Compile Data Set for Download or QSAR
maximum 50k data
Found 41 Enz. Inhib. hit(s) with all data for entry = 50041816
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM86716(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)
Affinity DataKi:  6.76nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  36.3nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416269(CHEMBL1082329)
Affinity DataKi:  49.0nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416264(CHEMBL1082987)
Affinity DataKi:  57.5nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416276(CHEMBL1082975)
Affinity DataKi:  72.4nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416263(CHEMBL1086591)
Affinity DataKi:  77.6nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416265(CHEMBL1083340)
Affinity DataKi:  83.2nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416270(CHEMBL1082976)
Affinity DataKi:  87.1nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416260(CHEMBL1083598)
Affinity DataKi:  89.1nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416271(CHEMBL1084474)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416272(CHEMBL1084475)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416275(CHEMBL1083341)
Affinity DataKi:  123nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416279(CHEMBL1084476)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342430((R)-cyclobutyl(2-(3-m-tolyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416273(CHEMBL1084477)
Affinity DataKi:  138nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416266(CHEMBL1082722)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342460((S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416277(CHEMBL1082635)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416268(CHEMBL1082637)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416267(CHEMBL1082636)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416278(CHEMBL1082328)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataKi:  204nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416274(CHEMBL1082666)
Affinity DataKi:  229nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416261(CHEMBL1082667)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416262(CHEMBL1082668)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416263(CHEMBL1086591)
Affinity DataKi:  741nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416269(CHEMBL1082329)
Affinity DataIC50:  214nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416276(CHEMBL1082975)
Affinity DataIC50:  224nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416260(CHEMBL1083598)
Affinity DataIC50:  251nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416270(CHEMBL1082976)
Affinity DataIC50:  295nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416263(CHEMBL1086591)
Affinity DataIC50:  339nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342430((R)-cyclobutyl(2-(3-m-tolyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataIC50:  490nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342460((S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Affinity DataIC50:  501nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416265(CHEMBL1083340)
Affinity DataIC50:  759nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416266(CHEMBL1082722)
Affinity DataIC50:  1.00E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416267(CHEMBL1082636)
Affinity DataIC50:  1.05E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataIC50:  1.17E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416278(CHEMBL1082328)
Affinity DataIC50:  1.74E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416275(CHEMBL1083341)
Affinity DataIC50:  6.61E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416277(CHEMBL1082635)
Affinity DataIC50:  3.02E+4nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50416268(CHEMBL1082637)
Affinity DataIC50:  3.02E+4nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed