- pi3k-alpha/ src mutant (t338i)
- estrogen-related receptor, alpha mutant (c325s)
- map kinase p38 alpha mutant (g110a)
- map kinase p38 alpha mutant (g110d)
- 20-alpha-hydroxysteroid dehydrogenase (akr1c1) mutant (h222s)
- 20-alpha-hydroxysteroid dehydrogenase (akr1c1) mutant (l306a)
- 20-alpha-hydroxysteroid dehydrogenase (akr1c1) mutant (l54v)
- phosphoinositide 3-kinase (pi3k), alpha mutant (h1047r) chain a
- gabaa receptor mutant, alpha-1 (a160c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (d97c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (f99c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (g157c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (s204c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (t162c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (y209c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (d56c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (f77c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (l140c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r132c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r144c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r185c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r194c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (t126c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (t142c)
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform mutant
- alpha,alpha-trehalase
- alpha,alpha-trehalose glucohydrolase
- alpha-glucosidase ( alpha-glucosidase)
- alpha-glucosidase (alpha-glu)
- alpha-glucosidase (alpha-glucosidase)
- alpha-1a/alpha-1b/alpha-1d adrenergic receptor
- casein kinase ii subunit alpha/alpha 3/alpha'/beta
- integrin alpha-5/alpha-8
- integrin alpha-5/alpha-v
- integrin alpha-v/alpha-5
- voltage-dependent l-type calcium channel subunit alpha-1c/alpha-1d/alpha-1f/alpha-1s
- abl mutant (m351t)
- abl mutant (t315i)
- abl mutant (t315n)
- abl mutant (y253f)
- braf mutant v600e
- chitinase mutant (m243a)
- ksp mutant (a356t)
- noxab mutant (e74f)
- puma mutant (m144i)
- src mutant (s345c)
- src mutant (t338m)
- alpha-1a/alpha-2a adrenergic receptor
- casein kinase 1 alpha (ck1 alpha)
- nuclear receptor ror-alpha (alpha-2)
- retinoic acid receptor rxr-alpha/alpha
- peroxisome proliferator-activated receptor alpha (ppar alpha)
- voltage-dependent l-type calcium channel subunit alpha-1c/alpha-1d/alpha-1s
- cyclooxygenase-2 mutant (y355f)
- hcv ns5b mutant(s283t)
- hyhel-10 mutant (aeaf)
- hyhel-10 mutant (etkf)
- hyhel-10 mutant (hy58a)
- hyhel-10 mutant (hy58f)
- hyhel-10 mutant (sfsf)
- hyhel-5 mutant(e50d)
- hyhel-5 mutant(e50q)
- mtor/ src mutant (t338i)
- ret kinase mutant (g810r)
- src mutant (s345c/t338m)
- urokinase (upa) mutant (s190a)
- acc-alpha
- adrenergic alpha
- alpha glucosidase
- alpha-amylase
- alpha-chymase
- alpha-galactosidase
- alpha-glucosidase
- alpha-mannosidase
- alpha-ttp
- alpha-tubulin
- alpha-xylosidase
- ck2- alpha
- cki-alpha
- dgk-alpha
- dgl-alpha
- err-alpha ITC
- ftase-alpha
- pkc-alpha
- ppar-alpha
- rar-alpha
- tap54-alpha
- thromboxane alpha
- thyroid alpha
- tnf-alpha
- casein kinase ii subunit alpha alpha beta beta
- neuronal acetylcholine receptor subunit alpha-10/alpha-9
- retinoic acid receptor alpha/retinoid x receptor alpha
- ribosomal protein s6 kinase alpha-1/alpha-3
- alpha-2a adrenergic receptor [16-465]/alpha-2b adrenergic receptor/alpha-2c adrenergic receptor
- hypoxia inducible factors; hif-1-alpha, hif-2-alpha
- neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit
- nicotinic acetylcholine receptor alpha-3/beta-4/alpha-5
- oxysterols receptor lxr-alpha/retinoic acid receptor rxr-alpha
- retinoic acid receptor rxr-alpha/thyroid hormone receptor alpha
- aldose reductase (alr2) mutant (l300p)
- bira bifunctional protein mutant (v214a)
- bira bifunctional protein mutant (v219a)
- bira bifunctional protein mutant (w223a)
- carbonic anhydrase ii mutant (f130v)
- dihydrofolate reductase (dhfr) mutant (f98y)
- dihydrofolate reductase (dhfr) mutant (i100l)
- dihydroorotate dehydrogenase (dhodh) mutant (h185a)
- dihydroorotate dehydrogenase (dhodh) mutant (r265a)
- dna-pk/ src mutant (t338i)
- hcv ns5b polymerase mutant (p495a)
- hcv ns5b polymerase mutant (r501e)
- hiv-1 protease mutant (a71v)
- hiv-1 protease mutant (d30n)
- hiv-1 protease mutant (g73s)
- hiv-1 protease mutant (i47l)
- hiv-1 protease mutant (i50l)
- hiv-1 protease mutant (i50v)
- hiv-1 protease mutant (i84v)
- hiv-1 protease mutant (l23i)
- hiv-1 protease mutant (l23v)
- hiv-1 protease mutant (l76m)
- hiv-1 protease mutant (v32i)
- hiv-1 protease mutant (v82a)
- hiv-1 protease mutant (v82i)
- hiv-1 protease triple mutant
- hyhel-10 fv mutant (hd32a)
- hyhel-10 fv mutant (hd32e)
- hyhel-10 fv mutant (hd32n)
- isocitrate dehydrogenase 2 mutant (r172s)
- p110-delta/ src mutant (t338i)
- transcriptional regulator ttgr mutant r176g
- tyrosine kinase flt3 mutant (d835h)
- tyrosine kinase flt3 mutant (d835y)
- 20-alpha-hsd
- adrenergic receptor alpha
- alpha 1a-adrenoreceptor
- alpha 1b-adrenoceptor
- alpha 2a adrenoceptor
- alpha carbonic anhydrase
- alpha-1-antichymotrypsin
- alpha-1-antiproteinase
- alpha-1a adrenoceptor
- alpha-2,3-sialyltransferase
- alpha-2-m
- alpha-2a adrenoreceptor
- alpha-2b adrenoreceptor
- alpha-amylase 1a
- alpha-carbonic anhydrase
- alpha-elapitoxin-nk2a
- alpha-galactosidase a
- alpha-l-iduronidase
- alpha-mannosidase 2
- alpha-mannosidase 2c1
- alpha-trehalose glucohydrolase
- cgk 1 alpha
- crf-r2 alpha
- dna polymerase alpha
- dnase ii alpha
- estrogen receptor alpha
- gh92 alpha-mannosidase
- hpαca
- inhibin alpha chain
- integrin alpha-4
- n-alpha 2
- pancreatic alpha-amylase
- pgf2 alpha receptor
- pgf2-alpha receptor
- pi3k-alpha/ ephb4
- pi3k-alpha/ hck
- pi3k-alpha/ mtor
- pi3k-alpha/ src
- pi3k-alpha/ vegfr2
- pkc alpha [mouse]
- ppar alpha/gamma
- putative alpha-glucosidase
- rac-pk-alpha
- tnf-alpha convertase
- tubulin alpha chain
- urease subunit alpha
- (1->4)-alpha-d-glucan:maltose-1-phosphate alpha-d-maltosyltransferase
- neuronal acetylcholine receptor subunit alpha-3/alpha-5/beta-4
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4
- phosphatidylinositol 3-kinase 85 kda regulatory subunit alpha (pi3k alpha)
- guanine nucleotide-binding protein g(q) subunit alpha/subunit alpha-11
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pi3k alpha)
- b-raf protein kinase mutant (v599e)
- cytochrome p450 51(cyp51) mutant (f78l)
- egf-r tyrosine kinase mutant (g719c)
- egf-r tyrosine kinase mutant (g719s)
- egf-r tyrosine kinase mutant (l858r)
- egf-r tyrosine kinase mutant (t790m)
- enoyl-acp reductase (fabi) mutant (f203l)
- hiv-1 protease mutant (d30n/a71v)
- hiv-1 protease mutant (d30n/m36i)
- hiv-1 protease mutant (l10i/l90m)
- hiv-1 protease mutant (m36i/a71v)
- hiv-1 protease mutant (m46i/i54v)
- hiv-1 protease mutant (v82a/i84v)
- hiv-1 protease mutant (v82f/i84v)
- hiv-1 protease mutant k-60c
- hiv-1 protease mutant v-18c
- hiv-1 protease mutant, a-1
- hiv-1 protease mutant, mdr-hm
- hiv-1 protease mutant, mdr-qm
