Compile Data Set for Download or QSAR
Report error Found 36 of affinity data for UniProtKB/TrEMBL: Q8TCT8
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597200BDBM50597200(CHEMBL5204104)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597198BDBM50597198(CHEMBL5203663)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597201BDBM50597201(CHEMBL5182068)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597199BDBM50597199(CHEMBL5171841)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597203BDBM50597203(CHEMBL5199989)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597202BDBM50597202(CHEMBL5197736)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SPPL2A expressed in human U2OS cells assessed as nuclear mask transferring to EGFP channel using EGFP-labeled TNFalpha (aa1-76) N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546132BDBM50546132(CHEMBL4759048)
Affinity DataIC50: 4nMAssay Description:Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262993BDBM50262993(CHEMBL4059711)
Affinity DataIC50: 5nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263008BDBM50263008(CHEMBL255473)
Affinity DataIC50: 6nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546130BDBM50546130(CHEMBL4762492)
Affinity DataIC50: 7nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546132BDBM50546132(CHEMBL4759048)
Affinity DataIC50: 9nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546128BDBM50546128(CHEMBL4753654)
Affinity DataIC50: 13nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546125BDBM50546125(CHEMBL4792187)
Affinity DataIC50: 15nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546131BDBM50546131(CHEMBL4759943)
Affinity DataIC50: 25nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262979BDBM50262979(CHEMBL4077007)
Affinity DataIC50: 35nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263007BDBM50263007(CHEMBL4076827)
Affinity DataIC50: 44nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262968BDBM50262968(CHEMBL4064631)
Affinity DataIC50: 70nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263010BDBM50263010(CHEMBL4100749)
Affinity DataIC50: 76nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546124BDBM50546124(CHEMBL4740837)
Affinity DataIC50: 88nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546118BDBM50546118(CHEMBL4762370)
Affinity DataIC50: 200nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263005BDBM50263005(CHEMBL4077336)
Affinity DataIC50: 225nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546122BDBM50546122(CHEMBL4747630)
Affinity DataIC50: 350nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546123BDBM50546123(CHEMBL4789381)
Affinity DataIC50: 620nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546129BDBM50546129(CHEMBL4785324)
Affinity DataIC50: 840nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546120BDBM50546120(CHEMBL4743609)
Affinity DataIC50: 860nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263006BDBM50263006(CHEMBL4074838)
Affinity DataIC50: 870nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546127BDBM50546127(CHEMBL4753079)
Affinity DataIC50: 900nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546121BDBM50546121(CHEMBL4798232)
Affinity DataIC50: 910nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262965BDBM50262965(CHEMBL4105093)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262967BDBM50262967(CHEMBL4075787)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546126BDBM50546126(CHEMBL4741014)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262966BDBM50262966(CHEMBL4086098)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546119BDBM50546119(CHEMBL4762488)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed