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TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123058(2-(3,5-dichloro-4-(4-hydroxy-3-(piperidin-1-ylsulf...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123046(2-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Affinity DataKi:  0.0300nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123045(CHEMBL413699 | N-Cyclohexyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123054(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604026(CHEMBL5192384)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123064(2-(3-chloro-4-(4-hydroxy-3-(piperidin-1-ylsulfonyl...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188475((R)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29100(dibenzothiazepine, 12h)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29098(dibenzothiazepine, 12e)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123063(2-{3,5-Dichloro-4-[4-hydroxy-3-(indole-1-sulfonyl)...)
Affinity DataKi:  0.230nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119386(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataKi:  0.280nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123061(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29096(dibenzothiazepine, 12b)
Affinity DataKi:  0.320nM ΔG°:  -53.6kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167934(CHEMBL191962 | N-{4-[4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123057(CHEMBL124039 | N-Cyclobutyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188476(CHEMBL209876 | N-4-[4-(3-chloro-2-methoxyphenyl)pi...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123056(2-(4-(4-hydroxy-3-(piperidin-1-ylsulfonyl)phenoxy)...)
Affinity DataKi:  0.460nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123062(CHEMBL340158 | N-Cyclohexyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.460nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167931(CHEMBL364516 | N-{4-[4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards porcine serotonin receptor 5-HT1A using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119390(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dic...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167931(CHEMBL364516 | N-{4-[4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.520nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119383(Benzo[b]tellurophene-2-carboxylic acid {4-[4-(2,3-...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.590nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167933(CHEMBL370297 | N-{4-[4-(2,3-dichlorophenyl)piperaz...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123049(2-(3,5-dichloro-4-(4-hydroxy-3-(piperidine-1-carbo...)
Affinity DataKi:  0.630nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167937(CHEMBL194555 | N-{4-[4-(2,3-dichlorophenyl)piperaz...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123050(CHEMBL124318 | N-Cyclobutyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119392(CHEMBL141845 | N-(2-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity for human Dopamine receptor D4 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119376(Benzo[b]tellurophene-2-carboxylic acid {4-[4-(2-me...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123055(2-(3,5-dichloro-4-(4-hydroxy-3-(morpholine-4-carbo...)
Affinity DataKi:  0.720nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29097(dibenzothiazepine, 12c)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167933(CHEMBL370297 | N-{4-[4-(2,3-dichlorophenyl)piperaz...)
Affinity DataKi:  0.840nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D3 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167935(CHEMBL195083 | N-{4-[4-(3-chloro-2-methoxyphenyl)p...)
Affinity DataKi:  0.910nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119377(Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phen...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29101(dibenzothiazepine, 12j)
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL25236 | CHEMBL540612 | N-(4-(4-(2-methoxyphe...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL25236 | CHEMBL540612 | N-(4-(4-(2-methoxyphe...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D3 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL25236 | CHEMBL540612 | N-(4-(4-(2-methoxyphe...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50119384(Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-p...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandPNGBDBM29102(dibenzothiazepine, 12k)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 22°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188474(CHEMBL426863 | N-[4-[4-(2,3-difluorophenyl)piperaz...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123060(2-{3-Chloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167930(2-{1-ferra-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]spiperone binding to human dopamine receptor D3 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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