- hiv-1 protease mutant, nam-10
- hiv-1 reverse transcriptase mutant (k103n)
- hiv-1 reverse transcriptase mutant (l100i)
- hiv-1 reverse transcriptase mutant (p236l)
- hiv-1 reverse transcriptase mutant (v106a)
- hiv-1 reverse transcriptase mutant (v179d)
- hiv-1 reverse transcriptase mutant (y181c)
- hiv-1 reverse transcriptase mutant (y188l)
- leucyl-trna synthetase k510e mutant (k510e)
- nitric oxide synthase mutant (enos y477a)
- nitric oxide synthase mutant (nnos h341l)
- nitric oxide synthase, brain mutant (d597n)
- nitric oxide synthase, endothelial mutant (n368d)
- pfdhfr-ts double mutant (c59r+s108n)
- pretherapy isolated ae protease mutant (v82f)
- tyrosine kinase c-met mutant (d1228h)
- 14-alpha sterol demethylase
- 20 alpha-hydroxysteroid dehydrogenase
- 3-alpha hydroxysteroid dehydrogenase
- 4-ph alpha-1
- acetylcholine receptor subunit alpha
- adrenergic receptor alpha-1
- adrenergic receptor alpha-2
- adrenergic receptors (alpha 2)
- adrenergic, alpha-2c-, receptor
- alpha 2b adrenergic receptor
- alpha-(1,3)-fucosyltransferase 10
- alpha-(1,3)-fucosyltransferase iv
- alpha-(2,3)-(n)-sialyltransferase
- alpha-1 adrenergic receptor
- alpha-1,2-mannosidase, putative
- alpha-1a adrenergic receptor
- alpha-1b adrenergic receptor
- alpha-1c adrenergic receptor
- alpha-1d adrenergic receptor
- alpha-2 adrenergic receptor
- alpha-2a adrenergic receptor
- alpha-2b adrenergic receptor
- alpha-2d adrenergic receptor
- alpha-bungarotoxin isoform a31
- alpha-fucosidase-like protein
- alpha-glucosidase (α-glucosidase)
- alpha-l-fucosidase i
- alpha-l-fucoside fucohydrolase
- beta-hexosaminidase subunit alpha
- caax farnesyltransferase alpha subunit
- cam kinase i alpha
- cam kinase ii alpha
- carbonic anhydrase, alpha family
- ck ii subunit alpha
- cng channel alpha-2
- diacylglycerol kinase alpha/zeta
- ef-1-alpha-2
- estrogen receptor (er alpha)
- estrogen receptor alpha d538g
- fibronectin receptor subunit alpha
- glucan 1,4-alpha-glucosidase
- golgi alpha-mannosidase ii
- gsk-3 alpha/beta
- integrin alpha-4/beta7
- kynurenine/alpha-aminoadipate aminotransferase
- lanosterol 14-alpha demethylase
- lanosterol 14-alpha-demethylase
- liver x receptor alpha
- lymphocyte alpha-protein kinase
- lysosomal acid alpha-mannosidase
- mannosidase 2 alpha 1
- mannosidase 2, alpha b1
- map kinase p38 alpha
- mip-1 alpha receptor
- neutral alpha-glucosidase c
- nuclear receptor ror-alpha
- p110-delta/ p110-alpha
- peptidylglycine alpha-amidating monooxygenase
- pi3k-alpha/ dna-pk
- pi3k-alpha/ p110-gamma
- plasma alpha-l-fucosidase
- pld alpha c2 domain
- probable alpha-glucosidase os06g0675700
- prostaglandin f2-alpha receptor
- protein kinase c, alpha
- protein-tyrosine phosphatase alpha
- retinoic acid receptor alpha
- retinoid x receptor alpha
- rna polymerase subunit alpha
- sodium channel alpha subunit
- steroid 17-alpha-monooxygenase
- steroid 5-alpha-reductase
- sterol 14-alpha demethylase
- thyroid hormone receptor alpha
- tissue alpha-l-fucosidase
- tnf-alpha-converting enzyme
- tropomyosin alpha-1 chain
- tubulin alpha-1a chain
- vla-2 alpha chain
- vla-2 subunit alpha
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-2/beta-3
- isoform alpha-4-2 of neuronal acetylcholine receptor subunit alpha-4 (alpha-4-2)/neuronal acetylcholine receptor subunit beta-2
- camp-dependent protein kinase (pka) mutant (e127d)
- cyclin-dependent kinase 2 (cdk2) mutant (f82h)
- cyclin-dependent kinase 2 (cdk2) mutant (k89t)
- cystic fibrosis transmembrane conductance regulator mutant g550e
- hiv-1 protease b subtype mutant (v82f)
- hiv-1 protease drug-resistant mutant 1
- hiv-1 protease mutant (a71v/v82t/i84v)
- hiv-1 reverse transcriptase mutant (103n/181c)
- hiv-1 reverse transcriptase mutant (l100i/k103n)
- protein-tyrosine phosphatase 1b (ptp1b) mutant (g117e)
- protein-tyrosine phosphatase 1b (ptp1b) mutant (l119v)
- protein-tyrosine phosphatase 1b (ptp1b) mutant (m114v)
- src homology 2 domain mutant (sh2-58.6)
- tyrosine kinase c-kit mutant (v559d/t670i)
- isoform alpha-1 of mitogen-activated protein kinase 10 (alpha-1) 9-402]
- 1,4-alpha-d-glucan glucanohydrolase
- 1,4-alpha-d-glucan glucohydrolase
- 25-ohd-1 alpha-hydroxylase
- acetylcholine receptor protein alpha chain
- alpha-amylase type a isozyme
- alpha-enolase/huntingtin [1-89]
- beta-hexosaminidase subunit alpha (hexa)
- beta-hexosaminidase subunit alpha/beta
- beta-n-acetylhexosaminidase subunit alpha
- cam kinase ii alpha/beta
- casein kinase ii alpha (prime)
- casein kinase ii alpha''''/ beta
- casein kinase ii subunit alpha
- caspase-9 isoform alpha preproprotein
- cerebral cortex alpha adrenergic receptor
- cholinergic receptor, nicotinic alpha 1
- collagen alpha-1(ii) chain
- diacylglycerol kinase alpha [9-727]
- dna polymerase (alpha/delta/epsilon)
- dna polymerase alpha catalytic subunit
- dna polymerase iii subunit alpha
- g-protein subunit alpha-11
- g-protein subunit alpha-16
- gaba receptor alpha-1 subunit
- gaba receptor alpha-2 subunit
- gaba receptor alpha-5 subunit
- gaba receptor alpha-6 subunit
- galnac alpha-2,6-sialyltransferase iii
- glycine receptor (alpha-1/beta)
- glycine receptor alpha-3/beta
- glycine receptor alpha-4 chain
- glycine receptor subunit alpha-1
- glycine receptor subunit alpha-2
- glycine receptor subunit alpha-3
- histamine h2-gs alpha s
- hypoxia-inducible factor 1-alpha
- integrin alpha m/beta-2
- integrin alpha-1/beta-1
- integrin alpha-2/beta-3
- integrin alpha-3/beta-3
- integrin alpha-4/beta-1
- integrin alpha-4/beta-7
- integrin alpha-5/beta-1
- integrin alpha-5/beta-6
- integrin alpha-5/beta-8
- integrin alpha-iib/beta-3
- integrin alpha-v/beta-3
- integrin alpha-v/beta-5
- interleukin-2 receptor alpha chain
- interleukin-5 receptor subunit alpha
- liver x receptor alpha (lxra)
- lung alpha/beta hydrolase 2
- n-acetyllactosaminide alpha-1,3-galactosyltransferase
- oncostatin-m receptor subunit alpha
- p38 map kinase alpha/beta
- p450 sterol 14-alpha-demethylase
- peroxisome proliferator activated receptor alpha
- peroxisome proliferator-activated receptor alpha
- phosphatidylinositol 4-kinase alpha (pi4ka)
- phosphoinositide 3-kinase (pi3k), alpha
- pi3-kinase p110-alpha subunit
- pkc alpha and beta-2
- protein kinase c alpha type
- retinoic acid receptor rxr-alpha
- retinoic acid receptors gamma / alpha
- retinoid-related orphan receptor-alpha
- steroid 5-alpha-reductase 1
- steroid 5-alpha-reductase 2
- sterol 14-alpha demethylase (cyp51)
- sterol 14-alpha demethylase cyp51a
- thyroid hormone receptor (tr-alpha)
- tryptophan synthase alpha /beta chains
- tubulin alpha chain /beta chain
- tubulin alpha-1a/beta chain
- tumor necrosis factor alpha (tnf)
- urease subunit alpha/beta/gamma
- n-type calcium channel subunits alpha 1b (cav2.2), beta 3, and alpha 2 delta
- phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- camp-dependent protein kinase (pka) mutant (l49i/t183a)
- camp-dependent protein kinase (pka) mutant (q181k/t183a)
- camp-dependent protein kinase (pka) mutant pkar1 (3)
