-Vazquez, MA; Therrien, E; Huang, X; Watts, KS; Albanese, S; Gordon, JA; Placzek, A US Patent US20240279221 (2024) Boger, DL; Sato, H; Lerner, AE; Austin, BJ; Patterson, JE; Patricelli, MP; Cravatt, BF Bioorg Med Chem Lett 9: 265 -70 (1999) Ekblad, T; Lindgren, AE; Andersson, CD; Caraballo, R; Thorsell, AG; Karlberg, T; Spjut, S; Linusson, A; Schüler, H; Elofsson, M Eur J Med Chem 95: 546 -51 (2015) Altimari, JM; Niranjan, B; Risbridger, GP; Schweiker, SS; Lohning, AE; Henderson, LC Bioorg Med Chem 22: 2692 -706 (2014) ALLEN, JR; AMEGADZIE, A; BOURBEAU, MP; BROWN, JA; CHEN, JJ; CHENG, Y; FROHN, MJ; GUZMAN-PEREZ, A; HARRINGTON, PE; LIU, L; LIU, Q; LOW, JD; MA, VV; MANNING, J; MINATTI, AE; NGUYEN, TT; NISHIMURA, N; NORMAN, MH; PETTUS, LH; PICKRELL, AJ; QIAN, W; RUMFELT, S; RZASA, RM; SIEGMUND, AC; STEC, MM; WHITE, RD; XUE, Q US Patent US20160046618 (2016) Petrov, SA; Zyk, NY; Machulkin, AE; Beloglazkina, EK; Majouga, AG Eur J Med Chem 225: (2021) Maciag, AE; Holland, RJ; Kim, Y; Kumari, V; Luthers, CE; Sehareen, WS; Biswas, D; Morris, NL; Ji, X; Anderson, LM; Saavedra, JE; Keefer, LK J Med Chem 57: 2292 -302 (2014) Eldehna, WM; El Kerdawy, AM; Al-Ansary, GH; Al-Rashood, ST; Ali, MM; Mahmoud, AE Eur J Med Chem 163: 37 -53 (2019) Talhout, R; Villa, A; Mark, AE; Engberts, JB J Am Chem Soc 125: 10570 -9 (2003) Butler, CF; Peet, C; Mason, AE; Voice, MW; Leys, D; Munro, AW J Biol Chem 288: 25387 -99 (2013) Mould, DP; Alli, C; Bremberg, U; Cartic, S; Jordan, AM; Geitmann, M; Maiques-Diaz, A; McGonagle, AE; Somervaille, TCP; Spencer, GJ; Turlais, F; Ogilvie, D J Med Chem 60: 7984 -7999 (2017) Velezheva, VS; Brennan, PJ; Marshakov, VY; Gusev, DV; Lisichkina, IN; Peregudov, AS; Tchernousova, LN; Smirnova, TG; Andreevskaya, SN; Medvedev, AE J Med Chem 47: 3455 -61 (2004) Minatti, AE; Epstein, O; White, R; Weiss, M; Zhong, W; Low, JD US Patent US8957083 (2015) Moormann, AE; Metz, S; Toth, MV; Moore, WM; Jerome, G; Kornmeier, C; Manning, P; Hansen, DW; Pitzele, BS; Webber, RK Bioorg Med Chem Lett 11: 2651 -3 (2001) Sibley, DR; Moritz, AE; Free, RB; Steiner, JP; Southall, NT; Ferrer, M; Hu, X; Weiner, WS; Aubé, J; Frankowski, K US Patent US11634404 (2023) Milbank, JB; Knauer, CS; Augelli-Szafran, CE; Sakkab-Tan, AT; Lin, KK; Yamagata, K; Hoffman, JK; Zhuang, N; Thomas, J; Galatsis, P; Wendt, JA; Mickelson, JW; Schwarz, RD; Kinsora, JJ; Lotarski, SM; Stakich, K; Gillespie, KK; Lam, WW; Mutlib, AE Bioorg Med Chem Lett 17: 4415 -8 (2007) Wu, YJ; Davis, CD; Dworetzky, S; Fitzpatrick, WC; Harden, D; He, H; Knox, RJ; Newton, AE; Philip, T; Polson, C; Sivarao, DV; Sun, LQ; Tertyshnikova, S; Weaver, D; Yeola, S; Zoeckler, M; Sinz, MW J Med Chem 46: 3778 -81 (2003) Bankeu, JJ; Khayala, R; Lenta, BN; Noungoué, DT; Ngouela, SA; Mustafa, SA; Asaad, K; Choudhary, MI; Prigge, ST; Hasanov, R; Nkengfack, AE; Tsamo, E; Ali, MS J Nat Prod 74: 1370 -8 (2011) Fugel, W; Oberholzer, AE; Gschloessl, B; Dzikowski, R; Pressburger, N; Preu, L; Pearl, LH; Baratte, B; Ratin, M; Okun, I; Doerig, C; Kruggel, S; Lemcke, T; Meijer, L; Kunick, C J Med Chem 56: 264 -75 (2013) Ann, J; Ki, Y; Yoon, S; Kim, MS; Lee, JU; Kim, C; Lee, S; Jung, A; Baek, J; Hong, S; Choi, S; Pearce, LV; Esch, TE; Turcios, NA; Lewin, NE; Ogunjirin, AE; Herold, BK; McCall, AK; Blumberg, PM; Lee, J Bioorg Med Chem 24: 1231 -40 (2016) Li, J; Yakushi, T; Parlati, F; Mackinnon, AL; Perez, C; Ma, Y; Carter, KP; Colayco, S; Magnuson, G; Brown, B; Nguyen, K; Vasile, S; Suyama, E; Smith, LH; Sergienko, E; Pinkerton, AB; Chung, TDY; Palmer, AE; Pass, I; Hess, S; Cohen, SM; Deshaies, RJ Nat Chem Biol 13: 486 -493 (2017) Cheeseman, MD; Chessum, NE; Rye, CS; Pasqua, AE; Tucker, MJ; Wilding, B; Evans, LE; Lepri, S; Richards, M; Sharp, SY; Ali, S; Rowlands, M; O'Fee, L; Miah, A; Hayes, A; Henley, AT; Powers, M; Te Poele, R; De Billy, E; Pellegrino, L; Raynaud, F; Burke, R; van Montfort, RL; Eccles, SA; Workman, P; Jones, K J Med Chem 60: 180 -201 (2017) Lakanen, JR; Pegg, AE; Coward, JK J Med Chem 38: 2714 -27 (1995) Lin, Z; Marepally, SR; Ma, D; Myers, LK; Postlethwaite, AE; Tuckey, RC; Cheng, CY; Kim, TK; Yue, J; Slominski, AT; Miller, DD; Li, W J Med Chem 58: 7881 -7 (2015) Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE WIPO WO2022076495 (2022) Locuson, CW; Suzuki, H; Rettie, AE; Jones, JP J Med Chem 47: 6768 -76 (2004) Brodney, MA; Beck, EM; Butler, CR; Barreiro, G; Johnson, EF; Riddell, D; Parris, K; Nolan, CE; Fan, Y; Atchison, K; Gonzales, C; Robshaw, AE; Doran, SD; Bundesmann, MW; Buzon, L; Dutra, J; Henegar, K; LaChapelle, E; Hou, X; Rogers, BN; Pandit, J; Lira, R; Martinez-Alsina, L; Mikochik, P; Murray, JC; Ogilvie, K; Price, L; Sakya, SM; Yu, A; Zhang, Y; O'Neill, BT J Med Chem 58: 3223 -52 (2015) Hajipour, AR; Guo, LW; Pal, A; Mavlyutov, T; Ruoho, AE Bioorg Med Chem 19: 7435 -40 (2011) Han, C; Salyer, AE; Kim, EH; Jiang, X; Jarrard, RE; Powers, MS; Kirchhoff, AM; Salvador, TK; Chester, JA; Hockerman, GH; Colby, DA J Med Chem 56: 2456 -65 (2013) Hagen, TJ; Bergmanis, AA; Kramer, SW; Fok, KF; Schmelzer, AE; Pitzele, BS; Swenton, L; Jerome, GM; Kornmeier, CM; Moore, WM; Branson, LF; Connor, JR; Manning, PT; Currie, MG; Hallinan, EA J Med Chem 41: 3675 -83 (1998) Roshdy, E; Mustafa, M; Shaltout, AE; Radwan, MO; Ibrahim, MAA; Soliman, ME; Fujita, M; Otsuka, M; Ali, TFS Eur J Med Chem 224: (2021) Ilyinsky, NS; Shchyolkina, AK; Borisova, OF; Mamaeva, OK; Zvereva, MI; Azhibek, DM; Livshits, MA; Mitkevich, VA; Balzarini, J; Sinkevich, YB; Luzikov, YN; Dezhenkova, LG; Kolotova, ES; Shtil, AA; Shchekotikhin, AE; Kaluzhny, DN Eur J Med Chem 85: 605 -14 (2014) Hong, WD; Gibbons, PD; Leung, SC; Amewu, R; Stocks, PA; Stachulski, A; Horta, P; Cristiano, MLS; Shone, AE; Moss, D; Ardrey, A; Sharma, R; Warman, AJ; Bedingfield, PTP; Fisher, NE; Aljayyoussi, G; Mead, S; Caws, M; Berry, NG; Ward, SA; Biagini, GA; O'Neill, PM; Nixon, GL J Med Chem 60: 3703 -3726 (2017) Olaoye, OO; Watson, PR; Nawar, N; Geletu, M; Sedighi, A; Bukhari, S; Raouf, YS; Manaswiyoungkul, P; Erdogan, F; Abdeldayem, A; Cabral, AD; Hassan, MM; Toutah, K; Shouksmith, AE; Gawel, JM; Israelian, J; Radu, TB; Kachhiyapatel, N; de