TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.671nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.726nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.733nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 17.9nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranesMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as effect on amyloid beta42 level by meso scale discove...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 33.1nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 33.1nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 60 mins by FLIPR assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
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