- dihydrofolate reductase-thymidylate synthase (dhfr-ts) mutant kicb1
- hiv-1 protease a subtype mutant (v82f/i84v)
- hiv-1 protease b subtype mutant (v82f/i84v)
- hiv-1 protease c subtype mutant (v82f/i84v)
- hiv-1 protease mutant v6(46/54/84)
- hiv-1 reverse transcriptase rnase h mutant (y181c)
- hiv-1 reverse transcriptase rnase h mutant (y188l)
- mitogen-activated protein kinase 9 (jnk2) mutant (c162s)
- mitogen-activated protein kinase 9 (jnk2) mutant (r127a)
- monoamine oxidase type b (mao-b) mutant (i199f)
- phosphodiesterase type 5 (pde5a) h-loop deletion mutant
- protein-tyrosine phosphatase 1b (ptp1b) mutant (v113l/m114v)
- proto-oncogene tyrosine-protein kinase abl1 mutant f359v
- proto-oncogene tyrosine-protein kinase abl1 mutant q252h
- src homology 2 domain mutant (t40v/c45a/k60l)
- tyrosine kinase csf1-r mutant (tie2 kid chimera)
- tyrosyl-dna phosphodiesterase 2 mutant 9m(mtdp2 9m)
alpha,alpha'-dipyridyl 2-(2-pyridyl)pyridine bpy alpha,alpha'-bipyridyl 2,2'-Bipyridin 2,2'-bipyridyl US10196346, Bipyridine 2,2'-dipyridine 2,2'-bipyridine alpha,alpha'-bipyridine alpha,alpha'-dipyridine BDBM50042874 CHEMBL39879 2,2'-dipyridyl
(-)-ALPHA-BISABOLOL BDBM50382730 ALPHA-BISABOLOL
US9259470, Alpha US8697715, Alpha BDBM120126
(1S)-1-phenylethanamine BDBM50028638 L-(-)-alpha-phenylethylamine L(-)-alpha-methylbenzylamine (alphaS)-alpha-methylbenzenemethanamine (S)-alpha-methylbenzenemethanamine CHEMBL282700 (S)-(-)-alpha-methylbenzylamine L-alpha-methylbenzylamine L-(-)-1-phenylethylamine (-)-alpha-phenethylamine
Alpha, alpha-dimethyl derivative, 5 BDBM82120
2-alpha-11-alpha-dihydroxyfawcettidine BDBM50213090 CHEMBL376327
Alpha-Tocopheryl Succinate (+)-ALPHA-TOCOPHERYL SUCCINATE BDBM50458511
(R)-alpha-methoxy-alpha-trifluoromethyl phenylacetic acid BDBM36091
ALPHA-MSH CAS_10466-28-1 alpha MSH BDBM82412
BDBM36092 (S)-alpha-methoxy-alpha-trifluoromethyl phenylacetic acid
CHEMBL1398 Alpha-Phenyl-Gamma-Butyrolactone alpha-phenylbutyrolactone BDBM50180937
CHEMBL216458 alpha-bungarotoxin BDBM50121739 Bungarotoxin Neuronal Bungarotoxin,Alpha
TMPNPNPthymidine 5'-[alpha,beta:beta,alpha-diimido]triphosphate BDBM50002467
CHEMBL486197 BDBM50241894 gorgostane-3-beta,9-alpha,5-alpha,6-beta,11-alpha-tetrol
D-alpha-methylbenzylamine BDBM50028628 CHEMBL19969 (alphaR)-alpha-methylbenzenemethanamine (R)-alpha-methylbenzenemethanamine (1R)-1-phenylethanamine
1-phenylethanamine 1-phenylethylamine CHEMBL278059 alpha-Methylbenzylamine BDBM50023171 alpha-Phenylethylamine 1-amino-1-phenylethane 1-phenethylamine alpha-methylbenzenemethanamine alpha-aminoethylbenzene
BDBM50014945 alpha-methyl-5-hydroxytryptamine CHEMBL275854 alpha-methyl-5-HT alpha-methylserotonin 3-(2-aminopropyl)-1H-indol-5-ol alpha-M-5-HT
BDBM50378887 ALPHA-CONIDENDRIN
BDBM50470946 Alpha-Hydroxytrimethoprim
BDBM93095 Alpha-Phenylguanidine
alpha-ddCHA BDBM82067
Alpha-Methylhistane-R CHEMBL268229 R-alpha-methylhistamine (2R)-1-(1H-imidazol-5-yl)propan-2-amine Alpha-Methylhistamine-R RAMH BDBM22904 (R)-alpha-Methylhistamine
methyl phenidylacetate BDBM50062912 methyl alpha-phenyl-alpha-(2-piperidyl)acetate alpha-phenyl-2-piperidineacetic acid methyl ester methyl phenyl(piperidin-2-yl)acetate methylphenidan methyl alpha-phenyl-alpha-2-piperidinylacetate CHEMBL796 Methylphenidate
(R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE Alpha-Methylhistamine-R CAS_75614-87-8 BDBM81973
alpha-oxobutyrate 2-oxobutanate 2-oxobutanoate BDBM50273975 2-ketobutyrate alpha-ketobutyrate
PTHRct-8 mutant (QAEWETVM) QAEWETVM BDBM228841
QAAWETVM PTHRct-8 mutant (QAAWETVM) BDBM228843
QEAWETVM PTHRct-8 mutant (QEAWETVM) BDBM228842
QEEWATVM PTHRct-8 mutant (QEEWATVM) BDBM228844
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide CHEMBL517 DISOPYRAMIDE gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide BDBM50028893 alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide
ALPHA-HYDRAZINE ORNITHINE BDBM50487428
Alpha-Tocopherylquinone BDBM50041386 CHEMBL1223852
Alpha-ureidophosphonate, a BDBM86793
Alpha-ureidophosphonate, d BDBM86795
Alpha-ureidophosphonate, e BDBM86796
Alpha-ureidophosphonate, g BDBM86797
Alpha-ureidophosphonate, k BDBM86799
BDBM22903 N(alpha)-Methylhistamine
BDBM50194425 CHEMBL218788 alpha-cyclocostunolide
BDBM50252405 Pifithrin-Alpha CHEMBL556353
BDBM50305202 CHEMBL589873 alpha-Methylcinnamaldoxime
BDBM50531261 alpha-amyrenone CHEMBL518475
BDBM82406 desacetyl-alpha-MSH
BDBM85022 alpha-MSH, [Nle4]
BDBM85837 h alpha-CGRP
BDBM86794 Alpha-ureidophosphonate, b
BDBM86798 Alpha-ureidophosphonate, i
CHEMBL198759 BDBM50478353 Pifithrin-Alpha
CHEMBL520915 alpha-methylcubebin BDBM50259857
alpha-Phenylbutyrolactone CHEMBL380124 BDBM50180939
alpha-benzoyloxypaeoniflorin BDBM50310714 CHEMBL1079225
alpha-rhamnoisorobin CHEMBL1289337 BDBM50331857
BDBM50156923 CHEMBL221993 (1R)-3-alpha-(4-methylphenyl)tropane-2-alpha-carboxylic acid
BDBM50177106 2-beta-3-beta-diphenyltropane CHEMBL388850 2-alpha-3-alpha-diphenyltropane
BDBM50208825 (+)-3,4,3',4'-tetrahydroxy-9,7'alpha-epoxylignano-7 alpha,9'-lactone CHEMBL227135
CHEMBL374712 BDBM50156921 (1R)-3-alpha-(4-chlorophenyl)tropane-2-alpha-carboxylic acid
CHEMBL571174 BDBM50301393 1-[4-(4-methylcyclohexyl)butyl]alpha,alpha-diphenyl-4-piperdinemethanol
alpha,alpha-Dimethylphenethylamine 2-methyl-1-phenylpropan-2-amine CHEMBL1574 BDBM50246598 PHENTERMINE
(2R)-amino(phenyl)acetic acid D-alpha-phenylglycine D-(-)-alpha-Phenylglycine BDBM50179720 CHEMBL1403
17-cyclopropylmethyl-3,14-beta-dihydroxy-4,5-alpha-epoxy-6-alpha-(benzamido)morphinan BDBM86942
3 ALPHA-HYDROXY-7 ALPHA-FLUORO-5 BETA-CHOLAN-24-OIC A BDBM50375555
BDBM50301391 1-[4-(4-methylphenyl)butyl]-alpha,alpha-diphenyl-4-piperdine-methanol CHEMBL571389
uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] UDP-alpha-D-glucose BDBM50209659
CHEMBL578629 BDBM50300442 (20R)-4,5-alpha-Epoxy-17-methyl-3-hydroxy-6-methoxy-alpha-17-dimethyl-alpha-(2-phenylethyl)-6,14-ethenomorphinan-7-methanol
(R)-alpha-methoxyphenylacetic acid BDBM36089
(S)-alpha-methoxyphenylacetic acid BDBM36090
7 alpha-Spirobenzocyclohexylhydromorphone CHEMBL318361 BDBM50059992
7 alpha-Spirobenzocyclohexyloxymorphone BDBM50059990 CHEMBL318598
BDBM220119 US9271961, alpha-Mehtylcinnamic acid
BDBM36009 L-alpha-o-benzylglycerol
BDBM50059994 CHEMBL105081 7 alpha-Spirobenzocyclohexylnaltrexone
BDBM50288610 Alpha-ketocarbonyl derivative CHEMBL98937
BDBM50472559 (S)-Alpha-Methylhistamine CHEMBL11919
BDBM641071 US20230399418, Compound alpha-Methylfentanyl
BDBM85130 14-alpha-triptolide, 7
BDBM86517 5-(GSyl)-alpha-MethylDopamine
CHEMBL1084541 BDBM50318914 (+/-)-alpha-tocopherol nicotinate
CHEMBL1084610 Hydroxy-alpha-sanshool BDBM50318477
CHEMBL1170424 BDBM50322610 alpha-Sulfanylbenzylphosphonic acid
CHEMBL317337 Alpha-ketocarbonyl derivative BDBM50288609
[Pro14]h alpha-CGRP BDBM85834
alpha-Sulfanylpropylphosphonic acid CHEMBL1172388 BDBM50322608
alpha-ketoamide inhibitor 13a BDBM420293
CHEMBL425373 [ alpha-Neu5Ac-(2,3)-beta-D-Gal-(1,4) (alpha-Fuc-(1,3))-D-Glc ] BDBM50168310