Araujo, ED; Christianson, DW; Gunning, PT J Med Chem 64: 2691 -2704 (2021) Shahbazi Nia, S; Hossain, MA; Ji, G; Jonnalagadda, SK; Obeng, S; Rahman, MA; Sifat, AE; Nozohouri, S; Blackwell, C; Patel, D; Thompson, J; Runyon, S; Hiranita, T; McCurdy, CR; McMahon, L; Abbruscato, TJ; Trippier, PC; Neugebauer, V; German, NA Eur J Med Chem 254: (2023) Gallegos, DA; Saurí, J; Cohen, RD; Wan, X; Videau, P; Vallota-Eastman, AO; Shaala, LA; Youssef, DTA; Williamson, RT; Martin, GE; Philmus, B; Sikora, AE; Ishmael, JE; McPhail, KL J Nat Prod 81: 1417 -1425 (2018) Paulsen, JL; Liu, J; Bolstad, DB; Smith, AE; Priestley, ND; Wright, DL; Anderson, AC Bioorg Med Chem 17: 4866 -72 (2009) Scocchera, E; Reeve, SM; Keshipeddy, S; Lombardo, MN; Hajian, B; Sochia, AE; Alverson, JB; Priestley, ND; Anderson, AC; Wright, DL ACS Med Chem Lett 7: 692 -6 (2016) Katzman, BM; Perszyk, RE; Yuan, H; Tahirovic, YA; Sotimehin, AE; Traynelis, SF; Liotta, DC Bioorg Med Chem Lett 25: 5583 -8 (2015) Kotian, PL; Babu, YS; Zhang, W; Lu, P; Spaulding, AE; Lv, W; Dang, Z; Raman, K US Patent US20250186391 (2025) Ward, J; Spath, SN; Pabst, B; Carpino, PA; Ruggeri, RB; Xing, G; Speers, AE; Cravatt, BF; Ahn, K Biochemistry 52: 9187 -201 (2013) Huang, Q; Johnson, TW; Bailey, S; Brooun, A; Bunker, KD; Burke, BJ; Collins, MR; Cook, AS; Cui, JJ; Dack, KN; Deal, JG; Deng, YL; Dinh, D; Engstrom, LD; He, M; Hoffman, J; Hoffman, RL; Johnson, PS; Kania, RS; Lam, H; Lam, JL; Le, PT; Li, Q; Lingardo, L; Liu, W; Lu, MW; McTigue, M; Palmer, CL; Richardson, PF; Sach, NW; Shen, H; Smeal, T; Smith, GL; Stewart, AE; Timofeevski, S; Tsaparikos, K; Wang, H; Zhu, H; Zhu, J; Zou, HY; Edwards, MP J Med Chem 57: 1170 -87 (2014) Stupple, PA; Walker, SR; Pinson, J; Lagiakos, HR; Lunniss, GE; Holmes, IP; Stupple, AE; Bergman, YE; Foitzik, RC; Kersten, WJ; Camerino, MA US Patent US9856252 (2018) Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Bioorg Med Chem Lett 27: 3431 -3435 (2017) Richardson, CM; Williamson, DS; Parratt, MJ; Borgognoni, J; Cansfield, AD; Dokurno, P; Francis, GL; Howes, R; Moore, JD; Murray, JB; Robertson, A; Surgenor, AE; Torrance, CJ Bioorg Med Chem Lett 16: 1353 -7 (2006) Hurt, DE; Sutton, AE; Clardy, J Bioorg Med Chem Lett 16: 1610 -5 (2006) CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE US Patent US20240059691 (2024) Bolognesi, ML; Ojala, WH; Gleason, WB; Griffin, JF; Farouz-Grant, F; Larson, DL; Takemori, AE; Portoghese, PS J Med Chem 39: 1816 -22 (1996) Rienhoff, Jr., HY; McCall, JM; Clare, M; Celatka, C; Tapper, AE US Patent US10519118 (2019) Yang, W; Lu, W; Lu, Y; Zhong, M; Sun, J; Thomas, AE; Wilkinson, JM; Fucini, RV; Lam, M; Randal, M; Shi, XP; Jacobs, JW; McDowell, RS; Gordon, EM; Ballinger, MD J Med Chem 49: 839 -42 (2006) Thomsen, AE; Friedrichsen, GM; Sørensen, AH; Andersen, R; Nielsen, CU; Brodin, B; Begtrup, M; Frokjaer, S; Steffansen, B J Control Release 86: 279 -92 (2003) Wityak, J; Sielecki, TM; Pinto, DJ; Emmett, G; Sze, JY; Liu, J; Tobin, AE; Wang, S; Jiang, B; Ma, P; Mousa, SA; Wexler, RR; Olson, RE J Med Chem 40: 50 -60 (1997) Zhang, H; Li, J; Toth, K; Tollefson, AE; Jing, L; Gao, S; Liu, X; Zhan, P Bioorg Med Chem 96: (2023) Zhong, S; Chen, X; Zhu, X; Dziegielewska, B; Bachman, KE; Ellenberger, T; Ballin, JD; Wilson, GM; Tomkinson, AE; MacKerell, AD J Med Chem 51: 4553 -62 (2008) Trane, AE; Pavlov, D; Sharma, A; Saqib, U; Lau, K; van Petegem, F; Minshall, RD; Roman, LJ; Bernatchez, PN J Biol Chem 289: 13273 -83 (2014) Wang, M; Winneroski, LL; Ardecky, RJ; Babine, RE; Brooks, DA; Etgen, GJ; Hutchison, DR; Kauffman, RF; Kunkel, A; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, MK; Rito, CJ; Rungta, DK; Tripp, AE; Wilson, SB; Xu, Y; Zink, RW; McCarthy, JR Bioorg Med Chem Lett 14: 6113 -6 (2004) Trojniak, AE; Dang, VQ; Czekner, KM; Russo, RJ; Mather, LM; Stahl, EL; Cameron, MD; Bohn, LM; Aubé, J Eur J Med Chem 276: Zhang, M; Aguilar, A; Xu, S; Huang, L; Chinnaswamy, K; Sleger, T; Wang, B; Gross, S; Nicolay, BN; Ronseaux, S; Harvey, K; Wang, Y; McEachern, D; Kirchhoff, PD; Liu, Z; Stuckey, J; Tron, AE; Liu, T; Wang, S J Med Chem 64: 10333 -10349 (2021) Graziani, D; Caligari, S; Callegari, E; De Toma, C; Longhi, M; Frigerio, F; Dilernia, R; Menegon, S; Pinzi, L; Pirona, L; Tazzari, V; Valsecchi, AE; Vistoli, G; Rastelli, G; Riva, C J Med Chem 62: 1246 -1273 (2019) Londregan, AT; Aitmakhanova, K; Bennett, J; Byrnes, LJ; Canterbury, DP; Cheng, X; Christott, T; Clemens, J; Coffey, SB; Dias, JM; Dowling, MS; Farnie, G; Fedorov, O; Fennell, KF; Gamble, V; Gileadi, C; Giroud, C; Harris, MR; Hollingshead, BD; Huber, K; Korczynska, M; Lapham, K; Loria, PM; Narayanan, A; Owen, DR; Raux, B; Sahasrabudhe, PV; Ruggeri, RB; Sáez, LD; Stock, IA; Thuma, BA; Tsai, A; Varghese, AE J Med Chem 66: 460 -472 (2023) Recio, E; Musso-Buendía, A; Vidal, AE; Ruda, GF; Kasinathan, G; Nguyen, C; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Eur J Med Chem 46: 3309 -14 (2011) Turner, LD; Nielsen, AL; Lin, L; Campedelli, AJ; Silvaggi, NR; Chen, JS; Wakefield, AE; Allen, KN; Janda, KD ACS Med Chem Lett 12: 1318 -1324 (2021) Wakeling, AE; Guy, SP; Woodburn, JR; Ashton, SE; Curry, BJ; Barker, AJ; Gibson, KH Cancer Res 62: 5749 -54 Vandeusen, CL; Walts, AE; Or, YS US Patent US11753403 (2023) Wammes, AE; Hendriks, TG; Amatdjais-Groenen, HI; Wijdeven, MA; van Hest, JC; van Delft, FL; Ritschel, T; Rutjes, FP Bioorg Med Chem 22: 5593 -603 (2014) Chen, P; Caldwell, CG; Mathvink, RJ; Leiting, B; Marsilio, F; Patel, RA; Wu, JK; He, H; Lyons, KA; Thornberry, NA; Weber, AE Bioorg Med Chem Lett 17: 5853 -7 (2007) Klutchko, S; Blankley, CJ; Fleming, RW; Hinkley, JM; Werner, AE; Nordin, I; Holmes, A; Hoefle, ML; Cohen, DM; Essenburg, AD J Med Chem 29: 1953 -61 (1986) Odell, LR; Howan, D; Gordon, CP; Robertson, MJ; Chau, N; Mariana, A; Whiting, AE; Abagyan, R; Daniel, JA; Gorgani, NN; Robinson, PJ; McCluskey, A J Med Chem 53: 5267 -80 (2010) Soukarieh, F; Nowicki, MW; Bastide, A; Pöyry, T; Jones, C; Dudek, K; Patwardhan, G; Meullenet, F; Oldham, NJ; Walkinshaw, MD; Willis, AE; Fischer, PM Eur J Med Chem 124: 200 -217 (2016) Park, CM; Sun, C; Olejniczak, ET; Wilson, AE; Meadows, RP; Betz, SF; Elmore, SW; Fesik, SW Bioorg Med Chem Lett 15: 771 -5 (2005) Xu, R; Zanotti-Fregonara, P; Zoghbi, SS; Gladding, RL; Woock, AE; Innis, RB; Pike, VW J Med Chem 56: 9146 -55 (2013) Killday, KB; Yarwood, D; Sills, MA; Murphy, PT; Hooper, JN; Wright, AE J Nat Prod 64: 525 -6 (2001) Wróblewski, AE; Glowacka, IE; Piotrowska, DG Eur J Med Chem 118: 121 -42 (2016) Hutchinson, JH; Halczenko, W; Brashear, KM; Breslin, MJ; Coleman, PJ; Duong, le T; Fernandez-Metzler, C; Gentile, MA; Fisher, JE; Hartman, GD; Huff, JR; Kimmel, DB; Leu, CT; Meissner, RS; Merkle, K; Nagy, R; Pennypacker, B; Perkins, JJ; Prueksaritanont, T; Rodan, GA; Varga, SL; Wesolowski, GA; Zartman, AE; Rodan, SB; Duggan, ME J Med Chem 46: 4790 -8 (2003) Hoffmann, G; Breitenbücher, F; Schuler, M; Ehrenhofer-Murray, AE J Biol Chem 289: 5208 -16 (2014) Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C US Patent US11447504 (2022) Schulze, VK; Klar, U; Kosemund, D; Wengner, AM; Siemeister, G; Stöckigt, D; Neuhaus, R; Lienau, P; Bader, B; Prechtl, S; Holton, SJ; Briem, H; Marquardt, T; Schirok, H; Jautelat, R; Bohlmann, R; Nguyen, D; Fernández-Montalván, AE; Bömer, U; Eberspaecher, U; Brüning, M; Döhr, O; Raschke, M; Kreft, B; Mumberg, D; Ziegelbauer, K; Brands, M; von Nussbaum, F; Koppitz, M J Med Chem 63: 8025 -8042 (2020) Kulén, M; Lindgren, M; Hansen, S; Cairns, AG; Grundström, C; Begum, A; van der Lingen, I; Brännström, K; Hall, M; Sauer, UH; Johansson, J; Sauer-Eriksson, AE; Almqvist, F J Med Chem 61: 4165 -4175 (2018) Sawyer, TK; Pals, DT; Mao, B; Staples, DJ; de Vaux, AE; Maggiora, LL; Affholter, JA; Kati, W; Duchamp, D; Hester, JB J Med Chem 31: 18 -30 (1988) Kümmerle, AE; Schmitt, M; Cardozo, SV; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CA; Bourguignon, JJ; Barreiro, EJ J Med Chem 55: 7525 -45 (2012) Fröhlich, RF; Fantur, K; Furneaux, RH; Paschke, E; Stütz, AE; Wicki, J; Withers, SG; Wrodnigg, TM Bioorg Med Chem Lett 21: 6872 -5 (2011) Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E Bioorg Med Chem Lett 2: 27 -32 (1992) Salah, M; Abdelsamie, AS; Frotscher, M J Med Chem 60: 4086 -4092 (2017) Bonardi, A; Nocentini, A; Giovannuzzi, S; Paoletti, N; Ammara, A; Bua, S; Abutaleb, NS; Abdelsattar, AS; Capasso, C; Gratteri, P; Flaherty, DP; Seleem, MN; Supuran, CT J Med Chem 67: 9613 -9627 Aboraia, AS; Makowski, B; Bahja, A; Prosser, D; Brancale, A; Jones, G; Simons, C Eur J Med Chem 45: 4427 -34 (2010) Meco-Navas, A; Ebiloma, GU; Martín-Domínguez, A; Martínez-Benayas, I; Cueto-Díaz, EJ; Alhejely, AS; Balogun, EO; Saito, M; Matsui, M; Arai, N; Shiba, T; Harada, S; de Koning, HP; Dardonville, C ACS Med Chem Lett 9: 923 -928 (2018) Sauerberg, P; Pettersson, I; Jeppesen, L; Bury, PS; Mogensen, JP; Wassermann, K; Brand, CL; Sturis, J; Wöldike, HF; Fleckner, J; Andersen, AS; Mortensen, SB; Svensson, LA; Rasmussen, HB; Lehmann, SV; Polivka, Z; Sindelar, K; Panajotova, V; Ynddal, L; Wulff, EM J Med Chem 45: 789 -804 (2002) Antipas, AS; Blumberg, LC; Brissette, WH; Brown, MF; Casavant, JM; Doty, JL; Driscoll, J; Harris, TM; Jones, CS; McCurdy, SP; McElroy, E; Mitton-Fry, M; Munchhof, MJ; Reim, DA; Reiter, LA; Ripp, SL; Shavnya, A; Smeets, MI; Trevena, KA Bioorg Med Chem Lett 20: 4069 -72 (2010) Garcin, ED; Arvai, AS; Rosenfeld, RJ; Kroeger, MD; Crane, BR; Andersson, G; Andrews, G; Hamley, PJ; Mallinder, PR; Nicholls, DJ; St-Gallay, SA; Tinker, AC; Gensmantel, NP; Mete, A; Cheshire, DR; Connolly, S; Stuehr, DJ; Aberg, A; Wallace, AV; Tainer, JA; Getzoff, ED Nat Chem Biol 4: 700 -7 (2008) Ashhurst, AS; Tang, AH; Fajtová, P; Yoon, MC; Aggarwal, A; Bedding, MJ; Stoye, A; Beretta, L; Pwee, D; Drelich, A; Skinner, D; Li, L; Meek, TD; McKerrow, JH; Hook, V; Tseng, CT; Larance, M; Turville, S; Gerwick, WH; O'Donoghue, AJ; Payne, RJ J Med Chem 65: 2956 -2970 (2022) BELL, AS; BESNARD, J; BRADLEY, AR; GREEN, L; HAAP, W; KOCER, B; KUGLSTATTER, A; LUCAS, X; MATTEI, P; MAZUNIN, D; RIEMER, C; VAN HOORN, WP US Patent US20230382911 (2023) Anzini, M; Cappelli, A; Vomero, S; Giorgi, G; Langer, T; Bruni, G; Romeo, MR; Basile, AS J Med Chem 39: 4275 -84 (1996) Yoshinaga, H; Ikuma, Y; Ikeda, J; Adachi, S; Mitsunuma, H; Aihara, Y; Besnard, J; Bell, AS US Patent US10745401 (2020) Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC US Patent US9598370 (2017) Braverman, AS; Tibb, AS; Ruggieri, MR J Pharmacol Exp Ther 316: 869 -74 (2006) Bentley, JR., J; Parrott, SA; Brearley, AS; Bosanac, T; Hughes, RO; Devraj, R US Patent US20230271957 (2023) Fritzen, EL; Brightwell, AS; Erickson, LA; Romero, DL Bioorg Med Chem Lett 10: 649 -52 (2000) Manning, DD; Cioffi, CL; Usyatinsky, A; Fitzpatrick, K; Masih, L; Guo, C; Zhang, Z; Choo, SH; Sikkander, MI; Ryan, KN; Naginskaya, J; Hassler, C; Dobritsa, S; Wierschke, JD; Earley, WG; Butler, AS; Brady, CA; Barnes, NM; Cohen, ML; Guzzo, PR Bioorg Med Chem Lett 21: 58 -61 (2010) Cui, H; Carlson, AS; Schleiff, MA; Divakaran, A; Johnson, JA; Buchholz, CR; Zahid, H; Vail, NR; Shi, K; Aihara, H; Harki, DA; Miller, GP; Topczewski, JJ; Pomerantz, WCK J Med Chem 64: 10497 -10511 (2021) Chaikuad, A; Diharce, J; Schröder, M; Foucourt, A; Leblond, B; Casagrande, AS; Désiré, L; Bonnet, P; Knapp, S; Besson, T J Med Chem 59: 10315 -10321 (2016) Castanet, AS; Nafie, MS; Said, SA; Arafa, RK Eur J Med Chem 250: (2023) Goyard, D; Kónya, B; Chajistamatiou, AS; Chrysina, ED; Leroy, J; Balzarin, S; Tournier, M; Tousch, D; Petit, P; Duret, C; Maurel, P; Somsák, L; Docsa, T; Gergely, P; Praly, JP; Azay-Milhau, J; Vidal, S Eur J Med Chem 108: 444 -54 (2016) Tang, H; Ning, FX; Wei, YB; Huang, SL; Huang, ZS; Chan, AS; Gu, LQ Bioorg Med Chem Lett 17: 3765 -8 (2007) He, S; Ye, Z; Dobbelaar, PH; Bakshi, RK; Hong, Q; Dellureficio, JP; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Reibarkh, M; Holmes, MA; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Bioorg Med Chem Lett 20: 6524 -32 (2010) Sun, P; Wang, J; Khan, KS; Yang, W; Ng, BW; Ilment, N; Zessin, M; Bülbül, EF; Robaa, D; Erdmann, F; Schmidt, M; Romier, C; Schutkowski, M; Cheng, AS; Sippl, W J Med Chem 65: 16313 -16337 (2022) Chintakrindi, AS; Gohil, DJ; Chowdhary, AS; Kanyalkar, MA Bioorg Med Chem 28: (2020) Chintakrindi, AS; Gohil, DJ; Chowdhary, AS; Kanyalkar, MA Bioorg Med Chem 28: (2020) Gehling, VS; Vaswani, RG; Nasveschuk, CG; Duplessis, M; Iyer, P; Balasubramanian, S; Zhao, F; Good, AC; Campbell, R; Lee, C; Dakin, LA; Cook, AS; Gagnon, A; Harmange, JC; Audia, JE; Cummings, RT; Normant, E; Trojer, P; Albrecht, BK Bioorg Med Chem Lett 25: 3644 -9 (2015) Wang, X; Liu, L; Huang, L; Herbst-Robinson, K; Cornec, AS; James, MJ; Sugiyama, S; Bassetto, M; Brancale, A; Trojanowski, JQ; Lee, VM; Smith, AB; Brunden, KR; Ballatore, C ACS Med Chem Lett 5: 1015 -20 (2014) Geldenhuys, WJ; Yonutas, HM; Morris, DL; Sullivan, PG; Darvesh, AS; Leeper, TC Bioorg Med Chem Lett 26: 5350 -5353 (2016) Christopher, JA; Aves, SJ; Bennett, KA; Doré, AS; Errey, JC; Jazayeri, A; Marshall, FH; Okrasa, K; Serrano-Vega, MJ; Tehan, BG; Wiggin, GR; Congreve, M J Med Chem 58: 6653 -64 (2015) Dou, XZ; Nath, D; Shin, Y; Ma, JX; Duerfeldt, AS Bioorg Med Chem Lett 28: 2717 -2722 (2018) Dutta, AS; Gormley, JJ; Graham, AS; Briggs, I; Growcott, JW; Jamieson, A J Med Chem 29: 1171 -8 (1987) Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C J Med Chem 56: 2747 -63 (2013) New, JS; Yevich, JP; Eison, MS; Taylor, DP; Eison, AS; Riblet, LA; VanderMaelen, CP; Temple, DL J Med Chem 29: 1476 -82 (1986) Lehr, M; Klimt, M; Elfringhoff, AS Bioorg Med Chem Lett 11: 2569 -72 (2001) Machulkin, AE; Uspenskaya, AA; Zyk, NY; Nimenko, EA; Ber, AP; Petrov, SA; Shafikov, RR; Skvortsov, DA; Smirnova, GB; Borisova, YA; Pokrovsky, VS; Kolmogorov, VS; Vaneev, AN; Ivanenkov, YA; Khudyakov, AD; Kovalev, SV; Erofeev, AS; Gorelkin, PV; Beloglazkina, EK; Zyk, NV; Khazanova, ES; Majouga, AG Eur J Med Chem 227: (2022) Stanton, MG; Stauffer, SR; Gregro, AR; Steinbeiser, M; Nantermet, P; Sankaranarayanan, S; Price, EA; Wu, G; Crouthamel, MC; Ellis, J; Lai, MT; Espeseth, AS; Shi, XP; Jin, L; Colussi, D; Pietrak, B; Huang, Q; Xu, M; Simon, AJ; Graham, SL; Vacca, JP; Selnick, H J Med Chem 50: 3431 -3 (2007) Aldrich, LN; Burdette, JE; Carcache de Blanco, E; Coss, CC; Eustaquio, AS; Fuchs, JR; Kinghorn, AD; MacFarlane, A; Mize, BK; Oberlies, NH; Orjala, J; Pearce, CJ; Phelps, MA; Rakotondraibe, LH; Ren, Y; Soejarto, DD; Stockwell, BR; Yalowich, JC; Zhang, X J Nat Prod 85: 702 -719 (2022) Basse, N; Papapostolou, D; Pagano, M; Reboud-Ravaux, M; Bernard, E; Felten, AS; Vanderesse, R Bioorg Med Chem Lett 16: 3277 -81 (2006) Chopko, TC; Han, C; Gregro, AR; Engers, DW; Felts, AS; Poslusney, MS; Bollinger, KA; Morrison, RD; Bubser, M; Lamsal, A; Luscombe, VB; Cho, HP; Schnetz-Boutaud, NC; Rodriguez, AL; Chang, S; Daniels, JS; Stec, DF; Niswender, CM; Jones, CK; Wood, MR; Wood, MW; Duggan, ME; Brandon, NJ; Conn, PJ; Bridges, TM; Lindsley, CW; Melancon, BJ Bioorg Med Chem Lett 29: 2224 -2228 (2019) Curtin, ML; Davidsen, SK; Heyman, HR; Garland, RB; Sheppard, GS; Florjancic, AS; Xu, L; Carrera, GM; Steinman, DH; Trautmann, JA; Albert, DH; Magoc, TJ; Tapang, P; Rhein, DA; Conway, RG; Luo, G; Denissen, JF; Marsh, KC; Morgan, DW; Summers, JB J Med Chem 41: 74 -95 (1998) Carlson, DA; Franke, AS; Weitzel, DH; Speer, BL; Hughes, PF; Hagerty, L; Fortner, CN; Veal, JM; Barta, TE; Zieba, BJ; Somlyo, AV; Sutherland, C; Deng, JT; Walsh, MP; Macdonald, JA; Haystead, TA ACS Chem Biol 8: 2715 -23 (2013) Wilson, JE; Patel, G; Patel, C; Brucelle, F; Huhn, A; Gardberg, AS; Poy, F; Cantone, N; Bommi-Reddy, A; Sims, RJ; Cummings, RT; Levell, JR ACS Med Chem Lett 11: 1324 -1329 (2020) Sheahan, TP; Sims, AC; Zhou, S; Graham, RL; Pruijssers, AJ; Agostini, ML; Leist, SR; Schäfer, A; Dinnon, KH; Stevens, LJ; Chappell, JD; Lu, X; Hughes, TM; George, AS; Hill, CS; Montgomery, SA; Brown, AJ; Bluemling, GR; Natchus, MG; Saindane, M; Kolykhalov, AA; Painter, G; Harcourt, J; Tamin, A; Thornburg, NJ; Swanstrom, R; Denison, MR; Baric, RS Sci Transl Med 12: 1 -15 (2020) Guariento, S; Tonelli, M; Espinoza, S; Gerasimov, AS; Gainetdinov, RR; Cichero, E Eur J Med Chem 146: 171 -184 (2018) Patel, S; Cohen, F; Dean, BJ; De La Torre, K; Deshmukh, G; Estrada, AA; Ghosh, AS; Gibbons, P; Gustafson, A; Huestis, MP; Le Pichon, CE; Lin, H; Liu, W; Liu, X; Liu, Y; Ly, CQ; Lyssikatos, JP; Ma, C; Scearce-Levie, K; Shin, YG; Solanoy, H; Stark, KL; Wang, J; Wang, B; Zhao, X; Lewcock, JW; Siu, M J Med Chem 58: 401 -18 (2015) Abdullaziz, MA; Abdel-Mohsen, HT; El Kerdawy, AM; Ragab, FAF; Ali, MM; Abu-Bakr, SM; Girgis, AS; El Diwani, HI Eur J Med Chem 136: 315 -329 (2017) McKeown, SC; Corbett, DF; Goetz, AS; Littleton, TR; Bigham, E; Briscoe, CP; Peat, AJ; Watson, SP; Hickey, DM Bioorg Med Chem Lett 17: 1584 -9 (2007) Goldstein, AS; Frye, LL J Med Chem 39: 5092 -9 (1997) Oliveira, IA; Gonçalves, AS; Neves, JL; von Itzstein, M; Todeschini, AR J Biol Chem 289: 423 -36 (2014) Frimurer, TM; Mende, F; Graae, AS; Engelstoft, MS; Egerod, KL; Nygaard, R; Gerlach, LO; Hansen, JB; Schwartz, TW; Holst, B J Med Chem 60: 886 -898 (2017) Dutta, AS; Gormley, JJ; Graham, AS; Briggs, I; Growcott, JW; Jamieson, A J Med Chem 29: 1171 -8 (1987) Thakur, A; Chu, YH; Rao, NV; Mathew, J; Grewal, AS; Prabakaran, P; Guru, S; Liou, JP; Pan, CH; Nepali, K Eur J Med Chem 273: Kim, SK; Gao, ZG; Van Rompaey, P; Gross, AS; Chen, A; Van Calenbergh, S; Jacobson, KA J Med Chem 46: 4847 -59 (2003) Galambos, J; Bielik, A; Krasavin, M; Orgován, Z; Domány, G; Nógrádi, K; Wágner, G; Balogh, GT; Béni, Z; Kóti, J; Szakács, Z; Bobok, A; Kolok, S; Mikó-Bakk, ML; Vastag, M; Sághy, K; Laszy, J; Halász, AS; Balázs, O; Gál, K; Greiner, I; Szombathelyi, Z; Keseru, GM J Med Chem 60: 2470 -2484 (2017) Da Silva, O; Probst, N; Landry, C; Hanak, AS; Warnault, P; Coisne, C; Calas, AG; Gosselet, F; Courageux, C; Gastellier, AJ; Trancart, M; Baati, R; Dehouck, MP; Jean, L; Nachon, F; Renard, PY; Dias, J