Compile Data Set for Download or QSAR
Report error Found 1125 for UniProtKB: P34975
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.00300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataIC50: 0.00400nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00400nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00900nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50: 0.0150nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50: 0.0200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM94503(N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piper...)
Affinity DataKi:  0.0200nMAssay Description:In vitro affinity to displace [3H]naloxone from opiate receptor in freshly prepared rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2019
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0270nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0290nMAssay Description:Dissociation constant against wild type EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0380nMAssay Description:Dissociation constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0500nMAssay Description:Dissociation constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKd:  0.0500nMAssay Description:Dissociation constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0500nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50346950(CHEMBL485832)
Affinity DataKi:  0.0600nMAssay Description:Mutant factor of the compound against mu-[K303E] with Opioid receptor kappa 1 for binding affinityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NORBNI | NOR-BNI (HCI)2)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.0800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50: 0.0850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50346950(CHEMBL485832)
Affinity DataKi:  0.0900nMAssay Description:Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM81931(N-cyclopropylmethylnorazidomorphine | CAS_56337-94...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50001119(CHEMBL101535 | 8-(4-Oxo-1-phenyl-1,3,8-triaza-spir...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the binding affinity towards opioid receptor from rat whole brain using [3H]etorpine (33.2 Ci/mmol,0.2nanoM)as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50290967(CI-977 | 2-Benzofuran-4-yl-N-methyl-N-((5R,7S,8S)-...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]U-69593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50133053(Opioid Peptide [d-Ala(8)]Dynorphin derivative | CH...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity towards rat Opioid receptor kappa 1 expressed in CHO cells of chinese hamster ovary was determined using [3H]diprenorphine as radiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM85780([(R)-Atc4, D-Ala8]Dyn A-(1-11)NH2 | [(S)-Atc4 , D-...)
Affinity DataKi:  0.114nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NORBNI | NOR-BNI (HCI)2)
Affinity DataKi:  0.120nMAssay Description:Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50133226(15-methoxy-3-methyl-19-(1-methylbutyl)-13-oxa-3-az...)
Affinity DataKi:  0.130nMAssay Description:Binding affinity against Opioid receptor kappa 1 isolated from rat brain membrane was determined using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50010704(Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Ly...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50138775(cyclo[D-Asp2,Dap5]Dyn A-(1-13)NH2 | CHEMBL428669)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50367123(M99 | ETORPHINE)
Affinity DataKi:  0.180nMAssay Description:Binding affinity against Opioid receptor kappa 1 isolated from rat brain membrane was determined using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50225213(CHEMBL606820)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50326670(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50138768(Linear [D-Asp2,Dap5]Dyn A-(1-13)NH2 | CHEMBL438781)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50225206(CHEMBL606643)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM81931(N-cyclopropylmethylnorazidomorphine | CAS_56337-94...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50138766(cyclo[D-Ala3]Dyn A-(1-11)NH2 | CHEMBL439272)
Affinity DataKi:  0.210nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50090099(5'-Amidinomethyl-17-cyclopropylmethyl-6,7-didehydr...)
Affinity DataKi:  0.214nMAssay Description:Binding affinity on HEK293 cells transiently transfected with plasmids encoding the rat Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50090102(5'-N-Biguanidino-17-cyclopropylmethyl-6,7-didehydr...)
Affinity DataKi:  0.226nMAssay Description:Binding affinity on HEK293 cells transiently transfected with plasmids encoding the rat Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NORBNI | NOR-BNI (HCI)2)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]diprenorphine from delta-W284E-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50090100(Norbinaltorphimine (norBNI) | CHEMBL319202)
Affinity DataKi:  0.244nMAssay Description:Binding affinity on HEK293 cells transiently transfected with plasmids encoding the rat Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50012477(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [3H]nalotrexone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50036266(Dyn A(H-Tyr-Gly-Ala-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Ly...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  0.270nMAssay Description:Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50068379(5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6...)
Affinity DataKi:  0.290nMAssay Description:Mutant factor against mu-[K303E] with Opioid receptor kappa 1 for binding affinityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225848(CHEMBL53563)
Affinity DataIC50: 0.300nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50013184(CHEMBL343066 | 1H-Indole-2-carboxylic acid [5-(2-f...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM81931(N-cyclopropylmethylnorazidomorphine | CAS_56337-94...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50225214(CHEMBL606769)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
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