N-alpha-methylhistamine N-methylhistamine [3H]N-alpha-methyl histamine BDBM22530 NAMH N(alpha)-Methylhistamine [2-(1H-imidazol-5-yl)ethyl](methyl)amine
- Tu, Z; Kotzbauer, PT; Yue, X; Dhavale, DD Alpha-synuclein ligands US Patent US12012394 (2024)
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- ChEMBL_2281070 Inhibition of alpha-Synuclein (unknown origin)
- ChEMBL_2295415 Inhibition of Alpha-synuclein (unknown origin) fibrils
- ChEMBL_2277651 Binding affinity to human brain alpha-synuclein fibril
- ChEMBL_2295411 Binding affinity to Alpha-synuclein (unknown origin) assessed as dissociation constant
- ChEMBL_2442952 Binding affinity to alpha-synuclein (unknown origin) assessed as dissociation constant
- ChEMBL_1994333 (CHEMBL4628228) Binding affinity to human wlid-type alpha-synuclein by SPR analysis
- ChEMBL_2295414 Binding affinity to Alpha-synuclein (unknown origin) fibrils assessed as inhibition constant
- ChEMBL_1834277 (CHEMBL4334285) Inhibition of alpha-synuclein (unknown origin) self-aggregation by fluorescence polarization assay
- ChEMBL_2295410 Binding affinity to human recombinant Alpha-synuclein assessed as dissociation constant by fluorometric method
- ChEMBL_2315362 Binding affinity to biotinylated recombinant alpha-synuclein (unknown origin) assessed as dissociation constant by BLI assay
- ChEMBL_2320669 Inhibition of alpha-Synuclein (unknown origin) aggregation incubated for 72 hrs by ThT-based fluorescence analysis
- ChEMBL_2440499 Binding affinity to Alpha-synuclein (unknown origin) preformed fibrils assessed as dissociation constant by FP assay
- ChEMBL_2468944 Induction of his-tagged human alpha-Synuclein fibril depolymerization measured for 1 day by ThT fluorescence assay
- ChEMBL_1991810 (CHEMBL4625545) Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assay
- ChEMBL_2045851 (CHEMBL4700550) Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay
- ChEMBL_2045872 (CHEMBL4700571) Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS by fluorescence method
- ChEMBL_2045873 (CHEMBL4700572) Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) by circular dichroism analysis
- ChEMBL_2295413 Binding affinity to human recombinant Alpha-synuclein expressed in Escherichia coli assessed as dissociation constant at 200 uM
- ChEMBL_2448617 Inhibition of wild type full length recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli by spectrophotometric analysis
- ChEMBL_1505263 (CHEMBL3594888) Binding affinity to recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1 hr by scintillation counting
- ChEMBL_2045854 (CHEMBL4700553) Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 6 days by thioflavin S based fluorescence assay
- ChEMBL_2045865 (CHEMBL4700564) Binding affinity to human alpha-synuclein (1 to 140 residues) expressed in Escherichia coli by isothermal titration calorimetry
- ChEMBL_2328649 Inhibition of recombinant human Alpha-synuclein aggregation expressed in Escherichia coli incubated for 72 hrs by ThT fluorescence assay
- ChEMBL_1505256 (CHEMBL3594881) Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay
- ChEMBL_2479224 Inhibition of alpha-Synuclein (unknown origin) aggregation assessed as aggregation inhibition ratio incubated for 72 hrs by Thioflavin T fluorescence assay
- ChEMBL_2045853 (CHEMBL4700552) Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay
- ChEMBL_2045866 (CHEMBL4700565) Inhibition of wild type human alpha-synuclein fibrillization expressed in Escherichia coli BL21(DE3)pLysS by thioflavin-T based fluorescence assay
- ChEMBL_2475603 Inhibition of alpha-Synuclein (unknown origin) aggregation assessed as aggregation inhibition ratio measured after 72 hrs by Thioflavin T based fluorescence assay
- ChEMBL_831727 (CHEMBL2065090) Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay
- ChEMBL_1842065 (CHEMBL4342364) Inhibition of alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 days by thioflavin T fluorescence assay
- ChEMBL_2045858 (CHEMBL4700557) Binding affinity to alpha-synuclein oligomer (unknown origin) expressed in Escherichia coli BL21(DE3) cells incubated for 30 mins by spectrofluorometric analysis
- ChEMBL_2045857 (CHEMBL4700556) Binding affinity to alpha-synuclein preformed fibrils (unknown origin) expressed in Escherichia coli BL21(DE3) cells incubated for 30 mins by spectrofluorometric analysis
- ChEMBL_2045874 (CHEMBL4700573) Binding affinity to human alpha-synuclein (1-140 residues) expressed in Escherichia coli BL21(DE3) assessed as first dissociation constant by mass-spectrometry
- ChEMBL_2045875 (CHEMBL4700574) Binding affinity to human alpha-synuclein (1-140 residues) expressed in Escherichia coli BL21(DE3) assessed as second dissociation constant by mass-spectrometry
- ChEMBL_2379496 Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluorescence microplate reader analysis
- ChEMBL_971423 (CHEMBL2406136) Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by ELISA
- ChEMBL_1781004 (CHEMBL4252521) Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by thioflavin T staining-based spectrofluorimetric analysis
- ChEMBL_2045852 (CHEMBL4700551) Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay
- ChEMBL_2045859 (CHEMBL4700558) Binding affinity to alpha-synuclein LMV 100 kDa (unknown origin) expressed in Escherichia coli BL21(DE3) cells incubated for 30 mins by spectrofluorometric analysis
- ChEMBL_2045860 (CHEMBL4700559) Binding affinity to alpha-synuclein LMV 50 kDa (unknown origin) expressed in Escherichia coli BL21(DE3) cells incubated for 30 mins by spectrofluorometric analysis
- ChEBML_33815 Concentration required to inhibit the mutant alpha-Ala HCMV protease by 50% was determined
- ChEMBL_2045855 (CHEMBL4700554) Inhibition of wild type alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 cells incubated for 30 days by thioflavin T based fluorescence assay
- ChEMBL_2295416 Binding affinity to C-terminal His6-tagged human Alpha-synuclein fibrils (1 to 97 residues) expressed in Escherichia coli assessed as dissociation constant by chromatography method
- ChEMBL_2428851 Inhibition of alpha-synuclein (unknown origin) aggregation inhibition ratio by measuring relative fluorescence intensity measured after 3 days by ThT F1 based assay relative to control
- ChEMBL_2267524 Binding affinity to human beta catenin double mutant assessed as dissociation constant by alpha assay
- ChEMBL_330377 (CHEMBL870612) Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cells
- ChEMBL_330378 (CHEMBL870611) Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cells
- ChEMBL_330379 (CHEMBL853031) Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cells
- ChEMBL_330380 (CHEMBL853032) Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cells
- ChEMBL_330381 (CHEMBL853033) Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cells
- ChEMBL_330382 (CHEMBL853034) Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cells
- ChEMBL_330383 (CHEMBL853035) Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cells
- ChEMBL_330384 (CHEMBL853036) Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cells