J Med Chem 65: 4649 -4666 (2022) Sharma, SK; Wu, Y; Steinbergs, N; Crowley, ML; Hanson, AS; Casero, RA; Woster, PM J Med Chem 53: 5197 -212 (2010) Peiffer, AL; Garlick, JM; Wu, Y; Wotring, JW; Arora, S; Harmata, AS; Bochar, DA; Stephenson, CJ; Soellner, MB; Sexton, JZ; Brooks, CL; Mapp, AK ACS Med Chem Lett 14: 860 -866 (2023) Foley, MA; Hassman, AS; Drewry, DH; Greer, DG; Wagner, CD; Feldman, PL; Berman, J; Bickett, DM; McGeehan, GM; Lambert, MH; Green, M Bioorg Med Chem Lett 6: 1905 -1910 (1996) Hernandez-Olmos, V; Heering, J; Marinescu, B; Schermeng, T; Ivanov, VV; Moroz, YS; Nevermann, S; Mathes, M; Ehrler, JHM; Alnouri, MW; Wolf, M; Haydo, AS; Schmachtel, T; Zaliani, A; Höfner, G; Kaiser, A; Schubert-Zsilavecz, M; Beck-Sickinger, AG; Offermanns, S; Gribbon, P; Rieger, MA; Merk, D; Sisignano, M; Steinhilber, D; Proschak, E J Med Chem 67: 10567 -10588 Heimann, AS; Gomes, I; Dale, CS; Pagano, RL; Gupta, A; de Souza, LL; Luchessi, AD; Castro, LM; Giorgi, R; Rioli, V; Ferro, ES; Devi, LA Proc Natl Acad Sci U S A 104: 20588 -93 (2007) Ahmad, S; Washburn, WN; Hernandez, AS; Bisaha, S; Ngu, K; Wang, W; Pelleymounter, MA; Longhi, D; Flynn, N; Azzara, AV; Rohrbach, K; Devenny, J; Rooney, S; Thomas, M; Glick, S; Godonis, H; Harvey, S; Zhang, H; Gemzik, B; Janovitz, EB; Huang, C; Zhang, L; Robl, JA; Murphy, BJ J Med Chem 59: 8848 -8858 (2016) Shi, Y; Li, J; Kennedy, LJ; Tao, S; Hernández, AS; Lai, Z; Chen, S; Wong, H; Zhu, J; Trehan, A; Lim, NK; Zhang, H; Chen, BC; Locke, KT; O'Malley, KM; Zhang, L; Srivastava, RA; Miao, B; Meyers, DS; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Harrity, T; Kunselman, LK; Cap, M; Muckelbauer, J; Chang, C; Krystek, SR; Li, YX; Hosagrahara, V; Zhang, L; Kadiyala, P; Xu, C; Blanar, MA; Zahler, R; Mukherjee, R; Cheng, PT; Tino, JA ACS Med Chem Lett 7: 590 -4 (2016) Staroń, J; Pietruś, W; Bugno, R; Kurczab, R; Satała, G; Warszycki, D; Lenda, T; Wantuch, A; Hogendorf, AS; Hogendorf, A; Duszyńska, B; Bojarski, AJ Eur J Med Chem 220: (2021) Copinga, S; Tepper, PG; Grol, CJ; Horn, AS; Dubocovich, ML J Med Chem 36: 2891 -8 (1993) Huart, AS; Saxty, B; Merritt, A; Nekulova, M; Lewis, S; Huang, Y; Vojtesek, B; Kettleborough, C; Hupp, TR Bioorg Med Chem Lett 23: 5578 -85 (2013) Huynh, AS; Chung, WJ; Cho, HI; Moberg, VE; Celis, E; Morse, DL; Vagner, J J Med Chem 55: 9751 -62 (2012) Llona-Minguez, S; Höglund, A; Jacques, SA; Johansson, L; Calderón-Montaño, JM; Claesson, M; Loseva, O; Valerie, NC; Lundbäck, T; Piedrafita, J; Maga, G; Crespan, E; Meijer, L; Burgos Morón, E; Baranczewski, P; Hagbjörk, AL; Svensson, R; Wiita, E; Almlöf, I; Visnes, T; Jeppsson, F; Sigmundsson, K; Jensen, AJ; Artursson, P; Jemth, AS; Stenmark, P; Warpman Berglund, U; Scobie, M; Helleday, T J Med Chem 59: 1140 -8 (2016) Lewis, RT; Blackaby, WP; Blackburn, T; Jennings, AS; Pike, A; Wilson, RA; Hallett, DJ; Cook, SM; Ferris, P; Marshall, GR; Reynolds, DS; Sheppard, WF; Smith, AJ; Sohal, B; Stanley, J; Tye, SJ; Wafford, KA; Atack, JR J Med Chem 49: 2600 -10 (2006) Andrews, MD; Fish, PV; Blagg, J; Brabham, TK; Brennan, PE; Bridgeland, A; Brown, AD; Bungay, PJ; Conlon, KM; Edmunds, NJ; af Forselles, K; Gibbons, CP; Green, MP; Hanton, G; Holbrook, M; Jessiman, AS; McIntosh, K; McMurray, G; Nichols, CL; Root, JA; Storer, RI; Sutton, MR; Ward, RV; Westbrook, D; Whitlock, GA Bioorg Med Chem Lett 21: 2715 -20 (2011) Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S J Med Chem 53: 8508 -22 (2010) Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Johnson, AS; Stocking, EM; Swanson, DM US Patent US11059828 (2021) Knudsen, LB; Kiel, D; Teng, M; Behrens, C; Bhumralkar, D; Kodra, JT; Holst, JJ; Jeppesen, CB; Johnson, MD; de Jong, JC; Jorgensen, AS; Kercher, T; Kostrowicki, J; Madsen, P; Olesen, PH; Petersen, JS; Poulsen, F; Sidelmann, UG; Sturis, J; Truesdale, L; May, J; Lau, J Proc Natl Acad Sci U S A 104: 937 -42 (2007) Iyengar, RR; Lynch, JK; Mulhern, MM; Judd, AS; Freeman, JC; Gao, J; Souers, AJ; Zhao, G; Wodka, D; Doug Falls, H; Brodjian, S; Dayton, BD; Reilly, RM; Swanson, S; Su, Z; Martin, RL; Leitza, ST; Houseman, KA; Diaz, G; Collins, CA; Sham, HL; Kym, PR Bioorg Med Chem Lett 17: 874 -8 (2007) Jørgensen, AS; Jacobsen, P; Christiansen, LB; Bury, PS; Kanstrup, A; Thorpe, SM; Bain, S; Naerum, L; Wassermann, K Bioorg Med Chem Lett 10: 399 -402 (2000) Blöcher, R; Lamers, C; Wittmann, SK; Merk, D; Hartmann, M; Weizel, L; Diehl, O; Brüggerhoff, A; Boß, M; Kaiser, A; Schader, T; Göbel, T; Grundmann, M; Angioni, C; Heering, J; Geisslinger, G; Wurglics, M; Kostenis, E; Brüne, B; Steinhilber, D; Schubert-Zsilavecz, M; Kahnt, AS; Proschak, E J Med Chem 59: 61 -81 (2016) Cerny, MA; Kalgutkar, AS; Obach, RS; Sharma, R; Spracklin, DK; Walker, GS J Med Chem 63: 6387 -6406 (2020) Bockman, MR; Kalinda, AS; Petrelli, R; De la Mora-Rey, T; Tiwari, D; Liu, F; Dawadi, S; Nandakumar, M; Rhee, KY; Schnappinger, D; Finzel, BC; Aldrich, CC J Med Chem 58: 7349 -69 (2015) Aspnes, GE; Coffey, SB; Darout, E; Dechert-Schmitt, AM; Dullea, RG; Kamlet, AS; Limberakis, C; Londregan, AT; McClure, KF; Menhaji-Klotz, E; Piotrowski, DW; Polivkova, J; Raymer, B; Ruggeri, RB; Salatto, CT; Tu, M; Wei, L; Xiao, J Bioorg Med Chem Lett 92: (2023) Bai, B; Belovodskiy, A; Hena, M; Kandadai, AS; Joyce, MA; Saffran, HA; Shields, JA; Khan, MB; Arutyunova, E; Lu, J; Bajwa, SK; Hockman, D; Fischer, C; Lamer, T; Vuong, W; van Belkum, MJ; Gu, Z; Lin, F; Du, Y; Xu, J; Rahim, M; Young, HS; Vederas, JC; Tyrrell, DL; Lemieux, MJ; Nieman, JA J Med Chem (2021) Schepetkin, IA; Karpenko, AS; Khlebnikov, AI; Shibinska, MO; Levandovskiy, IA; Kirpotina, LN; Danilenko, NV; Quinn, MT Eur J Med Chem 183: (2019) Karpov, AS; Amiri, P; Bellamacina, C; Bellance, MH; Breitenstein, W; Daniel, D; Denay, R; Fabbro, D; Fernandez, C; Galuba, I; Guerro-Lagasse, S; Gutmann, S; Hinh, L; Jahnke, W; Klopp, J; Lai, A; Lindvall, MK; Ma, S; Möbitz, H; Pecchi, S; Rummel, G; Shoemaker, K; Trappe, J; Voliva, C; Cowan-Jacob, SW; Marzinzik, AL ACS Med Chem Lett 6: 776 -81 (2015) DeVries, VG; Bloom, JD; Dutia, MD; Katocs, AS; Largis, EE J Med Chem 32: 2318 -25 (1989) Jones, LH; Baldock, H; Bunnage, ME; Burrows, J; Clarke, N; Coghlan, M; Entwistle, D; Fairman, D; Feeder, N; Fulton, C; Hilton, L; James, K; Jones, RM; Kenyon, AS; Marshall, S; Newman, SD; Osborne, R; Patel, S; Selby, MD; Stuart, EF; Trevethick, MA; Wright, KN; Price, DA Bioorg Med Chem Lett 21: 2759 -63 (2011) Bell, IM; Stirdivant, SM; Ahern, J; Culberson, JC; Darke, PL; Dinsmore, CJ; Drakas, RA; Gallicchio, SN; Graham, SL; Heimbrook, DC; Hall, DL; Hua, J; Kett, NR; Kim, AS; Kornienko, M; Kuo, LC; Munshi, SK; Quigley, AG; Reid, JC; Trotter, BW; Waxman, LH; Williams, TM; Zartman, CB Biochemistry 44: 9430 -40 (2005) Horti, AG; Scheffel, U; Kimes, AS; Musachio, JL; Ravert, HT; Mathews, WB; Zhan, Y; Finley, PA; London, ED; Dannals, RF J Med Chem 41: 4199 -206 (1998) Kiselyov, AS; Semenova, M; Semenov, VV Bioorg Med Chem Lett 19: 1344 -8 (2009) Sağlık, BN; Osmaniye, D; Çevik, UA; Levent, S; Çavuşoğlu, BK; Büyükemir, O; Nezir, D; Karaduman, AB; Özkay, Y; Koparal, AS; Beydemir, Ş; Kaplancıklı, ZA Eur J Med Chem 198: (2020) Poulsen, MH; Lucas, S; Bach, TB; Barslund, AF; Wenzler, C; Jensen, CB; Kristensen, AS; Strømgaard, K J Med Chem 56: 1171 -81 (2013) Pagare, PP; Li, M; Zheng, Y; Kulkarni, AS; Obeng, S; Huang, B; Ruiz, C; Gillespie, JC; Mendez, RE; Stevens, DL; Poklis, JL; Halquist, MS; Dewey, WL; Selley, DE; Zhang, Y J Med Chem 65: 5095 -5112 (2022) Guzii, AG; Makarieva, TN; Denisenko, VA; Dmitrenok, PS; Popov, RS; Kuzmich, AS; Fedorov, SN; Krasokhin, VB; Kim, NY; Stonik, VA J Nat Prod 81: 2763 -2767 (2018) King, AJ; Patrick, DR; Batorsky, RS; Ho, ML; Do, HT; Zhang, SY; Kumar, R; Rusnak, DW; Takle, AK; Wilson, DM; Hugger, E; Wang, L; Karreth, F; Lougheed, JC; Lee, J; Chau, D; Stout, TJ; May, EW; Rominger, CM; Schaber, MD; Luo, L; Lakdawala, AS; Adams, JL; Contractor, RG; Smalley, KS; Herlyn, M; Morrissey, MM; Tuveson, DA; Huang, PS Cancer Res 66: 11100 -5 Cao, S; Lee, AS; Huang, Y; Flotow, H; Ng, S; Butler, MS; Buss, AD J Nat Prod 65: 1037 -8 (2002) Lavreysen, H; Janssen, C; Bischoff, F; Langlois, X; Leysen, JE; Lesage, AS Mol Pharmacol 63: 1082 -93 (2003) Yeh, TK; Song, JS; Chang, PW; Yu, JC; Chang, CH; Liao, FY; Tien, YW; Kuppusamy, R; Li, AS; Chen, CH; Chen, CW; Lin, LM; Chang, HH; Huang, CH; Yao, JY; Wu, MH; Peng, YH; Hsueh, CC; Hsiao, WC; Chen, PH; Lin, CY; Hsieh, SH; Shih, C; Hung, MS; Wu, SY; Kuo, CC; Ueng, SH Eur J Med Chem 229: (2022) Bata, N; Chaikuad, A; Bakas, NA; Limpert, AS; Lambert, LJ; Sheffler, DJ; Berger, LM; Liu, G; Yuan, C; Wang, L; Peng, Y; Dong, J; Celeridad, M; Layng, F; Knapp, S; Cosford, NDP J Med Chem 65: 1352 -1369 (2022) Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T J Med Chem 64: 15189 -15213 (2021) Schoenfeld, RC; Bourdet, DL; Brameld, KA; Chin, E; de Vicente, J; Fung, A; Harris, SF; Lee, EK; Le Pogam, S; Leveque, V; Li, J; Lui, AS; Najera, I; Rajyaguru, S; Sangi, M; Steiner, S; Talamas, FX; Taygerly, JP; Zhao, J J Med Chem 56: 8163 -82 (2013) Woon, EC; Zervosen, A; Sauvage, E; Simmons, KJ; Zivec, M; Inglis, SR; Fishwick, CW; Gobec, S; Charlier, P; Luxen, As ACS Med Chem Lett 2: 219 -223 (2011) Mandal, AS; Roy, K Eur J Med Chem 44: 1509 -24 (2009) Leonard, KA; Madge, LA; Krawczuk, PJ; Wang, A; Kreutter, KD; Bacani, GM; Chai, W; Smith, RC; Tichenor, MS; Harris, MC; Malaviya, R; Seierstad, M; Johnson, ME; Venable, JD; Kim, S; Hirst, GC; Mathur, AS; Rao, TS; Edwards, JP; Rizzolio, MC; Koudriakova, T J Med Chem 63: 2915 -2929 (2020) Mayhoub, AS; Marler, L; Kondratyuk, TP; Park, EJ; Pezzuto, JM; Cushman, M Bioorg Med Chem 20: 2427 -34 (2012) Lingam, VS; Dahale, DH; Rathi, VE; Shingote, YB; Thakur, RR; Mindhe, AS; Kummari, S; Khairatkar-Joshi, N; Bajpai, M; Shah, DM; Sapalya, RS; Gullapalli, S; Gupta, PK; Gudi, GS; Jadhav, SB; Pattem, R; Thomas, A J Med Chem 58: 8292 -308 (2015) Liang, GB; Qian, X; Feng, D; Fisher, M; Crumley, T; Darkin-Rattray, SJ; Dulski, PM; Gurnett, A; Leavitt, PS; Liberator, PA; Misura, AS; Samaras, S; Tamas, T; Schmatz, DM; Wyvratt, M; Biftu, T Bioorg Med Chem Lett 18: 2019 -22 (2008) Bruno, F; Errico, S; Pace, S; Nawrozkij, MB; Mkrtchyan, AS; Guida, F; Maisto, R; Olgaç, A; D'Amico, M; Maione, S; De Rosa, M; Banoglu, E; Werz, O; Fiorentino, A; Filosa, R Eur J Med Chem 155: 946 -960 (2018) Ramshini, H; Mannini, B; Khodayari, K; Ebrahim-Habibi, A; Moghaddasi, AS; Tayebee, R; Chiti, F Eur J Med Chem 124: 361 -371 (2016) Blagg, J; Bavetsias, V; Moore, AS; Linardopoulos, S US Patent US9447092 (2016) Pollastro, F; Caprioglio, D; Marotta, P; Moriello, AS; De Petrocellis, L; Taglialatela-Scafati, O; Appendino, G J Nat Prod 81: 630 -633 (2018) Abdel-Aziz, AA; Morsy, AS; Attia, SM US Patent US12139461 (2024) Neukirch, K; Alsabil, K; Dinh, CP; Bilancia, R; Raasch, M; Ville, A; Cerqua, I; Viault, G; Bréard, D; Pace, S; Temml, V; Brunner, E; Jordan, PM; Marques, MC; Loeser, K; Gollowitzer, A; Permann, S; Gerstmeier, J; Lorkowski, S; Stuppner, H; Garscha, U; Rodrigues, T; Bernardes, GJL; Schuster, D; Séraphin, D; Richomme, P; Rossi, A; Mosig, AS; Roviezzo, F; Werz, O; Helesbeux, JJ; Koeberle, A J Med Chem 64: 11496 -11526 (2021) Mostafa, AS; Selim, KB Eur J Med Chem 156: 304 -315 (2018) Wang, F; Jain, P; Gulten, G; Liu, Z; Feng, Y; Ganesula, K; Motiwala, AS; Ioerger, TR; Alland, D; Vilchèze, C; Jacobs, WR; Sacchettini, JC Antimicrob Agents Chemother 54: 3776 -82 (2010) Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL Bioorg Med Chem Lett 18: 5900 -3 (2008) da Silva, FM; dos Santos, JC; Campos, JL; Mafud, AC; Polikarpov, I; Figueira, AC; Nascimento, AS Bioorg Med Chem Lett 23: 5795 -802 (2013) Smith, GF; Altman, MD; Andresen, B; Baker, J; Brubaker, JD; Chen, H; Chen, Y; Childers, M; Donofrio, A; Ferguson, H; Fischer, C; Fischmann, TO; Gibeau, C; Hicks, A; Jin, S; Kattar, S; Kleinschek, MA; Leccese, E; Lesburg, C; Li, C; Lim, J; Liu, D; Maclean, JKF; Mansoor, F; Moy, LY; Mulrooney, EF; Necheva, AS; Presland, J; Rakhilina, L; Yang, R; Torres, L; Zhang-Hoover, J; Northrup, A Bioorg Med Chem