156 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Suven Life Sciences
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kansas
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Alexander Shulgin Research Institute
Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
C4 phenyl aporphines with selective h5-HT(2B) receptor affinity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Humanß3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Asahi Kasei Pharma
Cell-based and virtual fragment screening for adrenergica2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Teva Global R & D.
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Collegium Medicum
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northwestern University
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Missouri
Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Adamed
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Favourable involvement ofa2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Camerino
Might the observeda(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
A QSAR study using MTD method and Dragon descriptors for a series of selective ligands ofa2C adrenoceptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Timisoara of The Romanian Academy
Fruitful adrenergica(2C)-agonism/a(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universita` Di Camerino
Rigid analogues of thea2-adrenergic blocker atipamezole: small changes, big consequences.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pierre Fabre Research Center
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universita Degli Studi Di Camerino
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Discovery and SAR of org 24598-a selective glycine uptake inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Organon Research and Development Group
New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research Foundation
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Savannah State University
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Sydney
Methylation of imidazoline related compounds leads to loss ofa2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Strasburg
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Sydney
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Westfalische Wilhelms-Universitat
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hunter College and The Graduate Center of The City University of New York
Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective alpha(2C)-adrenergic receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyowa Hakko Kogyo
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alcon Research
Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Allergan
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Synaptic Pharmaceutical
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Design and synthesis of novel dihydropyridine alpha-1a antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Synaptic Pharmaceutical
Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Sydney
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Spiroindolones, a potent compound class for the treatment of malaria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Swiss Tropical and Public Health Institute
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University
Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Sydney
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dipartimento Di Scienze Farmaceutiche
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pharmaceutical Research Institute
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Università
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Juvantia Pharma
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kansas
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University College of Physicians and Surgeons
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alcon Research
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University College of Physicians and Surgeons
Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chungbuk National University
Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Tennessee
Distal kinetic deuterium isotope effect: Phenyl ring deuteration attenuates N-demethylation of Lu AF35700.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
H. Lundbeck
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Emory University
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Novel Substituted Heterocyclic Carboxamides as Adrenoreceptor ADRAC2 Inhibitors for Treating Diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smith, Gambrell & Russell
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Binding of beta-carbolines at 5-HT(2) serotonin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research & Development
Structure-Activity Relationship of Heterocyclic P2Y![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universita Di Camerino
Discovery of potent and selective small molecule NPY Y5 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Lundbeck Research Usa
Exploration of Alternative Scaffolds for P2Y![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Mississippi
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Synaptic Pharmaceutical
Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The R. W. Johnson Pharmaceutical Research Institute
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Neurological Disorders and Stroke
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Synaptic Pharmaceutical
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign pr![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Allergan
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Minnesota Twin Cities
Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a potent, peripherally acting alpha 2 adrenoceptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Allergan
Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Pharmaceutica
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northwestern University
Fluorinated analogues of marsanidine, a highly ?2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medical University of Gdansk
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Camerino
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Discovery Laboratory
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Qbi Covid-19 Research Group (Qcrg)
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline Research Laboratories
2-amino-2-oxazolines as subtype selective alpha(2) adrenoceptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Lundbeck Research Usa
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
New York University Medical Center
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Texas Tech University Health Sciences Center
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Texas At Austin
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Yogi Vemana University
Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Institut De Recherches Servier