- ChEMBL_330385 (CHEMBL853037) Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cells
- ChEMBL_430501 (CHEMBL917750) Displacement of [125I]NDP-alpha-MSH from MC4R D122A mutant expressed in HEK293 cells
- ChEMBL_2211422 (CHEMBL5124371) Inhibition of alpha-Synuclein (unknown origin) aggregation assessed as aggregation inhibitory ratio by measuring relative fluorescence intensity and measured after 72 hrs by ThT flourescence assay
- ChEMBL_1543930 (CHEMBL3750038) Inhibition of human recombinant PLK1 using recombinant dephosphorylated bovine alpha- casein/synuclein as substrate after 30 mins by scintillation counting analysis in presence of gamma-32P-ATP
- ChEMBL_1543931 (CHEMBL3750039) Inhibition of human recombinant PLK3 using recombinant dephosphorylated bovine alpha- casein/synuclein as substrate after 30 mins by scintillation counting analysis in presence of gamma-32P-ATP
- ChEMBL_1543932 (CHEMBL3750040) Inhibition of human recombinant PLK4 using recombinant dephosphorylated bovine alpha- casein/synuclein as substrate after 30 mins by scintillation counting analysis in presence of gamma-32P-ATP
- ChEMBL_1809927 (CHEMBL4309387) Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 mins
- ChEBML_153380 Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells
- ChEMBL_2333292 Binding affinity to recombinant alpha-synuclein preformed fibrils (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant incubated for 10 min by spectrophotometry based fluorescence polarization analysis
- ChEMBL_153379 (CHEMBL882312) Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells
- ChEMBL_153380 (CHEMBL763566) Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells
- ChEMBL_1720748 (CHEMBL4135748) Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysis
- ChEMBL_1809902 (CHEMBL4309362) Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG after 105 mins by NADPH depletion assay
- ChEMBL_1809903 (CHEMBL4309363) Inhibition of IDH1 R132C mutant (unknown origin) using alpha-KG after 105 mins by NADPH depletion assay
- ChEMBL_217784 (CHEMBL824045) Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gamma2 subunits expressed in HEK293 cells
- ChEMBL_217785 (CHEMBL824046) Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gamma2 subunits expressed in HEK293 cells
- ChEMBL_2495635 Inhibition of human IDH1 R132H mutant heterodimer in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assay
- ChEMBL_1720749 (CHEMBL4135749) Inhibition of IDH1 R132H mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assay
- ChEMBL_1720751 (CHEMBL4135751) Inhibition of IDH1 R132C mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assay
- ChEMBL_1764686 (CHEMBL4199933) Inhibition of IDH1 R132H mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assay
- ChEMBL_1764687 (CHEMBL4199934) Inhibition of IDH1 R132C mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assay
- ChEMBL_1809897 (CHEMBL4309357) Inhibition of IDH1 R132C mutant (unknown origin) using alpha-KG as substrate after 60 mins by resazurin based assay
- ChEMBL_217786 (CHEMBL824047) Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gamma2 subunits expressed in HEK293 cells
- ChEMBL_2027536 (CHEMBL4681694) Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate and NADPH incubated for 30 mins by fluorescence based assay
- ChEMBL_2027537 (CHEMBL4681695) Inhibition of IDH1 R132C mutant (unknown origin) using alpha-ketoglutarate and NADPH incubated for 30 mins by fluorescence based assay
- ChEMBL_217122 (CHEMBL822942) Binding affinity for mutant rat GABA-A receptor alpha-1-(arg)-beta-2-gamma-2 subunits expressed in HEK293 cells
- ChEMBL_217123 (CHEMBL822943) Binding affinity for mutant rat GABA-A receptor alpha-1-(arg)-beta-2-gamma-2 subunits expressed in HEK293 cells
- ChEMBL_217782 (CHEMBL824043) Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells
- ChEMBL_217783 (CHEMBL824044) Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells
- ChEMBL_217787 (CHEMBL824048) Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gamma2 subunits expressed in HEK293 cells
- ChEMBL_217788 (CHEMBL824049) Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gamma2 subunits expressed in HEK293 cells
- ChEMBL_2495642 Inhibition of wildtype human recombinant IDH1 R132H mutant heterodimer in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assay
- ChEMBL_2520282 Binding affinity to p110 alpha E542K mutant (unknown origin) assessed as inhibition constant in presence of ATP by TR-FRET assay
- ChEMBL_2520283 Binding affinity to p110 alpha E545K mutant (unknown origin) assessed as inhibition constant in presence of ATP by TR-FRET assay
- ChEMBL_2520284 Binding affinity to p110 alpha H1047R mutant (unknown origin) assessed as inhibition constant in presence of ATP by TR-FRET assay
- ChEMBL_2337015 Inhibition of wildtype alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 (DE3) cells assessed as decrease in relative fluorescence intensity incubated for 72 hrs by ThT dye based fluorescence spectrophotometric analysis relative to control
- ChEMBL_405876 (CHEMBL909175) Inhibition of mutant HIV1 integrase C130A mutant 3' processing step
- ChEMBL_1463321 (CHEMBL3399548) Inhibition of HIV1 reverse transcriptase L100I mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463322 (CHEMBL3399549) Inhibition of HIV1 reverse transcriptase K103N mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463323 (CHEMBL3399550) Inhibition of HIV1 reverse transcriptase V106A mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463324 (CHEMBL3399551) Inhibition of HIV1 reverse transcriptase Y181C mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463325 (CHEMBL3399552) Inhibition of HIV1 reverse transcriptase G190A mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1746166 (CHEMBL4180676) Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate after 60 mins by resazurin dye based fluorescence assay
- ChEMBL_1765951 (CHEMBL4201198) Induction of redissolving of aggregated alpha-crystallin A Y118D mutant (unknown origin) incubated for 24 hrs by ThT-fluorescence based assay
- ChEMBL_1765952 (CHEMBL4201199) Induction of redissolving of aggregated alpha-crystallin B R120G mutant (unknown origin) incubated for 24 hrs by ThT-fluorescence based assay
- ChEMBL_2300369 Inhibition of human wild type IDH1/IDH1 R132H mutant heterodimer in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assay
- ChEBML_215994 Inhibitory activity against alpha-chymotrypsin (alpha-CT)
- ChEMBL_1463326 (CHEMBL3399553) Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_2430964 Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated in presence of NADPH by Envision multimode plate reader analysis
- ChEMBL_2430965 Inhibition of IDH2 R172K mutant (unknown origin) using alpha-ketoglutarate as substrate incubated in presence of NADPH by Envision multimode plate reader analysis
- ChEMBL_2495647 Inhibition of IDH1 R132H mutant (unknown origin) expressed in Escherichia coli in presence of alpha-KG and NADPH by fluorescence based biochemical assay