Lett 27: 2721 -2726 (2017) Chrovian, CC; Soyode-Johnson, A; Stenne, B; Pippel, DJ; Schoellerman, J; Lord, B; Needham, AS; Xia, C; Coe, KJ; Sepassi, K; Schoetens, F; Scott, B; Nguyen, L; Jiang, X; Koudriakova, T; Balana, B; Letavic, MA J Med Chem 63: 9181 -9196 (2020) Chaturvedi, AK; Verma, AK; Thakur, JP; Roy, S; Bhushan Tripathi, S; Kumar, BS; Khwaja, S; Sachan, NK; Sharma, A; Chanda, D; Shanker, K; Saikia, D; Negi, AS Bioorg Med Chem 26: 4551 -4559 (2018) Manning, DD; Guo, C; Zhang, Z; Ryan, KN; Naginskaya, J; Choo, SH; Masih, L; Earley, WG; Wierschke, JD; Newman, AS; Brady, CA; Barnes, NM; Guzzo, PR Bioorg Med Chem Lett 24: 2578 -81 (2014) Puleo, DE; Kucera, K; Hammarén, HM; Ungureanu, D; Newton, AS; Silvennoinen, O; Jorgensen, WL; Schlessinger, J ACS Med Chem Lett 8: 618 -621 (2017) Lyle, TA; Chen, Z; Appleby, SD; Freidinger, RM; Gardell, SJ; Lewis, SD; Li, Y; Lyle, EA; Lynch, JJ; Mulichak, AM; Ng, AS; Naylor-Olsen, AM; Sanders, WM Bioorg Med Chem Lett 7: 67 -72 (1997) Clausen, RP; Naur, P; Kristensen, AS; Greenwood, JR; Strange, M; Bräuner-Osborne, H; Jensen, AA; Nielsen, AS; Geneser, U; Ringgaard, LM; Nielsen, B; Pickering, DS; Brehm, L; Gajhede, M; Krogsgaard-Larsen, P; Kastrup, JS J Med Chem 52: 4911 -22 (2009) de Souza Gama, FH; Dutra, LA; Hawgood, M; Dos Reis, CV; Serafim, RAM; Ferreira, MA; Teodoro, BVM; Takarada, JE; Santiago, AS; Balourdas, DI; Nilsson, AS; Urien, B; Almeida, VM; Gileadi, C; Ramos, PZ; Salmazo, A; Vasconcelos, SNS; Cunha, MR; Mueller, S; Knapp, S; Massirer, KB; Elkins, JM; Gileadi, O; Mascarello, A; Lemmens, BBLG; Guimarães, CRW; Azevedo, H; Couñago, RM J Med Chem 67: 8609 -8629 CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE US Patent US20240059691 (2024) Sahin, C; Magomedova, L; Ferreira, TAM; Liu, J; Tiefenbach, J; Alves, PS; Queiroz, FJG; Oliveira, AS; Bhattacharyya, M; Grouleff, J; Nogueira, PCN; Silveira, ER; Moreira, DC; Leite, JRSA; Brand, GD; Uehling, D; Poda, G; Krause, H; Cummins, CL; Romeiro, LAS J Med Chem 65: 1961 -1978 (2022) Swierczek, K; Pandey, AS; Peters, JW; Hengge, AC J Med Chem 46: 3703 -8 (2003) Feng, J; Paparella, AS; Tieu, W; Heim, D; Clark, S; Hayes, A; Booker, GW; Polyak, SW; Abell, AD ACS Med Chem Lett 7: 1068 -1072 (2016) Turner, SC; Carroll, WA; White, TK; Gopalakrishnan, M; Coghlan, MJ; Shieh, CC; Zhang, XF; Parihar, AS; Buckner, SA; Milicic, I; Sullivan, JP Bioorg Med Chem Lett 13: 2003 -7 (2003) Vishwakarma, RA; Bharate, SB; Bhushan, S; Mondhe, DM; Jain, SK; Meena, S; Guru, SK; Pathania, AS; Kumar, S; Behl, A; Mintoo, MJ; Bharate, SS; Joshi, P US Patent US9932327 (2018) Velezheva, VS; Brennan, PJ; Marshakov, VY; Gusev, DV; Lisichkina, IN; Peregudov, AS; Tchernousova, LN; Smirnova, TG; Andreevskaya, SN; Medvedev, AE J Med Chem 47: 3455 -61 (2004) Malovichko, OL; Petrus, AS; Krysko, AA; Kabanova, TA; Andronati, SA; Karaseva, TL; Kiriyak, AV Bioorg Med Chem Lett 16: 5294 -7 (2006) Strelnik, AD; Petukhov, AS; Zueva, IV; Zobov, VV; Petrov, KA; Nikolsky, EE; Balakin, KV; Bachurin, SO; Shtyrlin, YG Bioorg Med Chem Lett 26: 4092 -4 (2016) Gadhachanda, VR; Pais, G; Hashimoto, A; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS; Wiles, JA US Patent US9732104 (2017) Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Eur J Med Chem 161: 179 -191 (2019) Thomson, CG; Le Grand, D; Dowling, M; Brocklehurst, CE; Chinn, C; Elphick, L; Faller, M; Freeman, M; Furminger, V; Gasser, C; Hamadi, A; Hardaker, E; Head, V; Hill, JC; Janus, DI; Pearce, D; Poulaud, AS; Stanley, E; Sviridenko, L Bioorg Med Chem Lett 28: 2279 -2284 (2018) Prashad, AS; Wang, D; Subrath, J; Wu, B; Lin, M; Zhang, MY; Kagan, N; Lee, J; Yang, X; Brennan, A; Chaudhary, D; Xu, X; Leung, L; Wang, J; Boschelli, DH Bioorg Med Chem Lett 19: 5799 -802 (2009) Snow, RJ; Cardozo, MG; Morwick, TM; Busacca, CA; Dong, Y; Eckner, RJ; Jacober, S; Jakes, S; Kapadia, S; Lukas, S; Panzenbeck, M; Peet, GW; Peterson, JD; Prokopowicz, AS; Sellati, R; Tolbert, RM; Tschantz, MA; Moss, N J Med Chem 45: 3394 -405 (2002) Paz, JD; Denise de Moura Sperotto, N; Ramos, AS; Pissinate, K; da Silva Rodrigues Junior, V; Abbadi, BL; Borsoi, AF; Rambo, RS; Corso Minotto, AC; da Silva Dadda, A; Galina, L; Macchi Hopf, FS; Muniz, MN; Borges Martinelli, LK; Roth, CD; Madeira Silva, RB; Perelló, MA; de Matos Czeczot, A; Neves, CE; Duarte, LS; Leyser, M; Dias de Oliveira, S; Bizarro, CV; Machado, P; Basso, LA Eur J Med Chem 245: (2023) Korboukh, I; Hull-Ryde, EA; Rittiner, JE; Randhawa, AS; Coleman, J; Fitzpatrick, BJ; Setola, V; Janzen, WP; Frye, SV; Zylka, MJ; Jin, J J Med Chem 55: 6467 -77 (2012) Buynak, JD; Doppalapudi, VR; Rao, AS; Nidamarthy, SD; Adam, G Bioorg Med Chem Lett 10: 847 -51 (2000) Siegel, D; Hui, HC; Doerffler, E; Clarke, MO; Chun, K; Zhang, L; Neville, S; Carra, E; Lew, W; Ross, B; Wang, Q; Wolfe, L; Jordan, R; Soloveva, V; Knox, J; Perry, J; Perron, M; Stray, KM; Barauskas, O; Feng, JY; Xu, Y; Lee, G; Rheingold, AL; Ray, AS; Bannister, R; Strickley, R; Swaminathan, S; Lee, WA; Bavari, S; Cihlar, T; Lo, MK; Warren, TK; Mackman, RL J Med Chem 60: 1648 -1661 (2017) Semple, G; Ren, AS; Schrader, TO; Kasem, M; Zhu, X US Patent US10836764 (2020) Matthiesen, RA; Varney, ML; Xu, PC; Rier, AS; Wiemer, DF; Holstein, SA Bioorg Med Chem 26: 376 -385 (2018) Das, K; Bauman, JD; Rim, AS; Dharia, C; Clark, AD; Camarasa, MJ; Balzarini, J; Arnold, E J Med Chem 54: 2727 -37 (2011) Moran, MM; Chong, JA; Fanger, C; Ripka, AS; Larsen, GR; Zhen, X; Underwood, DJ; Weigele, M US Patent US9181219 (2015) Caleffi, GS; Rosa, AS; de Souza, LG; Avelar, JLS; Nascimento, SMR; de Almeida, VM; Tucci, AR; Ferreira, VN; da Silva, AJM; Santos-Filho, OA; Miranda, MD; Costa, PRR J Nat Prod 86: 1536 -1549 (2023) Dexheimer, TS; Rosenthal, AS; Luci, DK; Liang, Q; Villamil, MA; Chen, J; Sun, H; Kerns, EH; Simeonov, A; Jadhav, A; Zhuang, Z; Maloney, DJ J Med Chem 57: 8099 -110 (2014) Ann, J; Czikora, A; Saini, AS; Zhou, X; Mitchell, GA; Lewin, NE; Peach, ML; Blumberg, PM; Lee, J J Med Chem 61: 6261 -6276 (2018) de Souza Gama, FH; Dutra, LA; Hawgood, M; Dos