51 articles for thisTarget
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Article Title
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Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.
Leiden University
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?
Merck Research Laboratories
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
Merck Research Laboratories
Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.
Universit£
Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation.
Parke-Davis Pharmaceutical Research
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
University of Pittsburgh
Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.
University College London
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.
Merck Research Laboratories
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.
Wayne State University
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Yale University
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli
TBA
Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.
Pharmacopeia
Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.
Janssen Research Foundation
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
Abbott Laboratories
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Merck Research Laboratories
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.
Università
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Abbott Laboratories
Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.
Abbott Laboratories
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.
Imperial College
Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.
Gpc Biotech
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Abbott Laboratories
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Johnson & Johnson Pharmaceutical Research & Development
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Abbott Laboratories
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.
Abbott Laboratories
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Merck Research Laboratories
Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Merck Research Laboratories
A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.
Banyu Tsukuba Research Institute
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Yale University
A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).
Lgci
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
Merck Research Laboratories
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
Merck Research Laboratories
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Merck Research Laboratories
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.
Merck Research Laboratories
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
Bristol-Myers Squibb Pharmaceutical Research Institute
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Merck Research Laboratories
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Merck Research Laboratories
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Yale University
Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.
Schering-Plough Research Institute
Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.
Schering-Plough Research Institute
Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.
Università
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Bristol-Myers Squibb Pharmaceutical Research Institute
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
University of Minnesota
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
Temple University
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
Janssen Research Foundation
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.
Duke University Medical Center