- ChEBML_67839 Binding to Estrogen receptor- alpha (ER alpha) receptor
- ChEMBL_1510692 (CHEMBL3606178) Binding affinity to recombinant human IDH1 R132H mutant expressed in Escherichia coli by isothermal titration calorimetric analysis in presence of NADPH, alpha-KG
- ChEMBL_1797942 (CHEMBL4270059) Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using alpha-KG by succinate-glo demethylase assay
- ChEMBL_1809904 (CHEMBL4309364) Inhibition of IDH1 R132H mutant (unknown origin) expressed in HEK293T cells using alpha-KG in presence of NADPH by LC-MS/MS analysis
- ChEMBL_1809905 (CHEMBL4309365) Inhibition of IDH1 R132C mutant (unknown origin) expressed in HEK293T cells using alpha-KG in presence of NADPH by LC-MS/MS analysis
- ChEMBL_1809910 (CHEMBL4309370) Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-KG as substrate after 60 mins in presence of NADPH by resazurin-based assay
- ChEMBL_1809928 (CHEMBL4309388) Inhibition of IDH2 R172K mutant (unknown origin) using alpha-KG as substrate after 90 mins in presence of NADPH by RF/MS analysis
- ChEMBL_1809932 (CHEMBL4309392) Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate by by luminescence based assay
- ChEMBL_1496363 (CHEMBL3579967) Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry
- ChEMBL_2430959 Inhibition of recombinant IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 60 mins in presence of NADPH by fluorescence microplate reader
- ChEMBL_2430960 Inhibition of recombinant IDH1 R132C mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 60 mins in presence of NADPH by fluorescence microplate reader
- Alpha-Synuclein Competitive Binding Assay (A) Expression and purification of recombinant wild-type human α-synuclein: 0.5 mM IPTG was used to induce production of wild type human α-synuclein by bacteria transformed with a full-length α-synuclein expression plasmid. After shaking at 16° C. for 20 hours, cell pellet was resuspended in lysis buffer (10 mM Tris, 1 mM EGTA, 0.75 mM NaCl, 1 mM PMSF, pH 7.5) and lysed by sonication followed by centrifugation (6000 g, 30 min, 4° C.). The supernatant was then boiled at 95° C. for 15 min with manual agitation by every 5 minutes, followed by centrifugation (6000 g, 30 min, 4° C.). Supernatant was dialyzed with (10 mM Tris, 1 mM EGTA, 50 mM NaCl, pH 7.5) buffer and concentrated with concentrator. The collected sample was loaded onto a Superdex200 column, the flow-through fraction was then loaded onto a Q-HP column. Collected fractions with α-synuclein eluates were pooled, concentrated and stored at −80° C.(B) Preparation of aggregated α-synuclein: 5 mg/mL of α-synuclein in PBS buffer (pH 7.4) was incubated in tube with at 37° C. with shaking (700 rpm) for 5-10 days.(C) In vitro fluorometric α-synuclein binding assays: 2 μM α-synuclein was incubated with serially diluted compound (three-fold serial dilutions, from 10 to 0.001 μM) in a 96-well plate at 37° C. for 1 hour. Fluorescence intensity was read by microplate spectrometer. Compound Kd values were calculated using the following equation: Y=Bmax*X/(Kd+X), where X is the concentration of compound; Y is the fluorescence signal of (compound+α-synuclein)−(compound+DMSO); and Bmax is the maximum signal.
- ChEBML_153484 Binding affinity towards peroxisome proliferator activated receptor alpha (murinePPAR alpha)
- ChEBML_153546 Binding affinity towards peroxisome proliferator activated receptor alpha (PPAR alpha)
- ChEBML_153717 Binding affinity for Peroxisome proliferator activated receptor alpha (PPAR alpha)
- ChEMBL_160292 (CHEMBL769620) Affinity for protein kinase-C alpha (PK-C alpha)
- ChEMBL_197400 (CHEMBL799791) Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)
- ChEMBL_197401 (CHEMBL799792) Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)
- ChEMBL_197402 (CHEMBL799793) Binding affinity for Retinoic Acid Receptor alpha (RAR alpha).
- ChEMBL_216469 (CHEMBL818539) Inhibitory activity against bovine pancreatic alpha-chymotrypsin (alpha-CT)
- ChEMBL_67660 (CHEMBL673853) Binding affinity for Estrogen receptor alpha (ER alpha) receptor
- ChEMBL_1797935 (CHEMBL4270052) Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 10 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1797936 (CHEMBL4270053) Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 100 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1797937 (CHEMBL4270054) Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 1000 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1797941 (CHEMBL4270058) Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using alpha-KG measured immediately by succinate-glo demethylase assay
- ChEMBL_1829279 (CHEMBL4329153) Inhibition of IDH1 (unknown origin) R132H mutant using alpha-KG as substrate after 60 mins in presence of NADPH by resazurin dye-based fluorescence assay
- ChEMBL_2360520 Inhibition of IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2360526 Inhibition of IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2360528 Inhibition of IDH2 R172K mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2360529 Inhibition of IDH2 R140Q mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2495603 Inhibition of IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2495637 Inhibition of full length human recombinant IDH1 R132H mutant expressed in Escherichia coli assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2495638 Inhibition of full length human recombinant IDH1 R132C mutant expressed in Escherichia coli assessed as NADPH consumption using alpha-KG as substrate measured after 60 mins
- ChEMBL_2495644 Inhibition of human recombinant IDH1 R132H mutant expressed in Escherichia coli BL21 (DE3) cells in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assay
- ChEMBL_2495645 Inhibition of full length N-terminal GST-tagged human IDH1 R132H mutant expressed in Escherichia coli in presence of alpha-KG by fluorescence based biochemical assay
- ChEMBL_2024080 (CHEMBL4677893) Inhibition of N-terminal 6His-tagged/C-terminal Avi-tagged biotinylated GDP-bound human KRas G12D mutant (1 to 169 residues) assessed as reduction in KRas G12D mutant-SOS1 (564 to 1049 residues) protein-protein interaction by alpha screen assay
- ChEBML_32431 Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
- ChEMBL_153546 (CHEMBL766087) Binding affinity towards peroxisome proliferator activated receptor alpha (PPAR alpha)
- In Vitro Inhibition Assay α-Synucleinopathies are characterised by aggregation of α-synuclein in neurons. Aggregation of purified α-synuclein is performed essentially as described by Gerard et al. FASEB. 20(3):524-6 (2006). 20-100 μg purified α-synuclein (Sigma; S7820) at a concentration of about 2.5 μg/mL is incubated in the presence of spermin (250 μM) or paraquat (32 mM) or 6-hydroxydopamine (400 μM) or vehicle in a 384 well plate. Spermin, paraquat and 6-hydroxydopamine promote the α-synuclein aggregation process. Aggregation kinetics is determined by measuring turbidity at 340 nm, every 1-15 minutes for at least one hour.