Reis, CV; Serafim, RAM; Ferreira, MA; Teodoro, BVM; Takarada, JE; Santiago, AS; Balourdas, DI; Nilsson, AS; Urien, B; Almeida, VM; Gileadi, C; Ramos, PZ; Salmazo, A; Vasconcelos, SNS; Cunha, MR; Mueller, S; Knapp, S; Massirer, KB; Elkins, JM; Gileadi, O; Mascarello, A; Lemmens, BBLG; Guimarães, CRW; Azevedo, H; Couñago, RM J Med Chem 67: 8609 -8629 Budnjo, A; Narawane, S; Grauffel, C; Schillinger, AS; Fossen, T; Reuter, N; Haug, BE J Med Chem 57: 9396 -408 (2014) Kadagathur, M; Patra, S; Devabattula, G; George, J; Phanindranath, R; Shaikh, AS; Sigalapalli, DK; Godugu, C; Nagesh, N; Tangellamudi, ND; Shankaraiah, N Eur J Med Chem 238: (2022) Ansari, A; Satalkar, S; Patil, V; Shete, AS; Kaur, S; Gupta, A; Singh, S; Raja, M; Severance, DL; Bernales, S; Chakravarty, S; Hung, DT; Pham, SM; Herrera, FJ; Rai, R Bioorg Med Chem Lett 27: 217 -222 (2017) Qin, LY; Ruan, Z; Cherney, RJ; Dhar, TGM; Neels, J; Weigelt, CA; Sack, JS; Srivastava, AS; Cornelius, LAM; Tino, JA; Stefanski, K; Gu, X; Xie, J; Susulic, V; Yang, X; Yarde-Chinn, M; Skala, S; Bosnius, R; Goldstein, C; Davies, P; Ruepp, S; Salter-Cid, L; Bhide, RS; Poss, MA Bioorg Med Chem Lett 27: 855 -861 (2017) Shen, HC; Ding, FX; Wang, S; Deng, Q; Zhang, X; Chen, Y; Zhou, G; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Tsai, C; Stevenson, AS; Pai, LY; Alonso-Galicia, M; Chen, X; Soisson, SM; Roy, S; Zhang, B; Tata, JR; Berger, JP; Colletti, SL J Med Chem 52: 5009 -12 (2010) Pennington, LD; Croghan, MD; Sham, KK; Pickrell, AJ; Harrington, PE; Frohn, MJ; Lanman, BA; Reed, AB; Lee, MR; Xu, H; McElvain, M; Xu, Y; Zhang, X; Fiorino, M; Horner, M; Morrison, HG; Arnett, HA; Fotsch, C; Tasker, AS; Wong, M; Cee, VJ Bioorg Med Chem Lett 22: 527 -31 (2011) Nathubhai, A; Haikarainen, T; Hayward, PC; Muñoz-Descalzo, S; Thompson, AS; Lloyd, MD; Lehtiö, L; Threadgill, MD Eur J Med Chem 118: 316 -27 (2016) Braverman, AS; Tibb, AS; Ruggieri, MR J Pharmacol Exp Ther 316: 869 -74 (2006) Tikhomirov, AS; Shchekotikhin, AE; Lee, YH; Chen, YA; Yeh, CA; Tatarskiy, VV; Dezhenkova, LG; Glazunova, VA; Balzarini, J; Shtil, AA; Preobrazhenskaya, MN; Chueh, PJ J Med Chem 58: 9522 -34 (2015) Press, JB; Wright, WB; Chan, PS; Marsico, JW; Haug, MF; Tauber, J; Tomcufcik, AS J Med Chem 29: 816 -9 (1986) Ho, GD; Anthes, J; Bercovici, A; Caldwell, JP; Cheng, KC; Cui, X; Fawzi, A; Fernandez, X; Greenlee, WJ; Hey, J; Korfmacher, W; Lu, SX; McLeod, RL; Ng, F; Torhan, AS; Tan, Z; Tulshian, D; Varty, GB; Xu, X; Zhang, H Bioorg Med Chem Lett 19: 2519 -23 (2009) Vaidya, AS; Neelarapu, R; Madriaga, A; Bai, H; Mendonca, E; Abdelkarim, H; van Breemen, RB; Blond, SY; Petukhov, PA Bioorg Med Chem Lett 22: 6621 -7 (2012) Gurney, ME; Nugent, RA; Mo, X; Sindac, JA; Hagen, TJ; Fox, D; O'Donnell, JM; Zhang, C; Xu, Y; Zhang, HT; Groppi, VE; Bailie, M; White, RE; Romero, DL; Vellekoop, AS; Walker, JR; Surman, MD; Zhu, L; Campbell, RF J Med Chem 62: 4884 -4901 (2019) Sammelson, RE; Ma, T; Galietta, LJ; Verkman, AS; Kurth, MJ Bioorg Med Chem Lett 13: 2509 -12 (2003) Sakhuja, R; Kondabolu, K; Córdova-Sintjago, T; Travers, S; Vincek, AS; Kim, MS; Abboud, KA; Fang, L; Sun, Z; Canal, CE; Booth, RG Bioorg Med Chem 23: 1588 -600 (2015) D., AE; W., AS; Jean, BC; R., CK; C., IT; KOLAKOWSKI, KG; Manoj, K; A., ME; L., MM; Alexander, MJ; Tiphaine, M; J., MM; Dino, PT; Alexander, PM; Marta, P WIPO WO2022098970 (2022) Ni, ZJ; Barsanti, P; Brammeier, N; Diebes, A; Poon, DJ; Ng, S; Pecchi, S; Pfister, K; Renhowe, PA; Ramurthy, S; Wagman, AS; Bussiere, DE; Le, V; Zhou, Y; Jansen, JM; Ma, S; Gesner, TG Bioorg Med Chem Lett 16: 3121 -4 (2006) Plescia, J; Dufresne, C; Janmamode, N; Wahba, AS; Mittermaier, AK; Moitessier, N Eur J Med Chem 185: (2020) Schuster, VL; Chi, Y; Wasmuth, AS; Pottorf, RS; Olson, GL US Patent US8952150 (2015) Kaminski, JJ; Solomon, DM; Conn, DJ; Wong, SC; Chiu, PJ; Massa, T; Siegel, MI; Watnick, AS J Med Chem 32: 1118 -27 (1989) Walker, KA; Kertesz, DJ; Rotstein, DM; Swinney, DC; Berry, PW; So, OY; Webb, AS; Watson, DM; Mak, AY; Burton, PM J Med Chem 36: 2235 -7 (1993) Ojima, I; Dong, Q; Chakravarty, S; Peerschke, E; Hwang, SM; Wong, AS Bioorg Med Chem Lett 5: 1941 -1946 (1995) Lefker, BA; Hada, WA; Wright, AS; Martin, WH; Stock, IA; Schulte, GK; Pandit, J; Danley, DE; Ammirati, MJ; Sneddon, SF Bioorg Med Chem Lett 5: 2623 -2626 (1995) Honma, D; Kanno, O; Watanabe, J; Kinoshita, J; Hirasawa, M; Nosaka, E; Shiroishi, M; Takizawa, T; Yasumatsu, I; Horiuchi, T; Nakao, A; Suzuki, K; Yamasaki, T; Nakajima, K; Hayakawa, M; Yamazaki, T; Yadav, AS; Adachi, N Cancer Sci 108: 2069 -2078 Ho, CW; Popat, SD; Liu, TW; Tsai, KC; Ho, MJ; Chen, WH; Yang, AS; Lin, CH ACS Chem Biol 5: 489 -97 (2010) Middleton, RJ; Briddon, SJ; Cordeaux, Y; Yates, AS; Dale, CL; George, MW; Baker, JG; Hill, SJ; Kellam, B J Med Chem 50: 782 -93 (2007) Davidowitz, EJ; Moe, JG; Reitz, AB; Bian, H; Gluchowski, C; Hendrix, J; Yehaskel, AS; McDonnell, ME; Loughran, HM US Patent US20240158379 (2024) Budke, B; Kalin, JH; Pawlowski, M; Zelivianskaia, AS; Wu, M; Kozikowski, AP; Connell, PP J Med Chem 56: 254 -63 (2013) Sweeney, ZK; Acharya, S; Briggs, A; Dunn, JP; Elworthy, TR; Fretland, J; Giannetti, AM; Heilek, G; Li, Y; Kaiser, AC; Martin, M; Saito, YD; Smith, M; Suh, JM; Swallow, S; Wu, J; Hang, JQ; Zhou, AS; Klumpp, K Bioorg Med Chem Lett 18: 4348 -51 (2008)
BDBM210922 US9273043, AE
BDBM229667 US9334269, AE
US9273043, AE BDBM60942
BDBM134499 US8846656, 19-AE
BDBM204971 US9249085, I(ae)
BDBM293054 US10106501, Example AE
US20230357139, Compound AE BDBM634013
US8846656, 21-AE BDBM134516
BDBM381041 US9890185, Example 15(ae)
BDBM381108 US9890185, Example 38(ae)
BDBM660451 US20240092799, Compound XXIX-AE
US12325697, Compound AE-2 BDBM747340
BDBM35279 tripeptide-based inhibitor, 14v AE-3763
US10941115, Example 17(ae) 4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxy-phenyl]carbamoylamino]-1-naphthyl]oxy]-2-pyridyl]amino]-2,6-dimethoxy-N-(2-morpholinoethyl)benzamide US9751837, Example 17(ae) BDBM298425 US10125100, Example 17(ae) US10392346, Example 17(ae)