Compile Data Set for Download or QSAR
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Found 104 of affinity data for UniProtKB/TrEMBL: P00403
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587911(CHEMBL5183049)
Affinity DataKi:  9.46E+4nMAssay Description:Binding affinity to human recombinant COX-2 assessed as inhibition constant preincubated for 5 mins followed by arachidonic acid addition measured ev...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant COX-2 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50229774(CHEMBL254418 | N-Hydroxy-4-(5-methyl-3-phenylisoxa...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598758(CHEMBL5199117)
Affinity DataIC50:  190nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598765(CHEMBL5207189)
Affinity DataIC50:  240nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  293nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of COX-2 in LPS-stimulated human whole blood assessed as reduction in PGE2 production by immunoassayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50515743(CHEMBL4448990)
Affinity DataIC50:  367nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598750(CHEMBL5193981)
Affinity DataIC50:  490nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50515744(CHEMBL4441570)
Affinity DataIC50:  513nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  540nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598754(CHEMBL5173923)
Affinity DataIC50:  550nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598757(CHEMBL5191029)
Affinity DataIC50:  560nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  610nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50515745(CHEMBL4474644)
Affinity DataIC50:  915nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598766(CHEMBL5170447)
Affinity DataIC50:  930nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50558934(CHEMBL4754218)
Affinity DataIC50:  980nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM13063(4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sul...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM35905(Tolfenamic acid | cid_610479 | flufenamic acid ana...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50589148(CHEMBL5187847)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM35905(Tolfenamic acid | cid_610479 | flufenamic acid ana...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592551(CHEMBL5206236)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598747(CHEMBL5207774)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50558936(CHEMBL4794507)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592554(CHEMBL5189018)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598752(CHEMBL5178874)
Affinity DataIC50:  3.01E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592555(CHEMBL5171524)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592557(CHEMBL5183520)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50558937(CHEMBL4779865)
Affinity DataIC50:  4.23E+3nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592556(CHEMBL5199286)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598751(CHEMBL5184694)
Affinity DataIC50:  4.95E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598756(CHEMBL5208621)
Affinity DataIC50:  5.52E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598753(CHEMBL5191175)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50558935(CHEMBL4742170)
Affinity DataIC50:  6.29E+3nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592563(CHEMBL5199367)
Affinity DataIC50:  6.38E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50598755(CHEMBL5186581)
Affinity DataIC50:  6.79E+3nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592558(CHEMBL5188131)
Affinity DataIC50:  7.37E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50592559(CHEMBL5191274)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595002(CHEMBL5202541)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595006(CHEMBL5169638)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595000(CHEMBL5182136)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595001(CHEMBL5176910)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595007(CHEMBL5200035)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595003(CHEMBL5196941)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 2(Homo sapiens (Human))
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50595004(CHEMBL5197349)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of cox-2 (unknown origin) incubated for 5 mins by 96-well plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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