- ChEMBL_2357243 Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 16 hrs in the presence of NADPH by absorbance based plate reader analysis
- ChEMBL_2357244 Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 1 hrs in the presence of NADPH by absorbance based plate reader analysis
- ChEMBL_2264767 Inhibition of FLT3 mutant (unknown origin)
- ChEMBL_2265574 Inhibition of mutant HTT (unknown origin)
- ChEMBL_2278144 Inhibition of human RET V804L mutant
- ChEMBL_2278145 Inhibition of human RET V804M mutant
- ChEMBL_2280927 Inhibition of human BRAF V600E mutant
- ChEMBL_2360427 Inhibition of human LRRK2 G2019S mutant
- ChEMBL_2360428 Inhibition of human LRRK2 I2020T mutant
- ChEMBL_2467729 Inhibition of human IDH1 R132H mutant
- ChEMBL_2495607 Inhibition of human IDH1 R132H mutant
- ChEMBL_382857 (CHEMBL869786) Inhibition of PTP1B V49A mutant
- ChEMBL_382858 (CHEMBL869785) Inhibition of PTP1B I219A mutant
- ChEMBL_382864 (CHEMBL869792) Inhibition of TCPTP I220A mutant
- ChEMBL_424220 (CHEMBL908994) Inhibition of Abl T315I mutant
- ChEMBL_459603 (CHEMBL925703) Inhibition of HIV1 protease mutant
- ChEMBL_501661 (CHEMBL981409) Inhibition of Abl T315I mutant
- ChEMBL_523244 (CHEMBL1000620) Inhibition of BRAF V600E mutant
- ChEMBL_617631 (CHEMBL1101240) Inhibition of BRAF V600E mutant
- ChEMBL_831688 (CHEMBL2065051) Inhibition of BRAF V600E mutant
- ChEMBL_2327368 Antagonist activity at ER-alpha (unknown origin) by ER-alpha coactivator assay
- ChEMBL_2327370 Agonist activity at ER-alpha (unknown origin) by ER-alpha coactivator assay
- ChEMBL_1797938 (CHEMBL4270055) Irreversible inhibition of 0.4 uM KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 100 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1797939 (CHEMBL4270056) Irreversible inhibition of 0.8 uM KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 100 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1797940 (CHEMBL4270057) Irreversible inhibition of 1.6 uM KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 100 uM alpha-KG by succinate-glo demethylase assay
- ChEMBL_1809914 (CHEMBL4309374) Inhibition of IDH2 R172K mutant (40 to end residues) (unknown origin) using alpha-KG as substrate after 120 mins in presence of NADPH by resazurin-based assay
- ChEMBL_2103885 (CHEMBL4812388) Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaphorase/resazurin-coupled system
- ChEMBL_2103887 (CHEMBL4812390) Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaphorase/resazurin-coupled system
- ChEMBL_2495643 Inhibition of human N-terminal 6His-tagged IDH1 R132C mutant expressed in Escherichia coli Rosetta2 (DE3) in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assay
- ChEMBL_2443862 Potentiation of CFTR N1303K mutant (unknown origin) expressed in FRT cells assessed as increase in CFTR mutant activity
- ChEBML_216617 Inhibition of alpha-chymotrypsin
- ChEBML_153472 In vitro transcription activation on human peroxisome proliferator activated receptor-alpha (PPAR alpha)
- ChEBML_153549 In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha)
- ChEBML_154544 In vitro binding affinity against human PPAR alpha (peroxisome proliferator-activated alpha receptor)
- ChEMBL_2302952 Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate
- ChEMBL_466427 (CHEMBL926870) Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat hippocampus
- ChEMBL_466428 (CHEMBL926871) Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat amygdala
- ChEMBL_466429 (CHEMBL926872) Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat cortex
- ChEMBL_529575 (CHEMBL970278) Activation of rat AMPK-alpha-1-alpha-2beta-1-gamma-1 kinase
- ChEMBL_1832261 (CHEMBL4332269) Inhibition of recombinant human N-terminal GST-fused IDH1 R132H mutant expressed in Escherichia coli using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrate addition
- ChEMBL_1832263 (CHEMBL4332271) Inhibition of recombinant human N-terminal GST-fused IDH1 R132C mutant expressed in Escherichia coli using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrate addition
- ChEMBL_1832264 (CHEMBL4332272) Inhibition of recombinant human N-terminal GST-fused IDH1 R132L mutant expressed in Escherichia coli using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrate addition
- ChEMBL_2165763 (CHEMBL5050624) Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 60 mins by Kinase-GLO reagent based assay
- ChEMBL_1794140 (CHEMBL4266257) Inhibition of L1196M mutant (unknown origin)
- ChEMBL_1822317 (CHEMBL4322081) Inhibition of HIV1 protease V82F mutant
- ChEMBL_1822318 (CHEMBL4322082) Inhibition of HIV1 protease G48V mutant
- ChEMBL_1822319 (CHEMBL4322083) Inhibition of HIV1 protease V82A mutant
- ChEMBL_1933800 (CHEMBL4479452) Inhibition of human EGFR T790M mutant
- ChEMBL_2050820 (CHEMBL4705519) Inhibition of human ALK C1156Y mutant
- ChEMBL_2050821 (CHEMBL4705520) Inhibition of human ALK L1196M mutant
- ChEMBL_2074230 (CHEMBL4729764) Inhibition of human FBPase S124A mutant
- ChEMBL_2074231 (CHEMBL4729765) Inhibition of human FBPase N125A mutant
- ChEMBL_2074232 (CHEMBL4729766) Inhibition of human FBPase D127A mutant
- ChEMBL_2074233 (CHEMBL4729767) Inhibition of human FBPase R243A mutant
- ChEMBL_2074235 (CHEMBL4729769) Inhibition of human FBPase Y258A mutant
- ChEMBL_2110584 (CHEMBL4819434) Inhibition of mouse COX2 S530A mutant
- ChEMBL_2110585 (CHEMBL4819435) Inhibition of mouse COX2 R120Q mutant
- ChEMBL_2264768 Inhibition of FLT3 D835Y mutant (unknown origin)
- ChEMBL_2265309 Inhibition of ALK L1196M mutant (unknown origin)
- ChEMBL_2270533 Inhibition of FLT3-ITD mutant (unknown origin)
- ChEMBL_2270534 Inhibition of FLT3 D835Y mutant (unknown origin)
- ChEMBL_2270536 Inhibition of FLT3 D835H mutant (unknown origin)
- ChEMBL_2270572 Inhibition of FLT3-D835Y mutant (unknown origin)
- ChEMBL_2271436 Inhibition of Abl T315I mutant (unknown origin)
- ChEMBL_2277133 Inhibition of HIV-1 integrase Q148K mutant
- ChEMBL_2278133 Inhibition of FGFR1 V561M mutant (unknown origin)
- ChEMBL_2278134 Inhibition of FGFR2 V564M mutant (unknown origin)
- ChEMBL_2278135 Inhibition of FGFR3 V555M mutant (unknown origin)
- ChEMBL_2278137 Inhibition of FGFR4 V550L mutant (unknown origin)
- ChEMBL_2278142 Inhibition of RET V804M mutant (unknown origin)
- ChEMBL_2278146 Inhibition of ALK L1196M mutant (unknown origin)
- ChEMBL_2278147 Inhibition of ALK G1202R mutant (unknown origin)
- ChEMBL_2281215 Inhibition of SHP2 (unknown origin) E76K mutant
- ChEMBL_2283198 Inhibition of EGFR L858R mutant (unknown origin)
- ChEMBL_2284321 Inhibition of ALK L1196M mutant (unknown origin)
- ChEMBL_2294502 Inhibition of EGFR L858R mutant (unknown origin)
- ChEMBL_2298700 Inhibition of IDH1 R132H mutant (unknown origin)
- ChEMBL_2299115 Inhibition of ALK G1202R mutant (unknown origin)
- ChEMBL_2321730 Inhibition of CFTR G551D mutant (unknown origin)
- ChEMBL_2321782 Inhibition of TTR V30M mutant (unknown origin)
- ChEMBL_2321783 Inhibition of TTR V122I mutant (unknown origin)
- ChEMBL_2331104 Inhibition of EGFR L858R mutant (unknown origin)
- ChEMBL_2331105 Inhibition of EGFR Del19 mutant (unknown origin)
- ChEMBL_2331106 Inhibition of EGFR LTb mutant (unknown origin)
- ChEMBL_2331107 Inhibition of EGFR dTCb mutant (unknown origin)
- ChEMBL_2331108 Inhibition of EGFR LTCb mutant (unknown origin)
- ChEMBL_2336380 Inhibition of JAK2 V617F mutant (unknown origin)
- ChEMBL_2342478 Inhibition of LRRK2 G2019S mutant (unknown origin)
- ChEMBL_2346395 Inhibition of FLT3 ITD mutant (unknown origin)
- ChEMBL_2346396 Inhibition of FLT3 D835Y mutant (unknown origin)
- ChEMBL_2348662 Inhibition of ALK L1196M mutant (unknown origin)
- ChEMBL_2348663 Inhibition of ALK G1269A mutant (unknown origin)
- ChEMBL_2348664 Inhibition of ALK G1202R mutant (unknown origin)
- ChEMBL_2353757 Inhibition of NSD2 E1099K mutant (unknown origin)
- ChEMBL_2353758 Inhibition of NSD2 T1150A mutant (unknown origin)
- ChEMBL_2356567 Inhibition of KIT D816V mutant (unknown origin)
- ChEMBL_2356568 Inhibition of PDGFRalpha D842V mutant (unknown origin)
- ChEMBL_2357239 Inhibition of IDH2 R140Q mutant (unknown origin)
- ChEMBL_2359390 Inhibition of EZH2 Y641F mutant (unknown origin)
- ChEMBL_2377742 Inhibition of PI3Kalpha H1047R mutant (unknown origin)
- ChEMBL_2379324 Inhibition of HIV-1 integrase Q148K mutant
- ChEMBL_2424714 Inhibition of BRAF V600E mutant (unknown origin)
- ChEMBL_2427237 Inhibition of FGFR4 C552A mutant (unknown origin)
- ChEMBL_2427238 Inhibition of FGFR4 C477A mutant (unknown origin)
- ChEMBL_2434882 Inhibition of KRAS G12C mutant (unknown origin)
- ChEMBL_2443858 Potentiation of CFTR F508del mutant (unknown origin)
- ChEMBL_2443866 Activation of CFTR F508del mutant (unknown origin)
- ChEMBL_2444527 Agonist activity against rat mGlu4 R60A mutant
- ChEMBL_2444528 Agonist activity against rat mGlu4 K74A mutant
- ChEMBL_2444529 Agonist activity against rat mGlu4 S160A mutant
- ChEMBL_2444530 Agonist activity against rat mGlu4 S160D mutant
- ChEMBL_2444531 Agonist activity at rat mGlu4 R258A mutant
- ChEMBL_2444535 Agonist activity at rat mGlu7 K60A mutant
- ChEMBL_2444537 Agonist activity at rat mGlu7 N74A mutant
- ChEMBL_2444538 Agonist activity at rat mGlu7 N74K mutant
- ChEMBL_2444539 Agonist activity at rat mGlu7 S160A mutant
- ChEMBL_2444540 Agonist activity at rat mGlu7 Q258A mutant
- ChEMBL_2451391 Inhibition of RET V804M mutant (unknown origin)
- ChEMBL_2451404 Inhibition of RET V804L mutant (unknown origin)
- ChEMBL_2451407 Inhibition of RET G810A mutant (unknown origin)
- ChEMBL_2451408 Inhibition of RET G810D mutant (unknown origin)
- ChEMBL_2451409 Inhibition of RET G810S mutant (unknown origin)
- ChEMBL_2451410 Inhibition of RET G810V mutant (unknown origin)
- ChEMBL_2451411 Inhibition of RET G810C mutant (unknown origin)
- ChEMBL_2451412 Inhibition of RET G810R mutant (unknown origin)
- ChEMBL_2470558 Inhibition of BRAF V600E mutant (unknown origin)
- ChEMBL_2476258 Inhibition of BRAF V600E mutant (unknown origin)
- ChEMBL_2476282 Inhibition of EGFR L858R mutant (unknown origin)
- ChEMBL_2476909 Inhibition of FGFR2 V564F mutant (unknown origin)
- ChEMBL_2481991 Inhibition of TRKA G595R mutant (unknown origin)
- ChEMBL_2481992 Inhibition of TRKA G667C mutant (unknown origin)
- ChEMBL_2481998 Inhibition of TRKC G623R mutant (unknown origin)
- ChEMBL_2481999 Inhibition of ALK G1202R mutant (unknown origin)
- ChEMBL_2482001 Inhibition of RET G810R mutant (unknown origin)
- ChEMBL_2482003 Inhibition of FLT3 ITD mutant (unknown origin)
- ChEMBL_2482004 Inhibition of FLT3 D835Y mutant (unknown origin)
- ChEMBL_2484874 Inhibition of IDH1 R132H mutant (unknown origin)
- ChEMBL_2484875 Inhibition of IDH1 R132C mutant (unknown origin)
- ChEMBL_2488975 Inhibition of FLT3 ITD mutant (unknown origin)
- ChEMBL_2488979 Inhibition of FLT3 D835Y mutant (unknown origin)
- ChEMBL_2489716 Inhibition of EGFR L858R mutant (unknown origin)
- ChEMBL_2489717 Inhibition of EGFR T790M mutant (unknown origin)
- ChEMBL_2491809 Inhibition of FLT3 D835H mutant (unknown origin)
- ChEMBL_2492004 Inhibition of ALK L1196M mutant (unknown origin)
- ChEMBL_2495358 Inhibition of FLT3-ITD mutant (unknown origin)
- ChEMBL_2495629 Inhibition of IDH1 R132H mutant (unknown origin)
- ChEMBL_2495630 Inhibition of IDH1 R132C mutant (unknown origin)
- ChEMBL_2495631 Inhibition of IDH2 R140Q mutant (unknown origin)
- ChEMBL_2495632 Inhibition of IDH2 R172K mutant (unknown origin)
- ChEMBL_2497249 Inhibition of EGFR T790M mutant (unknown origin)
- ChEMBL_2504395 Inhibition of EZH2 Y641F mutant (unknown origin)
- ChEMBL_2511011 Inhibition of Abl T315I mutant (unknown origin)
- ChEMBL_2516364 Inhibition of RET V804L mutant (unknown origin)
- ChEMBL_2516365 Inhibition of RET Y791F mutant (unknown origin)
- ChEMBL_391664 (CHEMBL871553) Inhibition of human ACE Y1096F mutant
- ChEMBL_391665 (CHEMBL871554) Inhibition of human ACE K1087A mutant
- ChEMBL_399772 (CHEMBL910307) Inhibition of HIV1 protease I8 mutant
- ChEMBL_445721 (CHEMBL896012) Inhibition of HIV1 protease D30N mutant
- ChEMBL_445722 (CHEMBL896013) Inhibition of HIV1 protease I50V mutant
- ChEMBL_445723 (CHEMBL896014) Inhibition of HIV1 protease V82A mutant
- ChEMBL_445724 (CHEMBL896015) Inhibition of HIV1 protease I84V mutant
- ChEMBL_491409 (CHEMBL945372) Inhibition of HTLV1 protease L40I mutant
- ChEMBL_646978 (CHEMBL1217119) Inhibition of B-Raf V600E mutant
- ChEMBL_766930 (CHEMBL1828155) Binding affinity to BRAF V600E mutant