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TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517230(CHEMBL4467984)
Affinity DataKi:  0.840nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517232(CHEMBL4546839)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50251208(CHEMBL4088272)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517229(CHEMBL4541515)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  2.20nMAssay Description:Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517236(CHEMBL4465127)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-spiperone from DRD2 in rat striatum by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membranes by scintillation countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064946(4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-hydro...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064946(4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-hydro...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50036734((S)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Beijing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50387918(CHEMBL2058680 | US9283222, 459)
Affinity DataKi:  3nMAssay Description:Binding affinity to PARP-1 (unknown origin) assessed as inhibition constant incubated for 1 hr by topcount microplate scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517222(CHEMBL4579585)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082611(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  5.70nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082575(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from DRD3 in rat olfactory tubercle by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082578(6-Chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline...)
Affinity DataKi:  6.60nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517233(CHEMBL4568756)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  10nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517221(CHEMBL4554135)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082589(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  11nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082579(6-Chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50550237(CHEMBL4747257)
Affinity DataKi:  13nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50550237(CHEMBL4747257)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membranes by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517223(CHEMBL4471116)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50010289((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H] spiperone from human D2 dopamine receptor expressed in monkey caudate-putamen membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082583(Acetic acid 2-{1-[5-guanidino-2-(3-methyl-1,2,3,4-...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50580184(CHEMBL5079556)
Affinity DataKi:  16nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082589(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  20nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  20nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082577(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082598(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082612(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  28nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082580(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  32nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082608(CHEMBL139718 | Succinic acid mono-(2-{1-[5-guanidi...)
Affinity DataKi:  34nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50151392(CHEMBL3775262)
Affinity DataKi:  43nMAssay Description:Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082581(CHEMBL143203 | N-(2-{1-[2-(3,3-Dimethyl-1,2,3,4-te...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082573(3-Methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic a...)
Affinity DataKi:  44nMAssay Description:The compound was evaluated for the inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517226(CHEMBL4449666)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bovine)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50082591(CHEMBL139606 | N-(2-{1-[5-Guanidino-2-(3-methyl-1,...)
Affinity DataKi:  45nMAssay Description:Inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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