Compile Data Set for Download or QSAR
maximum 50k data
Found 226 with Last Name = 'gathiaka' and Initial = 's'
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650996((5aSa,17aRa)-20-chloro-2- [(2S,5R)-2,5-dimethyl-4-...)
Affinity DataIC50:  0.510nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572114(CHEMBL4852458 | US20240043448, Example 74)
Affinity DataIC50:  0.510nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651033(US20240043448, Example 97)
Affinity DataIC50:  0.560nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651028(2'-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazi...)
Affinity DataIC50:  0.710nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650997(2-[(2S,5R)-2,5-dimethyl-4-(prop- 2-enoyl)piperazin...)
Affinity DataIC50:  0.740nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572113(CHEMBL4879271 | US20240043448, Example 59)
Affinity DataIC50:  0.910nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650991(US20240043448, Example 51-1)
Affinity DataIC50:  1nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650995((5aRa,18aRa)-2-[(2S,5R)-2,5- dimethyl-4-(prop-2- e...)
Affinity DataIC50:  1.10nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651024(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  1.10nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650990(US20240043448, Example 50)
Affinity DataIC50:  1.10nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572117(CHEMBL4863593 | US20240043448, Example 91)
Affinity DataIC50:  1.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650999(2'-[(2S,5R)-2,5-dimethyl-4-(prop- 2-enoyl)piperazi...)
Affinity DataIC50:  1.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579614(CHEMBL4871970)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572115(CHEMBL4864188 | US20240043448, Example 75)
Affinity DataIC50:  1.70nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650992(US20240043448, Example 52)
Affinity DataIC50:  1.80nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651008(US20240043448, Example 70)
Affinity DataIC50:  1.80nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577469(CHEMBL4850213)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579610(CHEMBL4873520)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572116(CHEMBL4855378 | US20240043448, Example 76)
Affinity DataIC50:  2.30nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651045(US20240043448, Example 109)
Affinity DataIC50:  2.30nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651000(2'-[(2S,5R)-2,5-dimethyl-4-(prop- 2-enoyl)piperazi...)
Affinity DataIC50:  2.30nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651013(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  2.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650993(US20240043448, Example 54)
Affinity DataIC50:  2.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572108(CHEMBL4869082 | US20240043448, Example 4a)
Affinity DataIC50:  2.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651014(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  2.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651031(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  2.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651016(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  2.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651015(15,18,21-trifluoro-2-[(2S)-2-methyl-4-(prop-2- eno...)
Affinity DataIC50:  2.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572119(CHEMBL4876119 | US20240043448, Example 119)
Affinity DataIC50:  2.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651004(12,12,17,18,21-pentafluoro-6- (propan-2-yl)-2-[4-(...)
Affinity DataIC50:  2.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650994((5aRa,18aRa)-2-[(2S,5R)-2,5- dimethyl-4-(prop-2- e...)
Affinity DataIC50:  2.70nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651017(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  2.90nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579616(CHEMBL4845730)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651030(US20240043448, Example 94)
Affinity DataIC50:  3.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572109(CHEMBL4870399 | US20240043448, Example 8)
Affinity DataIC50:  3.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651001(2'-[(2S,5R)-2,5-dimethyl-4-(prop- 2-enoyl)piperazi...)
Affinity DataIC50:  3.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651002(20-chloro-2-[(2S,5R)-2,5- dimethyl-4-(prop-2- enoy...)
Affinity DataIC50:  3.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651032(2-[(2S,5R)-2,5-dimethyl-4-(prop-2- enoyl)piperazin...)
Affinity DataIC50:  3.80nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579611(CHEMBL4871097)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM650976(17,20-difluoro-2-[(2S)-2- methyl-4-(prop-2- enoyl)...)
Affinity DataIC50:  3.90nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50538536(CHEMBL4639893)
Affinity DataIC50:  4nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50572110(CHEMBL4866126 | US20240043448, Example 10b)
Affinity DataIC50:  4.30nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651057(US20240043448, Example 120)
Affinity DataIC50:  4.30nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651007(2-[(2S,5R)-2,5-dimethyl-4-(prop- 2-enoyl)piperazin...)
Affinity DataIC50:  4.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651046(US20240043448, Example 110)
Affinity DataIC50:  4.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577476(CHEMBL4852406)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50579615(CHEMBL4865209)
Affinity DataIC50:  5nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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