131 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Pharmaceutical Companies of Johnson & Johnson
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
E.I. Du Pont De Nemours
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Siena
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Eastern Finland
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Eastern Finland
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Szeged
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Roseman University of Health Sciences
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Pharmaceutical Companies of Johnson & Johnson
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Lille
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research and Development
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Eastern Finland
Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Mcphs University
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of M£Nster
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
An unprecedented reversible mode of action ofß-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universite Catholique De Louvain
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research and Development
Synopsis of some recent tactical application of bioisosteres in drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research and Development
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sapienza University of Rome
Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
SAR and LC/MS studies ofß-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research and Development
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute For Chemical Biology
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research & Development
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research and Development
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vernalis (R&D)
Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Max Planck Institute of Molecular Physiology
Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Lille
Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Renovis
Oxime carbamate--discovery of a series of novel FAAH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research & Development
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Louvain Drug Research Institute
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universite Catholique De Louvain
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vernalis (R&D)
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research and Development
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Liberty University
Synthesis and evaluation of dual fatty acid amide hydrolase-monoacylglycerol lipase inhibition and antinociceptive activities of 4-methylsulfonylaniline-derived semicarbazones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Indian Institute of Technology (Banaras Hindu University)
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Central University of Punjab
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bari Aldo Moro
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Scripps Research Institute
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
California State University
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Pharmaceutical Companies of Johnson & Johnson
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Utrecht University
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Assam University (A Central University)
Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research & Development
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research & Development
Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
China Pharmaceutical University
Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
China Pharmaceutical University
Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northeastern University
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ehime University
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Palack£
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Advinus Therapeutics
Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northeastern University
An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute For Chemical Biology
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Julius Maximilian University of W£Rzburg
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California Davis
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bern
Biological evaluation of pyridone alkaloids on the endocannabinoid system.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Bern
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Ferrara
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis, biological evaluation, and molecular docking studies of new pyrazol-3-one derivatives with aromatase inhibition activities.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Yueyang Vocational Technical College
Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Synaptic Pharmaceutical
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Synaptic Pharmaceutical
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Kalypsys
Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Wyeth Research
Stereospecific synthesis, structure-activity relationship, and oral bioavailability of tetrahydropyrimidin-2-one HIV protease inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Dupont Pharmaceuticals