BDBM8960 (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one::2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one::Aricept::Aricept odt::CHEMBL1678::CHEMBL2337271::CHEMBL502::DONEPEZIL HYDROCHLORIDE::Donepezil::Donepzil::E2020::US8999994, Donepezil::US9346818, DPH::US9586925, Donepezil::US9663465, Donepezil
SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
InChI Key InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 375 hits for monomerid = 8960
Affinity DataKi: 2.90nM ΔG°: -11.6kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 2.90nMAssay Description:Inhibition of fetal Bovine serum AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Inhibition of electric eel AChE pre-incubated for 3 mins before acetylthiocholine substrate addition by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 7.20nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Mixed inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Mixed type inhibition of human AChE using acetylthiocholineiodide as substrate measured for every 30 sec for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of electric eel AChE assessed as inhibition constant using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataKi: 20.5nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
Affinity DataKi: 20.5nM ΔG°: -10.9kcal/mole IC50: 23.1nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition assay using AChE and BuChE.More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Mixed-type inhibition of human AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition by Lineweaver-B...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataKi: 56nMAssay Description:Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMpH: 8.0 T: 2°CAssay Description:Suitable agents like donepezil hydrochloride and tacrine hydrochloride hydrate were used as standards for this study. Buffer solution (50 mM Tris-HCl...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 6.70nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 19nMpH: 8.0Assay Description:Inhibitory activities of AChE and BChE were evaluated by using the Ellman's method [34]. Herein compounds 2(a-h) and 5(a-h) were evaluated as inh...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Newly synthesized coumarin thioureas were tested against electric eel AChE and horse serum BChE. The cholinesterase inhibitory activity was measured ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 60nMpH: 8.0Assay Description:AChE inhibitory activity was measured with a Molecular Devices Spectra Max Plus 384 spectrophotometer (CA, USA) based on Ellman's method with sli...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The in vitro AChE inhibitory activity was measured using the methods described earlier [Biochem. Pharmacol. 7:88-95]. Briefly, stock solutions (1mg/m...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMpH: 8.0Assay Description:The synthesized compounds (each separately) were dissolved in a mixture of DMSO (1 ml) and methanol (9 ml) and then diluted in KH2PO4/K2HPO4 buffer (...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 59nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of
5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a
colored product. Sh...More data for this Ligand-Target Pair
Affinity DataIC50: 6.16nMpH: 8.0 T: 2°CAssay Description:Reactions were performed in a mediumcontaining substrate (0.05-0.4 mM) combined with 0.125 mM DTNB in 100 mM 3-(N-morpholino)propanesulfonic acid buf...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:The stock solutions of the target compounds were prepared in a mixture of DMSO (1 ml) and ethanol (9 ml) and diluted with 0.1 MKH2PO4/K2HPO4 buffer (...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:For AChE or BuChE inhibition assays, a reaction mixture (100 mL) containing acetylthiocholine iodide (1 mmol/L, 30 mL) or butyrylthiocholine iodide (...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description:AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 20nMpH: 8.0 T: 2°CAssay Description:Seven different concentrations of the synthesized compounds in the range 10^−3-10^−9 M were measured at 412 nm. All the assays were under...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 54nMpH: 8.0 T: 2°CAssay Description:Enzyme solutions were prepared in gelatine solution (1%), at a concentration of 2.5 units/mL. AChE or BChE solution (50 μL) and compound solutio...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californicaMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eelMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of human recombinant AChE.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:In vitro inhibitory effect on rat AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge measure...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Tehran University Of Medicinal Sciences
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of AChE (unknown origin) after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in human erythrocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity of the compound was tested against Acetylcholinesterase (AChE) in rat brain hippocamal crude homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration required against acetylcholinesterase activityMore data for this Ligand-Target Pair