Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PHD1 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of PHD2 (181 to 417) (unknown origin) using HIF-1alpha peptide as substrate assessed as 2-Oxoglutarate conversion to succinic acid by beta...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant EGLN-1 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of full length human recombinant EGLN-3 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate preincubated for 1 hr followed by substrate addition measured after 1 hr by [14...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of PHD2 (181 to 417) (unknown origin) using HIF-1alpha peptide as substrate assessed as 2-Oxoglutarate conversion to succinic acid preincu...More data for this Ligand-Target Pair
Affinity DataIC50: <50nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate preincubated for 1 hr followed by substrate addition measured after 1 hr by [14...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human PHD2 expressed in Sf9 cells using HIF-1alpha peptide as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Inhibition of PHD2 (unknown origin) using P564 HIFlalpha as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of 6xHis-tagged VHL (unknown origin) expressed in Escherichia coli BL21 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant EGLN-1 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of full length human recombinant EGLN-3 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human recombinant EGLN-1 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISAMore data for this Ligand-Target Pair